Výsledky vyhledávání - "Melanie, Ruf"

Supplementary Figure S2 from pVHL/HIF-Regulated CD70 Expression Is Associated with Infiltration of CD27+ Lymphocytes and Increased Serum Levels of Soluble CD27 in Clear Cell Renal Cell Carcinoma

Autor: Peter Schraml, Holger Moch, Tullio Sulser, Maries van den Broek, Cédric Poyet, Thomas Hermanns, Arndt Hartmann, Anna M. Nowicka, Christiane Mittmann, Melanie Ruf

A) Western blot of HIF1α, HIF2α and CD70 in SLR22 after silencing of HIF1α, HIF2α or both together for 48 h and 72 h. B) Western blot of HIF2α and CD70 in SLR24 and C) SLR22 after transient overexpression of HIF2α and D) in A498 and E) SLR22 af

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e2b84f0c42b77f986668c107624cd7
https://doi.org/10.1158/1078-0432.22460595.v1

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Supplementary Figure S4 from pVHL/HIF-Regulated CD70 Expression Is Associated with Infiltration of CD27+ Lymphocytes and Increased Serum Levels of Soluble CD27 in Clear Cell Renal Cell Carcinoma

Autor: Peter Schraml, Holger Moch, Tullio Sulser, Maries van den Broek, Cédric Poyet, Thomas Hermanns, Arndt Hartmann, Anna M. Nowicka, Christiane Mittmann, Melanie Ruf

A) Concentrations of sCD27 in supernatants of 786-O cocultured with different numbers of PBMCs determined by ELISA. B) Western blot of CD70 in 786-O and C) A498 treated with siRNA targeting CD70 (siCD70#1-4) or treated with siRNA control (siScr).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2d17a5aa3c2f56de934bf1acfa6b16
https://doi.org/10.1158/1078-0432.22460586.v1

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Supplementary Tables S1-S4 from pVHL/HIF-Regulated CD70 Expression Is Associated with Infiltration of CD27+ Lymphocytes and Increased Serum Levels of Soluble CD27 in Clear Cell Renal Cell Carcinoma

Autor: Peter Schraml, Holger Moch, Tullio Sulser, Maries van den Broek, Cédric Poyet, Thomas Hermanns, Arndt Hartmann, Anna M. Nowicka, Christiane Mittmann, Melanie Ruf

Supplementary table S1: Antibodies used for Western blot analysis, immunohistochemistry and ChIP. Supplementary table S2: VHL and HIF1α mutation states in cell lines. Supplementary table S3: Primers used for ChIP analysis. Supplementary table S4: Co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ea2a52b28c33c40d0f699502f52d09
https://doi.org/10.1158/1078-0432.22460583

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Supplementary Figure S1 from pVHL/HIF-Regulated CD70 Expression Is Associated with Infiltration of CD27+ Lymphocytes and Increased Serum Levels of Soluble CD27 in Clear Cell Renal Cell Carcinoma

Autor: Peter Schraml, Holger Moch, Tullio Sulser, Maries van den Broek, Cédric Poyet, Thomas Hermanns, Arndt Hartmann, Anna M. Nowicka, Christiane Mittmann, Melanie Ruf

Western blot of 786-O and A498 lysates untreated and treated with PNGase F. NetNGlyc 1.0 Server (http://www.cbs.dtu.dk/services/NetNGlyc/) predicts two N-linked glycosylation sites within the CD70 amino acid sequence. De-glycosylation reduced CD70 ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132b068445282434dcc37adbf1b6b3bb
https://doi.org/10.1158/1078-0432.22460601.v1

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PD-L1 expression is regulated by hypoxia inducible factor in clear cell renal cell carcinoma

Autor: Holger Moch, Melanie Ruf, Peter Schraml

Publikováno v: International Journal of Cancer. 139:396-403

In our study, we demonstrate that ccRCC cell lines with impaired function of pVHL to degrade HIFα express elevated levels of PD-L1. In vitro analysis provided evidence that both reconstitution of pVHL and silencing of HIF2α, but not of HIF1α, lead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b0f424905b5ad7c8ad314f892825945
https://doi.org/10.1002/ijc.30077

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The protein tyrosine phosphatase receptor type J is regulated by the pVHL-HIF axis in clear cell renal cell carcinoma

Autor: Silvia Casagrande, Markus Rechsteiner, Wilhelm Krek, Laura Morra, Adriana von Teichman, Holger Moch, Peter Schraml, Melanie Ruf, Sonja Brun-Schmid

Publikováno v: The Journal of Pathology. 229:525-534

Mass spectrometry analysis of renal cancer cell lines recently suggested that the protein-tyrosine phosphatase receptor type J (PTPRJ), an important regulator of tyrosine kinase receptors, is tightly linked to the von Hippel-Lindau protein (pVHL). Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ec14debd8e560e1fe0787d6e500d4c0
https://doi.org/10.1002/path.4107

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Interaction of tumor cells with infiltrating lymphocytes via CD70 and CD27 in clear cell renal cell carcinoma

Autor: Melanie Ruf, Peter Schraml, Holger Moch

Publikováno v: Oncoimmunology

CD70 upregulation by hypoxia-inducible factor and CD27(+) lymphocyte tumor infiltration are associated with worse survival in von Hippel-Lindau gene (VHL) mutated clear cell renal cell carcinoma (ccRCC). CD70/CD27 interaction is accompanied by high s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187b825618604ca4e27374f52d256919
https://europepmc.org/articles/PMC4635726/

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pVHL/HIF-regulated CD70 expression is associated with infiltration of CD27+ lymphocytes and increased serum levels of soluble CD27 in clear cell renal cell carcinoma

Autor: Cédric Poyet, Anna M. Nowicka, Melanie Ruf, Arndt Hartmann, Christiane Mittmann, Maries van den Broek, Peter Schraml, Thomas Hermanns, Holger Moch, Tullio Sulser

Publikováno v: Clinical Cancer Research

Purpose: CD70, a member of the TNF ligand superfamily, has been shown frequently overexpressed in clear cell renal cell carcinoma (ccRCC). The mechanisms of CD70′s upregulation and its role in ccRCC are unknown. Experimental Design: CD70 expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970fe673e6e0c81fc31e06d264525f35
https://doi.org/10.5167/uzh-111400

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The protein tyrosine phosphatase receptor type J is regulated by the pVHL-HIF axis in clear cell renal cell carcinoma

Autor: Silvia, Casagrande, Melanie, Ruf, Markus, Rechsteiner, Laura, Morra, Sonja, Brun-Schmid, Adriana, von Teichman, Wilhelm, Krek, Peter, Schraml, Holger, Moch

Publikováno v: The Journal of pathology. 229(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa0cec89e0c880404fc3277de87b6e0b
https://pubmed.ncbi.nlm.nih.gov/23007793

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