Bilateral remote ischemic conditioning in children: A two-center, double-blind, randomized controlled trial in young children undergoing cardiac surgeryCentral MessagePerspective

Autor: Nigel E. Drury, PhD, FRCS(CTh), Carin van Doorn, MD, FRCS(CTh), Rebecca L. Woolley, MSc, Rebecca J. Amos-Hirst, MSc, Rehana Bi, BSc(Hons), Collette M. Spencer, BSc(Hons), Kevin P. Morris, MD, FRCPCH, James Montgomerie, MD, FRCA, John Stickley, BSc, Adrian Crucean, MD, Alicia Gill, MSc, Matt Hill, MSc, Ralf J.M. Weber, PhD, Lukas Najdekr, PhD, Andris Jankevics, PhD, Andrew D. Southam, PhD, Gavin R. Lloyd, PhD, Osama Jaber, MD, Imre Kassai, PhD, Giuseppe Pelella, MD, Natasha E. Khan, MD, FRCS(CTh), Phil Botha, PhD, FRCS(CTh), David J. Barron, MD, FRCS(CTh), Melanie Madhani, PhD, Warwick B. Dunn, PhD, Natalie J. Ives, MSc, Paulus Kirchhof, MD, Timothy J. Jones, MD, FRCS(CTh), Edmund D. Carver, Alistair J. Cranston, Fraser Harban, Vasco Laginha Rolo, Ritchie Marcus, Anthony Moriarty, Raju Reddy, Susanna N. Ritchie-McLean, Monica A. Stokes, Ayngara Thillaivasan, Nandlal Bhatia, Carol Bodlani, Wendy Lim, Joe Mellor, Jutta Scheffczik

Publikováno v: JTCVS Open, Vol 18, Iss , Pp 193-208 (2024)

Objective: The study objective was to determine whether adequately delivered bilateral remote ischemic preconditioning is cardioprotective in young children undergoing surgery for 2 common congenital heart defects with or without cyanosis. Methods: W

Externí odkaz: https://doaj.org/article/dff6356b9ff249ccb9d12ee4838ec4a3

Bilateral Remote Ischaemic Conditioning in Children (BRICC) trial: protocol for a two-centre, double-blind, randomised controlled trial in young children undergoing cardiac surgery

Autor: Paulus Kirchhof, Rebecca L Woolley, Natalie J Ives, John Stickley, Timothy J Jones, Nigel E Drury, Kevin P Morris, Carin Van Doorn, Rehana Bi, James Montgomerie, Warwick B Dunn, Melanie Madhani

Publikováno v: BMJ Open, Vol 10, Iss 10 (2020)

Introduction Myocardial protection against ischaemic-reperfusion injury is a key determinant of heart function and outcome following cardiac surgery in children. However, with current strategies, myocardial injury occurs routinely following aortic cr

Externí odkaz: https://doaj.org/article/dc3c75aa75d241828e7cdb3112576f31

Inorganic Nitrate in Angina Study: A Randomized Double‐Blind Placebo‐Controlled Trial

Autor: Konstantin Schwarz, Satnam Singh, Satish K. Parasuraman, Amelia Rudd, Lee Shepstone, Martin Feelisch, Magdalena Minnion, Shakil Ahmad, Melanie Madhani, John Horowitz, Dana K. Dawson, Michael P. Frenneaux

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 9 (2017)

BackgroundIn this double‐blind randomized placebo‐controlled crossover trial, we investigated whether oral sodium nitrate, when added to existing background medication, reduces exertional ischemia in patients with angina. Methods and ResultsSeven

Externí odkaz: https://doaj.org/article/aa1f63b70586470fbf6d41dca39b9800

Bilateral Remote Ischaemic Conditioning in Children (BRICC) trial: protocol for a two-centre, double-blind, randomised controlled trial in young children undergoing cardiac surgery

Autor: Carin van Doorn, Kevin P Morris, John Stickley, Nigel E Drury, Timothy J. Jones, Paulus Kirchhof, James Montgomerie, Rehana Bi, Rebecca Woolley, Natalie Ives, Melanie Madhani, Warwick B. Dunn

Publikováno v: BMJ Open, Vol 10, Iss 10 (2020)
BMJ Open

IntroductionMyocardial protection against ischaemic-reperfusion injury is a key determinant of heart function and outcome following cardiac surgery in children. However, with current strategies, myocardial injury occurs routinely following aortic cro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2aa7a2e6d03e3c97f7bd1055d3b0506
https://bmjopen.bmj.com/content/10/10/e042176.full

Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy

Autor: Monica Sani, Denis M. Grant, Hannah Noordali, Iain R. Greig, Michael P. Frenneaux, Chih-Chung Tseng, Matteo Zanda, Melanie Madhani

Publikováno v: Journal of medicinal chemistry 60 (2017): 2780–2789. doi:10.1021/acs.jmedchem.6b01592
info:cnr-pdr/source/autori:Tseng C.-C.; Noordali H.; Sani M.; Madhani M.; Grant D.M.; Frenneaux M.P.; Zanda M.; Greig I.R./titolo:Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy/doi:10.1021%2Facs.jmedchem.6b01592/rivista:Journal of medicinal chemistry/anno:2017/pagina_da:2780/pagina_a:2789/intervallo_pagine:2780–2789/volume:60

We designed and synthesized perhexiline analogues that have the same therapeutic profile as the parent cardiovascular drug but lacking its metabolic liability associated with CYP2D6 metabolism. Cycloalkyl perhexiline analogues 6a-j were found to be u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e583dbd9a218fb2a396a6a1833291cd0
https://doi.org/10.1021/acs.jmedchem.6b01592