Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Melanie, Korbelius"'
Autor:
Alena Akhmetshina, Valentina Bianco, Ivan Bradić, Melanie Korbelius, Anita Pirchheim, Katharina B. Kuentzel, Thomas O. Eichmann, Helga Hinteregger, Dagmar Kolb, Hansjoerg Habisch, Laura Liesinger, Tobias Madl, Wolfgang Sattler, Branislav Radović, Simon Sedej, Ruth Birner-Gruenberger, Nemanja Vujić, Dagmar Kratky
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101869- (2024)
Objective: Lysosomal acid lipase (LAL) is the only enzyme known to hydrolyze cholesteryl esters (CE) and triacylglycerols in lysosomes at an acidic pH. Despite the importance of lysosomal hydrolysis in skeletal muscle (SM), research in this area is l
Externí odkaz:
https://doaj.org/article/121b95e681f74b8e83bd5774d9dcc210
Autor:
Valentina Bianco, Melanie Korbelius, Nemanja Vujic, Alena Akhmetshina, Melina Amor, Dagmar Kolb, Anita Pirchheim, Ivan Bradic, Katharina B. Kuentzel, Martin Buerger, Silvia Schauer, Huyen T.T. Phan, Dominik Bulfon, Gerald Hoefler, Robert Zimmermann, Dagmar Kratky
Publikováno v:
Molecular Metabolism, Vol 73, Iss , Pp 101737- (2023)
Objective: To date, the only enzyme known to be responsible for the hydrolysis of cholesteryl esters and triacylglycerols in the lysosome at acidic pH is lysosomal acid lipase (LAL). Lipid malabsorption in the small intestine (SI), accompanied by mac
Externí odkaz:
https://doaj.org/article/56fe92f78f8e4d238b80e8bd6cd05e8b
Autor:
Yu Sun, Hadrien Demagny, Adrien Faure, Francesca Pontanari, Antoine Jalil, Nadia Bresciani, Ece Yildiz, Melanie Korbelius, Alessia Perino, Kristina Schoonjans
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)
The nonessential amino acid asparagine can only be synthesized de novo by the enzymatic activity of asparagine synthetase (ASNS). While ASNS and asparagine have been implicated in the response to numerous metabolic stressors in cultured cells, the in
Externí odkaz:
https://doaj.org/article/eb763ef9953c42d3ac3eebba53634aa7
Autor:
Qishun Zhou, Fangrong Zhang, Jakob Kerbl-Knapp, Melanie Korbelius, Katharina Barbara Kuentzel, Nemanja Vujić, Alena Akhmetshina, Gerd Hörl, Margret Paar, Ernst Steyrer, Dagmar Kratky, Tobias Madl
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1270 (2022)
Phospholipid metabolism, including phosphatidylcholine (PC) biosynthesis, is crucial for various biological functions and is associated with longevity. Phosphatidylethanolamine N-methyltransferase (PEMT) is a protein that catalyzes the biosynthesis o
Externí odkaz:
https://doaj.org/article/1d27ec3fb60847da8797678be05c86db
Publikováno v:
Trends Mol Med
Lysosomal acid lipase (LAL) is the sole enzyme known to degrade neutral lipids in the lysosome. Mutations in the LAL-encoding LIPA gene lead to rare lysosomal lipid storage disorders with complete or partial absence of LAL activity. This review discu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5510d8b7e199b32cb7e3afb2e6924c0
https://doi.org/10.1016/j.molmed.2023.03.001
https://doi.org/10.1016/j.molmed.2023.03.001
Autor:
Fangrong Zhang, Jakob Kerbl-Knapp, Maria J. Rodriguez Colman, Andreas Meinitzer, Therese Macher, Nemanja Vujić, Sandra Fasching, Evelyne Jany-Luig, Melanie Korbelius, Katharina B. Kuentzel, Maximilian Mack, Alena Akhmetshina, Anita Pirchheim, Margret Paar, Beate Rinner, Gerd Hörl, Ernst Steyrer, Ulrich Stelzl, Boudewijn Burgering, Tobias Eisenberg, Brigitte Pertschy, Dagmar Kratky, Tobias Madl
Publikováno v:
Cell Reports: Methods, Vol 1, Iss 2, Pp 100016- (2021)
Summary: Quantitative information about the levels and dynamics of post-translational modifications (PTMs) is critical for an understanding of cellular functions. Protein arginine methylation (ArgMet) is an important subclass of PTMs and is involved
Externí odkaz:
https://doaj.org/article/6d74bd3fefba487aa0dcd5a2f0f8bbda
Autor:
Madeleine Goeritzer, Stefanie Schlager, Katharina B. Kuentzel, Nemanja Vujić, Melanie Korbelius, Silvia Rainer, Dagmar Kolb, Marion Mussbacher, Manuel Salzmann, Waltraud C. Schrottmaier, Alice Assinger, Axel Schlagenhauf, Corina T. Madreiter-Sokolowski, Sandra Blass, Thomas O. Eichmann, Wolfgang F. Graier, Dagmar Kratky
Publikováno v:
Cells, Vol 11, Iss 5, p 850 (2022)
According to genome-wide RNA sequencing data from human and mouse platelets, adipose triglyceride lipase (ATGL), the main lipase catalyzing triglyceride (TG) hydrolysis in cytosolic lipid droplets (LD) at neutral pH, is expressed in platelets. Curren
Externí odkaz:
https://doaj.org/article/a161f0b541984c52ab20b2cc71855bf1
Autor:
Qishun Zhou, Jakob Kerbl-Knapp, Fangrong Zhang, Melanie Korbelius, Katharina Barbara Kuentzel, Nemanja Vujić, Alena Akhmetshina, Gerd Hörl, Margret Paar, Ernst Steyrer, Dagmar Kratky, Tobias Madl
Publikováno v:
Metabolites, Vol 12, Iss 1, p 17 (2021)
Energy metabolism, including alterations in energy intake and expenditure, is closely related to aging and longevity. Metabolomics studies have recently unraveled changes in metabolite composition in plasma and tissues during aging and have provided
Externí odkaz:
https://doaj.org/article/020d70e6ce124613953e12aec8f5e359
Autor:
Vinay Sachdev, Madalina Duta-Mare, Melanie Korbelius, Nemanja Vujić, Christina Leopold, Jan Freark de Boer, Silvia Rainer, Peter Fickert, Dagmar Kolb, Folkert Kuipers, Branislav Radovic, Gregor Gorkiewicz, Dagmar Kratky
Publikováno v:
Cells, Vol 10, Iss 10, p 2619 (2021)
Lysosomal acid lipase (LAL) is the sole enzyme known to be responsible for the hydrolysis of cholesteryl esters and triglycerides at an acidic pH in lysosomes, resulting in the release of unesterified cholesterol and free fatty acids. However, the ro
Externí odkaz:
https://doaj.org/article/0f846bafb7e340859b3eaa4516f431ba
Autor:
Melanie Korbelius, Nemanja Vujic, Vinay Sachdev, Sascha Obrowsky, Silvia Rainer, Benjamin Gottschalk, Wolfgang F. Graier, Dagmar Kratky
Publikováno v:
Cell Reports, Vol 28, Iss 7, Pp 1923-1934.e4 (2019)
Summary: As circulating lipid levels are balanced by the rate of lipoprotein release and clearance from the plasma, lipid absorption in the small intestine critically contributes to the maintenance of whole-body lipid homeostasis. Within enterocytes,
Externí odkaz:
https://doaj.org/article/a4742c9cc05945e782afeea75541f01a