Supplementation with Bifidobacterium longum subspecies infantis EVC001 for mitigation of type 1 diabetes autoimmunity: the GPPAD-SINT1A randomised controlled trial protocol

Autor: Matthew D Snape, Melanie Gündert, Anette-Gabriele Ziegler, Peter Achenbach, Reinhard Berner, Kristina Casteels, Thomas Danne, Joerg Hasford, Olga Kordonouri, Karin Lange, Helena Elding Larsson, Markus Lundgren, Agnieszka Szypowska, John A Todd, Ezio Bonifacio, Nicole Zubizarreta, Christiane Winkler, Åke Lernmark, Daniel Agardh, Cigdem Gezginci, Claudia Ramminger, Marlon Scholz, Katharina Warncke, Carin Andrén Aronsson, Rasmus Bennet, Lina Fransson, Zeliha Mestan, Caroline Nilsson, Anita Ramelius, Carina Törn, Sarah Hogg, Catherine Owen, Lidia Groele, Florian Haupt, Claudia Matzke, Robin Assfalg, Matthew Snape, Felix Reschke, Marcin L Pekalski, Andreas Weiss, Andrew Johnston, Manja Jolink, Loredana Marcovecchio, Mariusz Ołtarzewski, Stefanie Arnolds, Annika Kölln, Markus Pfirrmann, Corinna Barz, Karina Blasius, Nadine Friedl, Adriano Gomez-Bantel, Martin Heigermoser, Bianca Höfelschweiger, Nadine Klein, Ramona Lickert, Rebecca Niewöhner, Katharina Schütte-Borkovec, Mira Taulien, Lara Vogel, Franziska Voß, José Maria Zapardiel Gonzalo, Philipp Sifft, Heidi Kapfelsberger, Merve Vurucu, Katharina Sarcletti, Stefanie Jacobson, Yulia Grinin, John A. Todd, Anette-G. Ziegler, Marcin L. Pekalski, Anette G. Ziegler, Annre Rochtus, An Jacobs, Hilde Morobé, Jasmin Paulus, Brontë Vrancken, Natalie Van den Driessche, Renka Van Heyste, Janne Houben, Veerle Vanhuyse, Sevina Dietz, Gita Gemulla, Manja Gottschalk-Schwarz, Sophie Heinke, Angela Hommel, Susann Kowal, Fabian Lander, Robert Morgenstern, Marc Weigelt, Sari Arabi, Raphael Hoffmann, Ruth Blechschmidt, Franziska Ehrlich, Anja Loff, Laura Galuschka, Ute Holtkamp, Nils Janzen, Sarah Landsberg, Erika Marquardt, Frank Roloff, Kerstin Semler, Thekla von dem Berge, Melanie Bunk, Simone Färber-Meisterjahn, Willi Grätz, Ines Greif, Melanie Herbst, Anna Hofelich, Benjamin Marcus, Annette Munzinger, Jasmin Ohli, Franziska Reinmüller, Tiziana Welzhofer, Sylwia Dybkowska, Katarzyna Dżygało, Dorota Owczarek, Katarzyna Popko, Agnieszka Skrobot, Anna Taczanowska, Beata Zduńczyk, Charlotte Brundin, Ida Jönsson, Sara Maroufkhani, Evelyn Tekum Amboh, Katarzyna Gajewska-Knapik, Elena Romero, Suzannah Twiss, Helen Gallon, Laura Gebbie, Fiona Jenkinson, Steven Pratt, Steve Robson, Claire Simmister, Evelyn Thomson, Eileen Walton

Publikováno v: BMJ Open, Vol 11, Iss 11 (2021)

Introduction The Global Platform for the Prevention of Autoimmune Diabetes-SINT1A Study is designed as a randomised, placebo-controlled, double-blind, multicentre, multinational, primary prevention study aiming to assess whether daily administration

Externí odkaz: https://doaj.org/article/32b6df3b92764c4e9ef877d2ae7501a4

Efficacy of vildagliptin for prevention of postpartum diabetes in women with a recent history of insulin-requiring gestational diabetes: A phase II, randomized, double-blind, placebo-controlled study

Autor: Sandra Hummel, Andreas Beyerlein, Markus Pfirrmann, Anna Hofelich, Daniela Much, Susanne Hivner, Melanie Bunk, Melanie Herbst, Claudia Peplow, Markus Walter, Denise Kohn, Nadine Hummel, Jürgen Kratzsch, Michael Hummel, Martin Füchtenbusch, Joerg Hasford, Anette-G. Ziegler, Heike Börschmann, Sophia Ebe, Eleni Giannopoulou, Minna Harsunen, Veronika Hofbauer, Andrea Schuppenies, Maike Wallner, David Wiesenäcker, Stephanie Zillmer, Lorenz Lachmann, Rüdiger Landgraf, Karl-Theo Maria Schneider, Elisabeth André, Viktoria Janke, Ezio Bonifacio

Publikováno v: Molecular Metabolism, Vol 9, Iss , Pp 168-175 (2018)

Objective: Women with insulin-requiring gestational diabetes mellitus (GDM) are at high risk of developing diabetes within a few years postpartum. We implemented this phase II study to test the hypothesis that vildagliptin, a dipeptidyl peptidase-4 i

Externí odkaz: https://doaj.org/article/635c2bfed81846888df968d30e3d0269

Intergenerational Metabolomic Analysis of Mothers with a History of Gestational Diabetes Mellitus and Their Offspring

Autor: Raffael Ott, Sandra Hummel, Andreas Weiß, Anette-G. Ziegler, Werner Römisch-Margl, Nadine Hummel, Gabi Kastenmüller, Anna Hofelich, Jerzy Adamski, Melanie Herbst, Xenia Pawlow, Cornelia Prehn

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 9647, p 9647 (2020)
Volume 21
Issue 24
Int. J. Mol. Sci. 21:9647 (2020)

Shared metabolomic patterns at delivery have been suggested to underlie the mother-to-child transmission of adverse metabolic health. This study aimed to investigate whether mothers with gestational diabetes mellitus (GDM) and their offspring show si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62892b50ef7daed9f2f96c1a6577ab6a
https://pubmed.ncbi.nlm.nih.gov/33348910

Recruiting young pre-symptomatic children for a clinical trial in type 1 diabetes: Insights from the Fr1da insulin intervention study

Autor: Stefanie Tretter, Susanne Aydin, Melanie Bunk, Nicole Nellen-Hellmuth, Susanne Bechtold-Dalla Pozza, U Kuhnle-Krahl, Sonja Braig, Robin Assfalg, Kerstin Kick, Peter Achenbach, Melanie Heinrich, Verena S. Hoffmann, Desiree Dunstheimer, Eva Maria Gerstl, Herbert Müller, Marina Sindichakis, Claudia Ramminger, Yvonne Kriesen, Melanie Herbst, Uwe Ermer, Antonia Gavazzeni, Christian Ockert, Alevtina Durmashkina, Katharina Warncke, Anette-G. Ziegler, Dominik Böcker

Publikováno v: Contemp. Clin. Trails Comm. 11, 170-173 (2018)
Contemporary Clinical Trials Communications
Contemporary Clinical Trials Communications, Vol 11, Iss, Pp 170-173 (2018)

Background: Although detection of children at high risk of developing type 1 diabetes and diagnosis of early stages is possible, up to now there exists no approved therapy to delay or prevent type 1 diabetes. Thus it is vital to develop evidence-base

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d58d9243831dab1816cfc8c6de88433
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=54208

Construction of a 30kW SOFC Gas Turbine Hybrid Power Plant

Autor: K. Andreas Friedrich, Andreas Huber, Martina Hohloch, Josef Kallo, Mike Steilen, Moritz Henke, Marc Riedel, Christian Schnegelberger, Melanie Herbst, Sandro Bücheler

Publikováno v: ECS Transactions. 68:85-88

Hybrid power plants consisting of a gas turbine coupled with solid oxide fuel cells (SOFC) convert chemically bound energy into electrical energy. They can be operated at higher electrical efficiencies than conventional power plants. Theoretical stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aadad43fad035fd29839f6a02596ba40
https://doi.org/10.1149/06801.0085ecst