Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Melanie, Grandits"'
Autor:
Vera E. van der Noord, Wanda van der Stel, Gijs Louwerens, Danielle Verhoeven, Hendrik J. Kuiken, Cor Lieftink, Melanie Grandits, Gerhard F. Ecker, Roderick L. Beijersbergen, Peter Bouwman, Sylvia E. Le Dévédec, Bob van de Water
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-20 (2023)
Abstract Background Triple-negative breast cancer (TNBC) is a subtype of breast cancer with limited treatment options and poor clinical prognosis. Inhibitors of transcriptional CDKs are currently under thorough investigation for application in the tr
Externí odkaz:
https://doaj.org/article/3cd3539eec0948958a3e708b71d4da89
Autor:
Jitesh Chauhan, Melanie Grandits, Lais C. G. F. Palhares, Silvia Mele, Mano Nakamura, Jacobo López-Abente, Silvia Crescioli, Roman Laddach, Pablo Romero-Clavijo, Anthony Cheung, Chara Stavraka, Alicia M. Chenoweth, Heng Sheng Sow, Giulia Chiaruttini, Amy E. Gilbert, Tihomir Dodev, Alexander Koers, Giulia Pellizzari, Kristina M. Ilieva, Francis Man, Niwa Ali, Carl Hobbs, Sara Lombardi, Daniël A. Lionarons, Hannah J. Gould, Andrew J. Beavil, Jenny L. C. Geh, Alastair D. MacKenzie Ross, Ciaran Healy, Eduardo Calonje, Julian Downward, Frank O. Nestle, Sophia Tsoka, Debra H. Josephs, Philip J. Blower, Panagiotis Karagiannis, Katie E. Lacy, James Spicer, Sophia N. Karagiannis, Heather J. Bax
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Outcomes for half of patients with melanoma remain poor despite standard-of-care checkpoint inhibitor therapies. The prevalence of the melanoma-associated antigen chondroitin sulfate proteoglycan 4 (CSPG4) expression is ~70%, therefore effec
Externí odkaz:
https://doaj.org/article/eeac938a111045e186e031edbfe48da6
Publikováno v:
Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-9 (2022)
Abstract Machine learning (ML) models require an extensive, user-driven selection of molecular descriptors in order to learn from chemical structures to predict actives and inactives with a high reliability. In addition, privacy concerns often restri
Externí odkaz:
https://doaj.org/article/d34df7530e724a839f7f18d4c1355394
Autor:
Melanie Grandits, Clemens Grünwald-Gruber, Silke Gastine, Joseph F. Standing, Rajko Reljic, Audrey Y-H. Teh, Julian K-C. Ma
Publikováno v:
Frontiers in Plant Science, Vol 14 (2023)
IntroductionBroadly neutralising antibodies are promising candidates for preventing and treating Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS), as an alternative to or in combination with antiretroviral therapy (ART). The
Externí odkaz:
https://doaj.org/article/a6da8d8629ee41708cf5684e2171cee8
Autor:
Kathrin Göritzer, Melanie Grandits, Clemens Grünwald-Gruber, Rudolf Figl, Sébastien Mercx, Catherine Navarre, Julian K-C. Ma, Audrey Y-H. Teh
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
Molecular pharming in plants offers exciting possibilities to address global access to modern biologics. However, differences in the N-glycosylation pathway including the presence of β(1,2)-xylose and core α(1,3)-fucose can affect activity, potency
Externí odkaz:
https://doaj.org/article/f5ca13225d094f4b86c70ce5aa04f9eb
Autor:
Catherine M. Moore, Melanie Grandits, Clemens Grünwald-Gruber, Friedrich Altmann, Maria Kotouckova, Audrey Y.-H. Teh, Julian K.-C. Ma
Publikováno v:
Retrovirology, Vol 18, Iss 1, Pp 1-11 (2021)
Abstract Background HIV remains one of the most important health issues worldwide, with almost 40 million people living with HIV. Although patients develop antibodies against the virus, its high mutation rate allows evasion of immune responses. Some
Externí odkaz:
https://doaj.org/article/532945d190584a4fbbc6b1672293722a
Autor:
Alex J. McCraw, Richard A. Gardner, Anna M. Davies, Daniel I. R. Spencer, Melanie Grandits, Gerd K. Wagner, James M. McDonnell, Sophia N. Karagiannis, Alicia Chenoweth, Silvia Crescioli
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13455 (2022)
Efficient characterization of IgE antibodies and their glycan structures is required for understanding their function in allergy and in the emerging AllergoOncology field for antibody immunotherapy. We report the generation, glyco-profiling and funct
Externí odkaz:
https://doaj.org/article/1a3110b271c1475cb13a0293f2eea315
Autor:
Debra H Josephs, Giulia Pellizzari, Olivier Martinez, Silvia Crescioli, Robert Page, Ashley Di Meo, Silvia Mele, Giulia Chiaruttini, Jan Hoinka, Ihor Batruch, Ioannis Prassas, Melanie Grandits, Jacobo López-Abente, Eva Bugallo-Blanco, Malcolm Ward, Heather J Bax, Elise French, Anthony Cheung, Sara Lombardi, Mariangela Figini, Katie E Lacy, Eleftherios P Diamandis
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background Cancer immunotherapy with monoclonal antibodies and chimeric antigen receptor (CAR) T cell therapies can benefit from selection of new targets with high levels of tumor specificity and from early assessments of efficacy and safety to deris
Externí odkaz:
https://doaj.org/article/836d29985b964cc8b16ff8085298d717
Autor:
Floriane Montanari, Bernhard Knasmüller, Stefan Kohlbacher, Christoph Hillisch, Christine Baierová, Melanie Grandits, Gerhard F. Ecker
Publikováno v:
Frontiers in Chemistry, Vol 7 (2020)
Transporters expressed in the liver play a major role in drug pharmacokinetics and are a key component of the physiological bile flow. Inhibition of these transporters may lead to drug-drug interactions or even drug-induced liver injury. Therefore, p
Externí odkaz:
https://doaj.org/article/5c33b9365c564845b234af12294afa02
Autor:
Jitesh Chauhan, Chara Stavraka, Melanie Grandits, Lais C. G. F. Palhares, Debra H. Josephs, Katie E. Lacy, James Spicer, Heather J. Bax, Sophia N. Karagiannis
Publikováno v:
Cells, Vol 11, Iss 3, p 438 (2022)
Despite comprising a very small proportion of circulating blood leukocytes, basophils are potent immune effector cells. The high-affinity receptor for IgE (FcɛRI) is expressed on the basophil cell surface and powerful inflammatory mediators such as
Externí odkaz:
https://doaj.org/article/fe3f07ce92bb4050b96a67c7b3dbf11d