Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Melanie, Dimapasoc"'
Autor:
Melanie Dimapasoc, Jose Moran, Steve Cole, Alok Ranjan, Rami Hourani, Jocelyn Kim, Paul Wender, Matthew Marsden, Jerome Zack
Publikováno v:
Pathogens and Immunity, Vol 9, Iss 1 (2024)
Background: Latency reversing agents (LRAs) such as protein kinase C (PKC) modulators can reduce rebound-competent HIV reservoirs in small animal models. Furthermore, administration of natural killer (NK) cells following LRA treatment improves this r
Externí odkaz:
https://doaj.org/article/b28795ccc8294c6cb9c59f2b4d84955c
Autor:
Jocelyn T. Kim, Tian-Hao Zhang, Camille Carmona, Bryanna Lee, Christopher S. Seet, Matthew Kostelny, Nisarg Shah, Hongying Chen, Kylie Farrell, Mohamed S. A. Soliman, Melanie Dimapasoc, Michelle Sinani, Kenia Yazmin Reyna Blanco, David Bojorquez, Hong Jiang, Yuan Shi, Yushen Du, Natalia L. Komarova, Dominik Wodarz, Paul A. Wender, Matthew D. Marsden, Ren Sun, Jerome A. Zack
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Here, Kim et al. describe a new kick and kill strategy utilizing a single administration of a protein kinase C modulator and latency reversing agent in combination with injections of allogeneic peripheral blood natural killer cells diminishes the HIV
Externí odkaz:
https://doaj.org/article/7b9b98b368d54eccabea67b1cb3df389
Autor:
Lars Pache, Matthew D. Marsden, Peter Teriete, Alex J. Portillo, Dominik Heimann, Jocelyn T. Kim, Mohamed S.A. Soliman, Melanie Dimapasoc, Camille Carmona, Maria Celeridad, Adam M. Spivak, Vicente Planelles, Nicholas D.P. Cosford, Jerome A. Zack, Sumit K. Chanda
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 3, Pp 100037- (2020)
Summary: “Shock and kill” strategies focus on purging the latent HIV-1 reservoir by treating infected individuals with therapeutics that activate the latent virus and subsequently eliminating infected cells. We have previously reported that induc
Externí odkaz:
https://doaj.org/article/844b2284d4654ae7b526e217e79fb151
Autor:
Shannon Kelly, Evan S Jacobs, Mars Stone, Sheila M Keating, Tzong-Hae Lee, Daniel Chafets, John Heitman, Melanie Dimapasoc, Eva Operskalski, Ward Hagar, Elliott Vichinsky, Michael P Busch, Philip J Norris, Brian Custer, Recipient Epidemiology and Donor Evaluation Study (REDS-III)
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0218880 (2020)
People with sickle cell disease (SCD) are reported to have low rates of HIV infection, slower progression to AIDS and lower HIV-associated mortality compared to the general population. Mechanisms of potential resistance to HIV in SCD are incompletely
Externí odkaz:
https://doaj.org/article/cf2e5f2095cc40c79070e2ba6fcd672f
Autor:
Daniel I S Rosenbloom, Peter Bacchetti, Mars Stone, Xutao Deng, Ronald J Bosch, Douglas D Richman, Janet D Siliciano, John W Mellors, Steven G Deeks, Roger G Ptak, Rebecca Hoh, Sheila M Keating, Melanie Dimapasoc, Marta Massanella, Jun Lai, Michele D Sobolewski, Deanna A Kulpa, Michael P Busch, Reservoir Assay Validation and Evaluation Network (RAVEN) Study Group
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 4, p e1006849 (2019)
Quantitative viral outgrowth assays (QVOA) use limiting dilutions of CD4+ T cells to measure the size of the latent HIV-1 reservoir, a major obstacle to curing HIV-1. Efforts to reduce the reservoir require assays that can reliably quantify its size
Externí odkaz:
https://doaj.org/article/b5955aac1a054bdaae557617f2bee089
Autor:
Peter Bacchetti, Carol Lackman-Smith, Mars Stone, Sheila M. Keating, Xutao Deng, Douglas D. Richman, Nicolas Chomont, Michael P. Busch, Amélie Pagliuzza, Roger G. Ptak, Subul A. Beg, Daniel I. S. Rosenbloom, Sonia Bakkour, Melanie Dimapasoc, John W. Mellors, Steven G. Deeks, Janet D. Siliciano, Jun Lai
Publikováno v:
The Journal of Infectious Diseases
Background Evaluations of human immunodeficiency virus (HIV) curative interventions require reliable and efficient quantification of replication-competent latent reservoirs. The “classic” quantitative viral outgrowth assay (QVOA) has been regarde
Autor:
Peter Teriete, Matthew D. Marsden, Jerome A. Zack, Vicente Planelles, Camille Carmona, Sumit K. Chanda, Dominik Heimann, Adam M. Spivak, Maria Celeridad, Nicholas D. P. Cosford, Lars Pache, Jocelyn T. Kim, Mohamed S.A. Soliman, Alex J. Portillo, Melanie Dimapasoc
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 3, Pp 100037-(2020)
Cell Reports Medicine
Cell Reports Medicine
Summary “Shock and kill” strategies focus on purging the latent HIV-1 reservoir by treating infected individuals with therapeutics that activate the latent virus and subsequently eliminating infected cells. We have previously reported that induct
Autor:
Melanie Dimapasoc, Nancy L. Benner, Jerome A. Zack, Xiaomeng Wu, Matthew D. Marsden, Xiaoyu Zang, Mohamed S.A. Soliman, Paul A. Wender, Tae-Wook Chun, Jack L. Sloane, Katherine N Keenan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 20
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
AIDS is a pandemic disease caused by HIV that affects 37 million people worldwide. Current antiretroviral therapy slows disease progression but does not eliminate latently infected cells, which resupply active virus, thus necessitating lifelong treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ed3ae55e55c15a805936523dea10c4
https://escholarship.org/uc/item/3wh7v0tp
https://escholarship.org/uc/item/3wh7v0tp
Autor:
Ren Sun, Yushen Du, Xiaomeng Wu, Tian-hao Zhang, Akira J. Shimizu, Adam J. Schrier, Jocelyn T. Kim, Paul A. Wender, Melanie Dimapasoc, Mohamed S.A. Soliman, Jerome A. Zack, Matthew D. Marsden
Publikováno v:
Cell Reports Medicine
Summary HIV latency prevents cure of infection with antiretroviral therapy (ART) alone. One strategy for eliminating latently infected cells involves the induction of viral protein expression via latency-reversing agents (LRAs), allowing killing of h
Autor:
Eva Operskalski, Elliott Vichinsky, Recipient Epidemiology, Daniel M. Chafets, Tzong-Hae Lee, John W. Heitman, Michael P. Busch, Sheila M. Keating, Ward Hagar, Mars Stone, Philip J. Norris, Shannon Kelly, Brian Custer, Evan S. Jacobs, Melanie Dimapasoc
Publikováno v:
PloS one, vol 15, iss 4
PLoS ONE
PLoS ONE, Vol 15, Iss 4, p e0218880 (2020)
PLoS ONE
PLoS ONE, Vol 15, Iss 4, p e0218880 (2020)
People with sickle cell disease (SCD) are reported to have low rates of HIV infection, slower progression to AIDS and lower HIV-associated mortality compared to the general population. Mechanisms of potential resistance to HIV in SCD are incompletely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bedc92fcba999e3931214765d1da0f4
https://escholarship.org/uc/item/3xk4m2mr
https://escholarship.org/uc/item/3xk4m2mr