Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Melaney Bouthillette"'
Autor:
Manfred Kraus, Yuxun Wang, Dan Aleksandrowicz, Eric Bachman, Alexander A Szewczak, Deborah Walker, Lin Xu, Melaney Bouthillette, Kaleen M Childers, Brian Dolinski, Andrew M Haidle, Johnny Kopinja, Linda Lee, Jongwon Lim, Kevin D Little, Yanhong Ma, Anjili Mathur, Jan-Rung Mo, Erin O'Hare, Ryan D Otte, Brandon M Taoka, Wenxian Wang, Hong Yin, Anna A Zabierek, Weisheng Zhang, Shuxia Zhao, Joe Zhu, Jonathan R Young, C Gary Marshall
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37207 (2012)
A high percentage of patients with the myeloproliferative disorder polycythemia vera (PV) harbor a Val617→Phe activating mutation in the Janus kinase 2 (JAK2) gene, and both cell culture and mouse models have established a functional role for this
Externí odkaz:
https://doaj.org/article/e1af821b8d2243da83151c870eaab2ae
Autor:
Lin Xu, Grace Chan, Melaney Bouthillette, Craig Rosenstein, Sathyajith E. Kumarasinghe, C. Gary Marshall, Tony Siu, Anjili Mathur, Alan B. Northrup, Michael D. Altman, Christopher J. Dinsmore, Matthew H. Katcher, Catherine White, Eric Bachman, Jonathan R. Young
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:1466-1471
This communication discusses the discovery of novel reverse tricyclic pyridones as inhibitors of Janus kinase 2 (JAK2). By using a kinase cross screening approach coupled with molecular modeling, a unique inhibitor–water interaction was discovered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019b05288f9a265bdc23c81724b809ed
https://doi.org/10.1016/j.bmcl.2014.02.011
https://doi.org/10.1016/j.bmcl.2014.02.011
Autor:
Thomas S. Rush, Lin Xu, Paul Tempest, Grace Chan, Eric Bachman, Melaney Bouthillette, Craig Rosenstein, Anjili Mathur, Anna A. Zabierek, Andrew M. Haidle, Kaleen Konrad Childers, Jonathan R. Young, Jan-Rung Mo, Michael D. Altman, C. Gary Marshall
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(8)
A series of carboxamide-substituted thiophenes demonstrating inhibition of JAK2 is described. Development of this chemical series began with the bioisosteric replacement of a urea substituent by a pyridyl ring. Issues of chemical and metabolic stabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8479eda3c03567a3d0c98a3784b3649a
https://pubmed.ncbi.nlm.nih.gov/24666646
https://pubmed.ncbi.nlm.nih.gov/24666646
Autor:
Thomas S. Rush, Michael D. Altman, Christopher J. Dinsmore, Melaney Bouthillette, Jonathan R. Young, Tony Siu, Joon Jung, Anjili Mathur, Lin Xu, Grace Chan, Craig Rosenstein, Jan-Rung Mo, Eric Bachman, C. Gary Marshall, Ekaterina S. Kozina
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(24)
This paper describes the discovery and design of a novel class of JAK2 inhibitors. Furthermore, we detail the optimization of a screening hit using ligand binding efficiency and log D. These efforts led to the identification of compound 41, which dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a07a5c222c4bd5e1d8c727cb4e71e8
https://pubmed.ncbi.nlm.nih.gov/21044843
https://pubmed.ncbi.nlm.nih.gov/21044843
Autor:
Melaney Bouthillette, Lin Xu, Brian Dolinski, C. Gary Marshall, Andrew M. Haidle, Kevin D. Little, Hong Yin, Anjili Mathur, Linda Lee, Shuxia Zhao, Alexander A. Szewczak, Weisheng Zhang, Yanhong Ma, Brandon M. Taoka, Erin O’Hare, Wenxian Wang, Eric Bachman, Jan-Rung Mo, Johnny E. Kopinja, Jongwon Lim, Joe Zhu, Anna A. Zabierek, Deborah Walker, Kaleen M. Childers, Jonathan R. Young, Yuxun Wang, Manfred Kraus, Dan Aleksandrowicz, Ryan D. Otte
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37207 (2012)
PLoS ONE
PLoS ONE
A high percentage of patients with the myeloproliferative disorder polycythemia vera (PV) harbor a Val617→Phe activating mutation in the Janus kinase 2 (JAK2) gene, and both cell culture and mouse models have established a functional role for this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b12cd664d94ab2d9e6db2bc128d6fd
https://doi.org/10.1371/journal.pone.0037207
https://doi.org/10.1371/journal.pone.0037207