Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Melalie Keita"'
Autor:
Boris D. Bekono, Akori E. Esmel, Brice Dali, Fidele Ntie-Kang, Melalie Keita, Luc C. O. Owono, Eugene Megnassan
Publikováno v:
Scientia Pharmaceutica, Vol 89, Iss 4, p 44 (2021)
In this work, antiparasitic peptidomimetics inhibitors (PEP) of falcipain-3 (FP3) of Plasmodium falciparum (Pf) are proposed using structure-based and computer-aided molecular design. Beginning with the crystal structure of PfFP3-K11017 complex (PDB
Externí odkaz:
https://doaj.org/article/e9b79a5d1a054cfcac5f2eab08db0c47
Publikováno v:
Tuberculosis Research and Treatment, Vol 2013 (2013)
We design here new nanomolar antituberculotics, inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase (TMPKmt), by means of structure-based molecular design. 3D models of TMPKmt-inhibitor complexes have been prepared from the crysta
Externí odkaz:
https://doaj.org/article/9ce2690a56014348ae5e531556571dad
Autor:
Eugene Megnassan, Akori Esmel, Yvon Bibila Misseyou, Melalie Keita, Djako Akassa Marius Bernard
Publikováno v:
Journal of Pharmaceutical Research International. :12-41
Aims: Polyketide synthase 13 (Pks13) is an essential enzyme in the synthesis of mycolic acids biosynthesis pathway of Mycobacterium tuberculosis (Mtb). Therefore, Pks13 is a promising drug target for tuberculosis treatment. Here we report the in sili
Autor:
Cecile Bieri, Akori Esmel, Melalie Keita, Luc Calvin Owono Owono, Brice Dali, Eugene Megnassan, Stanislav Miertus, Vladimir Frecer
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 6916
Cost-effective therapy of neglected and tropical diseases such as malaria requires everlasting drug discovery efforts due to the rapidly emerging drug resistance of the plasmodium parasite. We have carried out computational design of new inhibitors o
Autor:
Melalie Keita, Raymond Kre N'Guessan, Stanislav Miertus, Vladimir Frecer, Koffi N'Guessan Placide Gabin Allangba, Eugene Megnassan
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 547-561 (2019)
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 547-561 (2019)
We report computer-aided design of new lactone–chalcone and isatin–chalcone (HLCIC) inhibitors of the falcipain-2 (PfFP-2). 3D models of 15 FP-2:HLCIC1-15 complexes with known observed activity (IC 50 exp) were prepared to establish a quantitativ
Autor:
Koffi Charles, Kouman, Melalie, Keita, Raymond, Kre N'Guessan, Luc Calvin, Owono Owono, Eugene, Megnassan, Vladimir, Frecer, Stanislav, Miertus
Publikováno v:
International Journal of Molecular Sciences
Background: During the previous decade a new class of benzamide-based inhibitors of 2-trans enoyl-acyl carrier protein reductase (InhA) of Mycobacterium tuberculosis (Mt) with unusual binding mode have emerged. Here we report in silico design and eva
Autor:
Melalie Keita, Eugene Megnassan, Raymond Kre N'Guessan, Luc C. Owono Owono, Stanislav Miertus, Vladimir Frecer, Koffi Charles Kouman
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4730 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 19
International Journal of Molecular Sciences
Volume 20
Issue 19
Background: During the previous decade a new class of benzamide-based inhibitors of 2-trans enoyl-acyl carrier protein reductase (InhA) of Mycobacterium tuberculosis (Mt) with unusual binding mode have emerged. Here we report in silico design and eva
Autor:
Vladimir Frecer, Yao Thomas N'Guessan, Mawa Kone, Akori Esmel, Melalie Keita, Eugene Megnassan, Affiba Florance Kouassi, Stanislav Miertus
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 12, Pp 29744-29771 (2015)
International Journal of Molecular Sciences
Volume 16
Issue 12
Pages 29744-29771
International Journal of Molecular Sciences; Volume 16; Issue 12; Pages: 29744-29771
International Journal of Molecular Sciences
Volume 16
Issue 12
Pages 29744-29771
International Journal of Molecular Sciences; Volume 16; Issue 12; Pages: 29744-29771
We have carried out a computational structure-based design of new potent pyrrolidine carboxamide (PCAMs) inhibitors of enoyl-acyl carrier protein reductase (InhA) of Mycobacterium tuberculosis (MTb). Three-dimensional (3D) models of InhA-PCAMx comple
Autor:
Megnassan Eugene, Vladimir Frecer, Akori Esmel, Beguemsi Toi, Melalie Keita, Sift Desk, Eugene Megnassan, Stanislav Miertus
Publikováno v:
SDRP Journal of Computational Chemistry & Molecular Modelling. 2
Autor:
Mohammad Imran Siddiqi, Stanislav Miertus, Melalie Keita, Vladimir Frecer, Brice Dali, Eugene Megnassan, A. Kumar
Publikováno v:
RSC Adv.. 4:55853-55866
We have designed new potent inhibitors of thymidine monophosphate kinase of Mycobacterium tuberculosis (TMPKmt) using structure-based molecular design. Three-dimensional (3D) models of TMPKmt–inhibitor complexes were prepared by in situ modificatio