MelLec Exacerbates the Pathogenesis of Aspergillus fumigatus-Induced Allergic Inflammation in Mice

Autor: Kazuya Tone, Mark H. T. Stappers, Remi Hatinguais, Ivy M. Dambuza, Fabián Salazar, Carol Wallace, Raif Yuecel, Petruta L. Morvay, Kazuyoshi Kuwano, Janet A. Willment, Gordon D. Brown

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Environmental factors, particularly fungi, influence the pathogenesis of allergic airway inflammation, but the mechanisms underlying these effects are still unclear. Melanin is one fungal component which is thought to modulate pulmonary inflammation.

Externí odkaz: https://doaj.org/article/2dc87d39964f46f59290f2b8ae8998df

Synthesis of the fungal metabolite YWA1 and related constructs as tools to study MelLec-mediated immune response to Aspergillus infections

Autor: Chiara Zanato, Monica Piras, Christina Nikolakopoulou, Matteo Zanda, Nikki L. Sloan, Janet A. Willment, Ilaria Patruno, Gordon D. Brown

Publikováno v: Journal of organic chemistry 86 (2021): 6044–6055. doi:10.1021/acs.joc.0c02324
info:cnr-pdr/source/autori:1 Monica Piras,1 Ilaria Patruno,2-3 Christina Nikolakopoulou,2-3 Janet A Willment,4 Nikki Sloan,5 Chiara Zanato,2-3 Gordon Brown*(Corresponding Author), 1-4-6 Matteo Zanda* (Corresponding Author)/titolo:Synthesis of the fungal metabolite YWA1 and related constructs as tools to study MelLec-mediated immune response to Aspergillus infections/doi:10.1021%2Facs.joc.0c02324/rivista:Journal of organic chemistry/anno:2021/pagina_da:6044/pagina_a:6055/intervallo_pagine:6044–6055/volume:86

We describe the chemical synthesis of the fungal naphthopyrones YWA1 and fonsecin B, as well as their functionalization with an amine-spacer arm and the conjugation of the resulting molecules to three different functional tags (i.e., biotin, Oregon g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1239a0f5c0ce153c250ee8806b071d52
http://www.cnr.it/prodotto/i/454541