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Akademický článek

Novel Chrysin-De-Allyl PAC-1 Hybrid Analogues as Anticancer Compounds: Design, Synthesis, and Biological Evaluation

Autor: Buthina A. Al-Oudat, Hariteja Ramapuram, Saloni Malla, Suaad A. Audat, Noor Hussein, Jenna M. Len, Shikha Kumari, Mel F. Bedi, Charles R. Ashby, Amit K. Tiwari

Publikováno v: Molecules, Vol 25, Iss 13, p 3063 (2020)

New chrysin-De-allyl-Pac-1 hybrid analogues, tethered with variable heterocyclic systems (4a–4o), were rationally designed and synthesized. The target compounds were screened for in vitro antiproliferative efficacy in the triple-negative breast can

Externí odkaz: https://doaj.org/article/c802c7ca535f46229b0ef49cf4f9eee8

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Akademický článek

Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking

Autor: Suaad A. Audat, Nizar A. Al-Shar’i, Buthina A. Al-Oudat, Amanda Bryant-Friedrich, Mel F. Bedi, Aref L. Zayed, Qosay A. Al-Balas

Publikováno v: Molecules, Vol 25, Iss 12, p 2871 (2020)

Leukotriene B4 (LTB4) is a potent, proinflammatory lipid mediator implicated in the pathologies of an array of inflammatory diseases and cancer. The biosynthesis of LTB4 is regulated by the leukotriene A4 hydrolase (LTA4H). Compounds capable of limit

Externí odkaz: https://doaj.org/article/ed23270042104febb9ac5394ef5b2524

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Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking

Autor: Qosay Al-Balas, Amanda C. Bryant-Friedrich, Buthina A. Al-Oudat, Suaad A. Audat, Nizar A. Al-Shar’i, Mel F. Bedi, Aref Zayed

Publikováno v: Molecules, Vol 25, Iss 2871, p 2871 (2020)
Molecules
Volume 25
Issue 12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bde40f5bc89618488f2b8240b86b5c
https://www.mdpi.com/1420-3049/25/12/2871

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Design, synthesis and biological evaluation of novel glyoxalase I inhibitors possessing diazenylbenzenesulfonamide moiety as potential anticancer agents

Autor: Nizar A. Al-Shar’i, Qosay Al-Balas, Hana'a M. Jaradat, Buthina A. Al-Oudat, Mel F. Bedi, Amanda C. Bryant-Friedrich

Publikováno v: Bioorganicmedicinal chemistry. 28(16)

The enzyme glyoxalase-I (Glo-I) is an essential therapeutic target in cancer treatment. Significant efforts have been made to discover competitive inhibitors of Glo-I as potential anticancer agents. Herein, we report the synthesis of a series of diaz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18a2b84ca3225b5e1ca7a16d8d3f1cf
https://pubmed.ncbi.nlm.nih.gov/32690268

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Synthesis of damaged DNA containing the oxidative lesion 3'-oxothymidine

Autor: Taylor Gutwald, Mel F. Bedi, Amanda C. Bryant-Friedrich, Weiye Li

Publikováno v: Bioorganicmedicinal chemistry. 25(20)

Oxidative events that take place during regular oxygen metabolism can lead to the formation of organic or inorganic radicals. The interaction of these radicals with macromolecules in the organism and with DNA in particular is suspected to lead to apo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::322712207cd17f9db2f8c0f276db0f2d
https://pubmed.ncbi.nlm.nih.gov/28927804

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