Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mel C. Schroeder"'
Autor:
Teresa A. Spoon, Sheila M. Crean, Mel C. Schroeder, Amy M. Delaney, William A. Denny, James M. Hamby, Andrew M. Thompson, H. D. Hollis Showalter
Publikováno v:
Journal of Medicinal Chemistry. 48:4628-4653
7-Substituted 3-aryl-1,6-naphthyridine-2,7-diamines and related 2-ureas are inhibitors of fibroblast growth factor receptor-1 (FGFR-1) and vascular endothelial growth factor receptor-2 (VEGFR-2). 3-(3,5-Dimethoxyphenyl) and 3-phenyl analogues were pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7b8e574b8db358b15d62c303681173
https://doi.org/10.1021/jm0500931
https://doi.org/10.1021/jm0500931
Autor:
Jean Veith, Barbara W. Henderson, Mel C. Schroeder, Adam B. Sumlin, Denise Driscoll, Paula J. Pera, Wayne D. Klohs, Amarnath Sharma, Sylvester Klutchko, Charles J. Dimitroff, Randall W. Steinkampf, Ralph J. Bernacki, Thomas J. Dougherty
Publikováno v:
Investigational New Drugs. 17:121-135
Angiogenesis, the formation of new blood vessels from an existing vasculature, is requisite for tumor growth. It entails intercellular coordination of endothelial and tumor cells through angiogenic growth factor signaling. Interruption of these event
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d846089d48c21d015fa42fc8351a5790
https://doi.org/10.1023/a:1006367032156
https://doi.org/10.1023/a:1006367032156
Autor:
Wayne D. Klohs, James Marino Hamby, Alan J. Kraker, David W. Fry, Cindy Shen, Aneesa Amar, Robert L. Panek, Gina H. Lu, Barvian Mark Robert, Connolly Cleo, Mel C. Schroeder, Annette Marian Doherty
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2415-2420
The inhibition of tyrosine kinase-mediated signal transduction pathways represents a therapeutic approach to the intervention of proliferative diseases such as cancer, atherosclerosis, and restenosis. A novel series of pyrido[2,3-d]pyrimidine inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9bb0b58520cb32a1bc8a539ccb0b14e
https://doi.org/10.1016/s0960-894x(97)00445-9
https://doi.org/10.1016/s0960-894x(97)00445-9
Autor:
Donna Reynolds Cody, Mel C. Schroeder, Sheila Dewitt, Charles J. Stankovic, John S. Kiely, Michael R. Pavia
Publikováno v:
Proceedings of the National Academy of Sciences. 90:6909-6913
Solid-phase chemistry, organic synthesis, and an apparatus for multiple, simultaneous synthesis have been combined to generate libraries of organic compounds ("diversomers"). Arrays of compounds were synthesized over two to three steps incorporating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d395984d0dc012de6a87ebb7ee05895
https://doi.org/10.1073/pnas.90.15.6909
https://doi.org/10.1073/pnas.90.15.6909
Autor:
Edgardo Laborde, Steven VanderRoest, Mel C. Schroeder, John S. Kiely, Mark J. Suto, Themis E. Joannides, John M. Domagala, Martin A. Shapiro, Josephine A. Sesnie, Susan Elizabeth Hagen
Publikováno v:
Journal of Medicinal Chemistry. 36:871-882
A series of stereochemically pure 7-[3-(1-aminoethyl)-1-pyrrolidinyl]-1, 4-dihydro-4-oxoquinoline and 1,8-naphthyridine-3-carboxylic acids, with varied substituents at the 1-, 5-, and 8-positions, were synthesized to study the effects of the 7-[3-(1-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9465083060745813bc27d18171a3041b
https://doi.org/10.1021/jm00059a012
https://doi.org/10.1021/jm00059a012
Autor:
James Marino Hamby, A L A L Et Et, Barvian Mark Robert, C. J. C. Connolly, Annette Marian Doherty, Mel C. Schroeder
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e06f252215a934e6c842bd2ad5f1355
https://doi.org/10.1002/chin.199804143
https://doi.org/10.1002/chin.199804143
Autor:
Alan J. Kraker, William L. Elliott, Sheila M. Crean, Tawny K. Dahring, Charles W. Moore, Patrick J. Grohar, Cleo J. C. Connolly, Mark R. Barvian, Gina Lu, H. D. Hollis Showalter, Patrick Vincent, Terry C. Major, and Annette M. Doherty, Robert L. Panek, Denise L. Driscoll, James M. Hamby, Mel C. Schroeder, Stacey L. Boushelle, Brian L. Batley, R. Thomas Winters
Publikováno v:
Journal of medicinal chemistry. 44(12)
In continuing our search for medicinal agents to treat proliferative diseases, we have discovered 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas as a novel class of soluble, potent, broadly active tyrosine kinase (TK) inhibitors. An efficient r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::404cfa4f92f436aa35b392e52070e9a2
https://pubmed.ncbi.nlm.nih.gov/11384237
https://pubmed.ncbi.nlm.nih.gov/11384237
Autor:
Joseph Schlessinger, James Marino Hamby, Moosa Mohammadi, Mel C. Schroeder, Gina H. Lu, Stevan R. Hubbard, Robert L. Panek, Anna V. Eliseenkova, David B. Green, Scott Froum
Publikováno v:
The EMBO journal. 17(20)
Angiogenesis, the sprouting of new blood vessels from pre-existing ones, is an essential physiological process in development, yet also plays a major role in the progression of human diseases such as diabetic retinopathy, atherosclerosis and cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d6278f0b58d33b34a6eecd8e86a188
https://pubmed.ncbi.nlm.nih.gov/9774334
https://pubmed.ncbi.nlm.nih.gov/9774334
Autor:
Joan A. Keiser, Tawny K. Dahring, Mel C. Schroeder, and Hussein Hallak, David W. Fry, H. D. Hollis Showalter, James Marino Hamby, Aneesa Amar, Alan J. Kraker, Gina H. Lu, R. Thomas Winters, C. J. C. Connolly, Cindy Shen, James M. Nelson, Annette Marian Doherty, Michael J. Ryan, T C Major, Laura A. Bradford, Veronika Slintak, Bronislawa Olsewski, Robert L. Panek
Publikováno v:
Journal of medicinal chemistry. 40(15)
Screening of a compound library for inhibitors of the fibroblast growth factor (FGFr) and platelet-derived growth factor (PDGFr) receptor tyrosine kinases led to the development of a novel series of ATP competitive pyrido[2,3-d]pyrimidine tyrosine ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb64308444b49cda43326bd277026e85
https://pubmed.ncbi.nlm.nih.gov/9240345
https://pubmed.ncbi.nlm.nih.gov/9240345
Autor:
Mohammadi, Moosa, Froum, Scott, Hamby, James M., Mel C. Schroeder, Panek, Robert L., Lu, Gina H., Eliseenkova, Anna V., Green, David, Schlessinger, Joseph, Hubbard, Stevan R.
Publikováno v:
EMBO Journal; 10/15/98, Vol. 17 Issue 20, p5896-5904, 9p