Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Mel B Feany"'
Publikováno v:
PLoS Genetics, Vol 17, Iss 2, p e1009359 (2021)
Vesicular trafficking defects, particularly those in the autophagolysosomal system, have been strongly implicated in the pathogenesis of Parkinson's disease and related α-synucleinopathies. However, mechanisms mediating dysfunction of membrane traff
Externí odkaz:
https://doaj.org/article/0f29ea23be93452e8118a8a2f5e748bf
Publikováno v:
PLoS Biology, Vol 16, Iss 12, p e2006265 (2018)
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson disease. Genetics and neuropathology link Parkinson disease with the microtubule-binding protein tau, but the mechanism of action of LRRK2 mutations and
Externí odkaz:
https://doaj.org/article/335eb359752c4c3682dc9a812a997ae6
Autor:
Carin A Loewen, Mel B Feany
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
The unfolded protein response is a critical system by which the cell handles excess misfolded protein in the secretory pathway. The role of the system in modulating the effects of aggregation prone cytosolic proteins has received less attention. We u
Externí odkaz:
https://doaj.org/article/23961958d69a414db526747d032d1625
Autor:
Vikram Khurana, Ilan Elson-Schwab, Tudor A Fulga, Katherine A Sharp, Carin A Loewen, Erin Mulkearns, Jaana Tyynelä, Clemens R Scherzer, Mel B Feany
Publikováno v:
PLoS Genetics, Vol 6, Iss 7, p e1001026 (2010)
Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal connection to Alzheimer's dise
Externí odkaz:
https://doaj.org/article/aac121ca1623427eb049dd57cbdfc71c
Autor:
Vanitha Nithianandam, Hassan Bukhari, Matthew J. Leventhal, Rachel A. Battaglia, Xianjun Dong, Ernest Fraenkel, Mel B. Feany
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Aβ peptides derived from the amyloid precursor protein (APP) have been strongly implicated in the pathogenesis of Alzheimer’s disease. However, the normal function of APP and the importance of that role in neurodegenerative disease is les
Externí odkaz:
https://doaj.org/article/189e34beec2d4e72b27b05854a87e2ee
Autor:
Matthew Torre, Hassan Bukhari, Vanitha Nithianandam, Camila A. Zanella, Douglas A. Mata, Mel B. Feany
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Chemotherapy-related cognitive impairment (CRCI) is a common adverse effect of treatment and is characterized by deficits involving multiple cognitive domains including memory. Despite the significant morbidity of CRCI and the expected incre
Externí odkaz:
https://doaj.org/article/0d9d647c62cb4119a73d5ce28b529c5c
Autor:
Xianjun Dong, Yunfei Bai, Zhixiang Liao, David Gritsch, Xiaoli Liu, Tao Wang, Rebeca Borges-Monroy, Alyssa Ehrlich, Geidy E. Serrano, Mel B. Feany, Thomas G. Beach, Clemens R. Scherzer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Little is known about circular RNAs (circRNAs) in specific brain cells and human neuropsychiatric disease. Here, we systematically identify over 11,039 circRNAs expressed in vulnerable dopamine and pyramidal neurons laser-captured from 190 h
Externí odkaz:
https://doaj.org/article/6936cd80770c472cbff0981a1b79ac6b
Publikováno v:
Cells, Vol 12, Iss 7, p 978 (2023)
Alexander disease (AxD) is caused by mutations in the gene for glial fibrillary acidic protein (GFAP), an intermediate filament expressed by astrocytes in the central nervous system. AxD-associated mutations cause GFAP aggregation and astrogliosis, a
Externí odkaz:
https://doaj.org/article/73cf2e06e61d4e96bc33ab64935f77de
Autor:
Rishab Gupta, Vihar Patel, Scott M. McGinnis, David Silbersweig, Michael B. Miller, Mel B. Feany, Kirk Daffner, Seth A. Gale
Publikováno v:
The Journal of Neuropsychiatry and Clinical Neurosciences. 35:4-11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c10c7537ed7878a3c5b9a64940fd0011
https://doi.org/10.1176/appi.neuropsych.20220151
https://doi.org/10.1176/appi.neuropsych.20220151
Publikováno v:
Movement Disorders. 38:244-255
Parkinson's disease (PD) is characterized by α-synuclein aggregation and loss of dopamine neurons. Risk of PD arises due to a combination of genetic and environmental factors, which may interact, termed gene-environment (G×E) interactions. An inver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812798f68c40e06dc87f3601188b3de3
https://doi.org/10.1002/mds.29283
https://doi.org/10.1002/mds.29283