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Topologically Associating Domain Boundaries are Commonly Required for Normal Genome Function

Autor: Rajderkar, Sudha, Barozzi, Iros, Zhu, Yiwen, Hu, Rong, Zhang, Yanxiao, Li, Bin, Fukuda-Yuzawa, Yoko, Kelman, Guy, Akeza, Adyam, Blow, Matthew, Pham, Quan, Harrington, Anne, Godoy, Janeth, Meky, Eman, von Maydell, Kianna, Novak, Catherine, Plajzer-Frick, Ingrid, Afzal, Veena, Tran, Stella, Talkowski, Michael, Kent Lloyd, KC, Ren, Bing, Dickel, Diane, Visel, Axel, Pennacchio, Len

Summary Topologically associating domain (TAD) boundaries are thought to partition the genome into distinct regulatory territories. Anecdotal evidence suggests that their disruption may interfere with normal gene expression and cause disease phenotyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cf02900ad9226c6736ed700cf8b012e0
https://escholarship.org/uc/item/9cg336t7

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Characterization of Mammalian In Vivo Enhancers Using Mouse Transgenesis and CRISPR Genome Editing.

Autor: Osterwalder M; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Tran S; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Hunter RD; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Meky EM; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., von Maydell K; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Harrington AN; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Godoy J; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Novak CS; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Plajzer-Frick I; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Zhu Y; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Akiyama JA; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Afzal V; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Kvon EZ; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA., Pennacchio LA; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. LAPennacchio@lbl.gov.; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. LAPennacchio@lbl.gov.; Comparative Biochemistry Program, University of California, Berkeley, CA, USA. LAPennacchio@lbl.gov., Dickel DE; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. DEDickel@lbl.gov., Visel A; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. AVisel@lbl.gov.; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. AVisel@lbl.gov.; School of Natural Sciences, University of California, Merced, Merced, CA, USA. AVisel@lbl.gov.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2403, pp. 147-186.