Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mekdes, Debela"'
Autor:
Mekdes Debela, Viktor Magdolen, Wolfgang Skala, Brigitta Elsässer, Eric L. Schneider, Charles S. Craik, Martin L. Biniossek, Oliver Schilling, Wolfram Bode, Hans Brandstetter, Peter Goettig
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Human KLK8/neuropsin, a kallikrein-related serine peptidase, is mostly expressed in skin and the hippocampus regions of the brain, where it regulates memory formation by synaptic remodeling. Substrate profiles of recombinant KLK8 were analyz
Externí odkaz:
https://doaj.org/article/c16e2c7087564dea9f129dcd30f35722
Autor:
Pin-Chia Hsu, Gisela Storz, Ben F. Luisi, Mona W. Orr, Syma Khalid, Firdaus Samsudin, Leana M. Ramos, Catherine E. Newman, Arthur Neuberger, Andrzej Szewczak-Harris, Dijun Du, Mekdes Debela
Publikováno v:
Structure
Structure(London, England:1993)
Structure(London, England:1993)
Summary The small protein AcrZ in Escherichia coli interacts with the transmembrane portion of the multidrug efflux pump AcrB and increases resistance of the bacterium to a subset of the antibiotic substrates of that transporter. It is not clear how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7fb13e59de21a99e60c03a7386daf3
https://eprints.soton.ac.uk/441826/
https://eprints.soton.ac.uk/441826/
Publikováno v:
Biological chemistry
Although kallikrein-related peptidase 10 (KLK10) is expressed in a variety of human tissues and body fluids, knowledge of its physiological functions is fragmentary. Similarly, the pathophysiology of KLK10 in cancer is not well understood. In some ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::02eb2b1fc5548d0037f460e31250345f
https://pubmed.ncbi.nlm.nih.gov/27611765
https://pubmed.ncbi.nlm.nih.gov/27611765
Autor:
Viktor Magdolen, Valérie Gratio, Mekdes Debela, Dalila Darmoul, Josefine Maier, G. Duke Virca, Nathalie Beaufort, Nicolai Grebenchtchikov, Lina Seiz
Publikováno v:
The American Journal of Pathology. 176:1452-1461
Certain serine proteases are considered to be signaling molecules that act through protease-activated receptors (PARs). Our recent studies have implicated PAR1 and PAR4 (thrombin receptors) and PAR2 (trypsin receptor) in human colon cancer growth. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76585fe62974b1ec5a165a2cf0be6faf
https://doi.org/10.2353/ajpath.2010.090523
https://doi.org/10.2353/ajpath.2010.090523
Autor:
Robert Huber, Mekdes Debela, Peter Goettig, Wolfram Bode, Viktor Magdolen, Norman M. Schechter
Publikováno v:
Journal of Molecular Biology. 373:1017-1031
Human kallikrein 5 (hK5) is a member of the tissue kallikrein family of serine peptidases. It has trypsin-like substrate specificity, is inhibited by metal ions, and is abundantly expressed in human skin, where it is believed to play a central role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7256271fa46fe376006ed455d37da997
https://doi.org/10.1016/j.jmb.2007.08.042
https://doi.org/10.1016/j.jmb.2007.08.042
Autor:
Peter Goettig, Norman Schechter, Friedrich Lottspeich, Wolfram Bode, Charles S. Craik, Mekdes Debela, Martina Valachova, Youngchool Choe, Viktor Magdolen
Publikováno v:
Journal of Biological Chemistry. 281:25678-25688
Human tissue kallikreins (hKs) form a family of 15 closely related (chymo)trypsin-like serine proteinases. These tissue kallikreins are expressed in a wide range of tissues including the central nervous system, the salivary gland, and endocrine-regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056618bda42859b43903f66f049dc70b
https://doi.org/10.1074/jbc.m602372200
https://doi.org/10.1074/jbc.m602372200
Autor:
Daniel T. Utzschneider, Charles S. Craik, Wolfgang Skala, Peter Goettig, Hans Brandstetter, Mekdes Debela, Shihui Guo, Viktor Magdolen
Publikováno v:
The Journal of Biological Chemistry
JOURNAL OF BIOLOGICAL CHEMISTRY
JOURNAL OF BIOLOGICAL CHEMISTRY
Background: Serine proteases KLK2 and KLK3 clear the way for spermatozoa before impregnation. Results: Enzymatic assays and structures of KLK2 elucidate its catalytic action, especially when compared with conformations of similar proteases. Conclusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415b7310ab15a813cd7df6d16a0c1384
https://pubmed.ncbi.nlm.nih.gov/25326387
https://pubmed.ncbi.nlm.nih.gov/25326387
Autor:
Karolina Plaza, Nathalie Beaufort, Amelie Schwarz, Manfred Schmitt, Viktor Magdolen, Julia M Burkhart, Sabine Creutzburg, Daniel T. Utzschneider, Mekdes Debela, Christian Ries
Publikováno v:
Biological chemistry. 391(5)
Human kallikrein-related peptidases (KLKs) are 15 homologous serine proteases involved in several (patho)physiological processes, including cancer. Secreted as precursors, they are activated upon proteolytic release of a short pro-peptide. We searche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9815e70428d626e46ecedad4be59fd1
https://pubmed.ncbi.nlm.nih.gov/20302517
https://pubmed.ncbi.nlm.nih.gov/20302517
Autor:
Michael Blaber, Peter Goettig, Hyesook Yoon, Mekdes Debela, Isobel A. Scarisbrick, Sachiko I. Blaber
We previously reported the activation profiles of the human kallikrein-related peptidases (KLKs) as determined from a KLK pro-peptide fusion-protein system. That report described the activity profiles of 12 of the 15 mature KLKs versus the 15 differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e330f12106c5634d27080d4870099a
https://europepmc.org/articles/PMC2838389/
https://europepmc.org/articles/PMC2838389/