Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Meizhong, Xu"'
Autor:
Peggy A. Scherle, Robert C. Newton, Wenqing Yao, Jincong Zhuo, Meizhong Xu, Chunhong He, Sharon Diamond, Jason Boer, Yu Li, Richard Wynn, Elham Behshad, Jordan S. Fridman, Leslie M. Hall, Holly K. Koblish, Cindy Marando, Gengjie Yang, Qian Wang, Xiangdong Liu
PDF file - 91K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e2ac65557a6da0e73230a1e910ea93
https://doi.org/10.1158/1078-0432.22443831.v1
https://doi.org/10.1158/1078-0432.22443831.v1
Autor:
Peggy A. Scherle, Robert C. Newton, Wenqing Yao, Jincong Zhuo, Meizhong Xu, Chunhong He, Sharon Diamond, Jason Boer, Yu Li, Richard Wynn, Elham Behshad, Jordan S. Fridman, Leslie M. Hall, Holly K. Koblish, Cindy Marando, Gengjie Yang, Qian Wang, Xiangdong Liu
PDF file - 94K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38dc9ab0796303e073ea0830c1554ad1
https://doi.org/10.1158/1078-0432.22443834
https://doi.org/10.1158/1078-0432.22443834
Autor:
Peggy A. Scherle, Robert C. Newton, Wenqing Yao, Jincong Zhuo, Meizhong Xu, Chunhong He, Sharon Diamond, Jason Boer, Yu Li, Richard Wynn, Elham Behshad, Jordan S. Fridman, Leslie M. Hall, Holly K. Koblish, Cindy Marando, Gengjie Yang, Qian Wang, Xiangdong Liu
PDF file - 66K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a72bf8abaf13e94800645d9e3c5eb8d
https://doi.org/10.1158/1078-0432.22443828
https://doi.org/10.1158/1078-0432.22443828
Autor:
Colin, Zhang, Meizhong, Xu, Chunhong, He, Jincong, Zhuo, David M, Burns, Ding-Quan, Qian, Qiyan, Lin, Yun-Long, Li, Lihua, Chen, Eric, Shi, Costas, Agrios, Linkai, Weng, Vaqar, Sharief, Ravi, Jalluri, Yanlong, Li, Peggy, Scherle, Sharon, Diamond, Deborah, Hunter, Maryanne, Covington, Cindy, Marando, Richard, Wynn, Kamna, Katiyar, Nancy, Contel, Kris, Vaddi, Swamy, Yeleswaram, Gregory, Hollis, Reid, Huber, Steve, Friedman, Brian, Metcalf, Wenqing, Yao
Publikováno v:
SSRN Electronic Journal.
11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) has been identified as the primary enzyme responsible for the activation of hepatic cortisone to cortisol in specific peripheral tissues resulting in the concomitant antagonism of insulin action within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3692552a04b6f880ed62ecd30b202590
https://doi.org/10.2139/ssrn.4056120
https://doi.org/10.2139/ssrn.4056120
Autor:
Costas Agrios, Brian Metcalf, Lingkai Weng, Ding-Quan Qian, David M. Burns, Yun-Long Li, Jincong Zhuo, Colin Zhang, Meizhong Xu, Qiyan Lin, Chunhong He, Eric Shi, Wenqing Yao
Publikováno v:
Synlett. 2007:0460-0464
An efficient asymmetric synthesis of conformationally constrained (2S,3S)-piperidinedicarboxylic acid derivatives starting from L-aspartic acid β-tert-butyl ester and 3-chloro-2-(chloromethyl)-1-propene is described. The key steps involve N-alkylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ecff296c2c3f79070f2e572b0dd7cac
https://doi.org/10.1055/s-2007-968029
https://doi.org/10.1055/s-2007-968029
Autor:
Lingkai Weng, Qiyan Lin, Ravi Kumar Jalluri, Eric Shi, Maryanne Covington, Ding-Quan Qian, Peggy Scherle, Timothy Burn, Jordan S. Fridman, Kamna Katiyar, Costas Agrios, Max Pan, Kris Vaddi, Changnian Liu, Zelda Wasserman, Nancy Taylor, Eian Caulder, Wenqing Yao, Robert C. Newton, Gregory Hollis, Steven Friedman, Yanlong Li, Bing-Bing Zhou, Yun-Long Li, Michael J. Bower, Chunhong He, Xiangdong Liu, Colin Zhang, Jincong Zhuo, Meizhong Xu, Swamy Yeleswaram, David M. Burns, Cindy A. Marando, Richard Wynn, Brian Metcalf
Publikováno v:
Journal of Medicinal Chemistry. 50:603-606
The design, synthesis, evaluation, and identification of a novel class of (6S,7S)-N-hydroxy-6-carboxamide-5-azaspiro[2.5]octane-7-carboxamides as the first potent and selective inhibitors of human epidermal growth factor receptor-2 (HER-2) sheddase i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baef3a8ed08b12286d84bda86fa256d1
https://doi.org/10.1021/jm061344o
https://doi.org/10.1021/jm061344o
Autor:
Yun-Long Li, Brian Metcalf, Richard Wynn, Mark Stow, Yanlong Li, Qiyan Lin, Kamna Katiyar, Eric Shi, Costas Agrios, Vaqar Sharief, Lingkai Weng, Reid Huber, Steven M. Friedman, Peggy A. Scherle, Timothy Burn, Xiangdong Liu, Meizhong Xu, Gregory F. Hollis, Colin Zhang, David M. Burns, Dawn Ellis, Robert Newton, Phillip Liu, Cindy Marando, Maryanne B. Covington, Chunhong He, M.C. Hillman, Gengjie Yang, Jincong Zhuo, Mark Rupar, Ding-Quan Qian, Wenqing Yao, Kenneth Abremski, Jodi D. Bradley
Publikováno v:
Cancer Biology & Therapy. 5:657-664
Overexpression and activating mutations of ErbB family members have been implicated in the development and progression of a variety of tumor types. Cleavage of the HER2 receptor by an as yet unidentified ectodomain sheddase has been shown to liberate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c435ae0c30ea356f73c04aba227fa78d
https://doi.org/10.4161/cbt.5.6.2708
https://doi.org/10.4161/cbt.5.6.2708
Autor:
Carl P. Decicco, Meizhong Xu, Rui-Qin Liu, Yvonne C. Lo, Percy H. Carter, Lorin A. Thompson, James M. Trzaskos, Gengjie Yang, Andrew J. Tebben, J. Gerry Everlof, Paul Strzemienski, Peggy A. Scherle, Gregory D. Brown, Matthew E. Voss
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:533-538
Based on the realization that N-alkyl 5-arylidene-2-thioxo-1,3-thiazolidin-4-ones are tumor necrosis factor-alpha antagonists, we discovered two additional classes of antagonists: 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones (via rational desig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18edecff53bec99dad04afa5713d30ef
https://doi.org/10.1016/s0960-894x(02)00941-1
https://doi.org/10.1016/s0960-894x(02)00941-1
Autor:
Meizhong Xu, Cindy Marando, Leslie Hall, Richard Wynn, Wenqing Yao, Chunhong He, Robert Newton, Jordan S. Fridman, Xiangdong Liu, Yu Li, Jason Boer, Peggy A. Scherle, Gengjie Yang, Sharon Diamond, Elham Behshad, Qian Wang, Holly Koblish, Jincong Zhuo
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 17(22)
Purpose: The c-MET receptor tyrosine kinase plays important roles in the formation, progression, and dissemination of human cancer and presents an attractive therapeutic target. This study describes the preclinical characterization of INCB28060, a no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eccbcddfd14fc68fdcfeaaec345a8f94
https://pubmed.ncbi.nlm.nih.gov/21918175
https://pubmed.ncbi.nlm.nih.gov/21918175
Autor:
Yun-Long Li, Wenqing Yao, Eric Shi, Jordan S. Fridman, Maryanne Covington, Peggy Scherle, Ding-Quan Qian, Jincong Zhuo, Kamna Katiyar, Colin Zhang, Meizhong Xu, David M. Burns, Cindy A. Marando, Richard Wynn, Steve Friedman, Yanlong Li, Chunhong He, Brian Metcalf
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(13)
A serendipitous discovery that the metalloprotease binding profile of a novel class of 2-carboxamide-3-hydroxamic acid piperidines could be significantly attenuated by the modification of the unexplored P1 substituent enabled the design and synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed15c6394336e639e5722ae7c33a8f8
https://pubmed.ncbi.nlm.nih.gov/19457660
https://pubmed.ncbi.nlm.nih.gov/19457660