Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Meizhen Zheng"'
Autor:
Rui Chen, Xinyao Shi, Xiangrui Yao, Tong Gao, Guangyu Huang, Duo Ning, Zemin Cao, Youxin Xu, Weizheng Liang, Simon Zhongyuan Tian, Qionghua Zhu, Liang Fang, Meizhen Zheng, Yuhui Hu, Huanhuan Cui, Wei Chen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract CRISPR/Cas-based transcriptional activators can be enhanced by intrinsically disordered regions (IDRs). However, the underlying mechanisms are still debatable. Here, we examine 12 well-known IDRs by fusing them to the dCas9-VP64 activator, o
Externí odkaz:
https://doaj.org/article/ceef07aaa4ad422491da45a1b81f56bd
Autor:
Simon Zhongyuan Tian, Pengfei Yin, Kai Jing, Yang Yang, Yewen Xu, Guangyu Huang, Duo Ning, Melissa J. Fullwood, Meizhen Zheng
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Chromatin structural domains, or topologically associated domains (TADs), are a general organizing principle in chromatin biology. RNA polymerase II (RNAPII) mediates multiple chromatin interactive loops, tethering together as RNAPII-associated chrom
Externí odkaz:
https://doaj.org/article/dc9b36bedb3f46beb7c5ce9856ed3ac6
Autor:
Ping Wang, Zhonghui Tang, Byoungkoo Lee, Jacqueline Jufen Zhu, Liuyang Cai, Przemyslaw Szalaj, Simon Zhongyuan Tian, Meizhen Zheng, Dariusz Plewczynski, Xiaoan Ruan, Edison T. Liu, Chia-Lin Wei, Yijun Ruan
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-21 (2020)
Abstract Background Acute promyeloid leukemia (APL) is characterized by the oncogenic fusion protein PML-RARα, a major etiological agent in APL. However, the molecular mechanisms underlying the role of PML-RARα in leukemogenesis remain largely unkn
Externí odkaz:
https://doaj.org/article/ca1f2e55568d425387ee866b9625748d
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract The single-molecule multiplex chromatin interaction data are generated by emerging 3D genome mapping technologies such as GAM, SPRITE, and ChIA-Drop. These datasets provide insights into high-dimensional chromatin organization, yet introduce
Externí odkaz:
https://doaj.org/article/21e865a9053d4fe8949b8fb13f9ca33f
Autor:
Tao Chen, Yu-Xin Lin, Yan Zha, Ying Sun, Jinxiu Tian, Zhiying Yang, Shan-Wen Lin, Fuxun Yu, Zi-Sheng Chen, Bo-Hua Kuang, Jin-Ju Lei, Ying-jie Nie, Yonghao Xu, Dong-Bo Tian, Ying-Zi Li, Bin Yang, Qiang Xu, Li Yang, Nanshan Zhong, Meizhen Zheng, Yimin Li, Jincun Zhao, Xiang-Yan Zhang, Lin Feng
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Overproduction of cytokine interleukin-6 (IL-6) is a hallmark of severe COVID-19 and is believed to play a critical role in exacerbating the excessive inflammatory response. Polymorphisms in IL-6
Externí odkaz:
https://doaj.org/article/97fc514b23474874a78ba95c85b85b89
Autor:
Yuankai Shi, Junling Li, Shucai Zhang, Mengzhao Wang, Shujun Yang, Ning Li, Gang Wu, Wei Liu, Guoqing Liao, Kaican Cai, Liang'an Chen, Meizhen Zheng, Ping Yu, Xiuwen Wang, Yunpeng Liu, Qisen Guo, Ligong Nie, Jiwei Liu, Xiaohong Han
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143515 (2015)
Epidermal growth factor receptor (EGFR) mutations are the strongest response predictors to EGFR tyrosine kinase inhibitors (TKI) therapy, but knowledge of the EGFR mutation frequency on lung adenocarcinoma is still limited to retrospective studies. T
Externí odkaz:
https://doaj.org/article/baaa4a1dda684e5684b982d8c960de64
Publikováno v:
The Scientific World Journal, Vol 2014 (2014)
A copolymer of acrylamide (AM) with acryloyloxyethyl trimethyl ammonium chloride (DAC) as the cationic monomer was synthesized under the irradiation of high-pressure mercury lamp with 2,2-azobis(2-amidinopropane) dihydrochloride (V-50) as the photoin
Externí odkaz:
https://doaj.org/article/00cd5bc1ba384f428674f37c355b5a64
Autor:
Simon Zhongyuan Tian, Guoliang Li, Duo Ning, Kai Jing, Yewen Xu, Yang Yang, Melissa J Fullwood, Pengfei Yin, Guangyu Huang, Dariusz Plewczynski, Jixian Zhai, Ziwei Dai, Wei Chen, Meizhen Zheng
Publikováno v:
Briefings in bioinformatics. 23(6)
The emerging ligation-free three-dimensional (3D) genome mapping technologies can identify multiplex chromatin interactions with single-molecule precision. These technologies not only offer new insight into high-dimensional chromatin organization and
Autor:
Zhuowen Li, Yanping Long, Yiming Yu, Fei Zhang, Hong Zhang, Zhijian Liu, Jinbu Jia, Weipeng Mo, Simon Zhongyuan Tian, Meizhen Zheng, Jixian Zhai
In the past decade, genome-wide characterization of the three-dimensional chromatin structure in plants using high-throughput methods has greatly advanced our knowledge in plant genome architecture (Liu and Weigel, 2015; Ouyang et al., 2020). However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5496b982f0f5541adfff4c1ff16558
https://doi.org/10.1101/2022.01.20.477161
https://doi.org/10.1101/2022.01.20.477161
Autor:
Ying Sun, Yimin Li, Li Yang, Qiang Xu, Yan Zha, Fuxun Yu, Jinxiu Tian, Lin Feng, Bin Yang, Nanshan Zhong, Ying-Zi Li, Bo-Hua Kuang, Yingjie Nie, Meizhen Zheng, Zhiying Yang, Yu-Xin Lin, Yonghao Xu, Shanwen Lin, Jin-Ju Lei, Jincun Zhao, Zhang Xiangyan, Zisheng Chen, Tao Chen, Dong-Bo Tian
Publikováno v:
mBio
mBio, Vol 12, Iss 5 (2021)
mBio, Vol 12, Iss 5 (2021)
Interleukin6 (IL-6) is a key driver of hyperinflammation in COVID-19, and its level strongly correlates with disease progression. To investigate whether variability in COVID-19 severity partially results from differential IL-6 expression, functional