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Akademický článek

Enhanced Cytotoxic Effects of Arenite in Combination with Active Bufadienolide Compounds against Human Glioblastoma Cell Line U-87

Autor: Bo Yuan, Jingmei Li, Shin-Ich Miyashita, Hidetomo Kikuchi, Meiyan Xuan, Hirokazu Matsuzaki, Naohiro Iwata, Shinya Kamiuchi, Katsuyoshi Sunaga, Takeshi Sakamoto, Yasuhide Hibino, Mari Okazaki

Publikováno v: Molecules, Vol 27, Iss 19, p 6577 (2022)

The cytotoxicity of a trivalent arsenic derivative (arsenite, AsIII) combined with arenobufagin or gamabufotalin was evaluated in human U-87 glioblastoma cells. Synergistic cytotoxicity with upregulated intracellular arsenic levels was observed, when

Externí odkaz: https://doaj.org/article/4d4495d3f7594f838dd141bd8cc2b1c7

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Involvement of the Restoration of Cerebral Blood Flow and Maintenance of eNOS Expression in the Prophylactic Protective Effect of the Novel Ferulic Acid Derivative FAD012 against Ischemia/Reperfusion Injuries in Rats

Autor: Okazaki, Takashi Asano, Meiyan Xuan, Naohiro Iwata, Jun Takayama, Kousuke Hayashi, Yosuke Kato, Toshiya Aoyama, Hiroshi Sugo, Hirokazu Matsuzaki, Bo Yuan, Shinya Kamiuchi, Yasuhide Hibino, Takeshi Sakamoto, Mari

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9663

Tissue plasminogen activator, aiming to restore cerebral blood flow (CBF), has been used for acute ischemic strokes in clinics; however, its narrow therapeutic time window remains a serious concern. To develop novel prophylactic drugs to alleviate ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::dad2461219aa816b72221e7def10e04d

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A study of enantioselective syntheses by Sharpless asymmetric oxidation for aryl sulfoxides containing oxygen groups at the ortho position

Autor: Meiyan Xuan, Jun Takayama, Hiroshi Miyamae, Misa Tomoda, Takanori Takei, Takeshi Sakamoto

Publikováno v: Journal of Chemical Sciences. 133

While ortho-alkoxy aryl sulfoxides including various substituents were synthesized by Sharpless asymmetric oxidation reaction, we optimized the reaction conditions and screened better combination of starting materials to obtain high enantioselectivit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45dbf13dab7ad2a9416cf47be9dcb049
https://doi.org/10.1007/s12039-021-01887-5

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Characterization of 6-bromoferulic acid as a novel common-use matrix for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Autor: Yasushi Sakamoto, Yosuke Kato, Yuko Suzuki, Narumi Hirosawa, Ayako Hoshi, Meiyan Xuan, Jun Takayama, Takeshi Moriguchi, Takeshi Sakamoto, Mari Okazaki

Publikováno v: Rapid communications in mass spectrometry : RCMREFERENCES. 34(7)

Rationale Ferulic acid (FA) is a standard matrix used for analyzing proteins. In this study, the ability of a halogenated FA to serve as an effective MALDI matrix was investigated. Various halogenated FAs were synthesized, and the characteristics and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75793ee954d3dc4e675d4fb5a0a28e4
https://pubmed.ncbi.nlm.nih.gov/31659809

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