Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Meixiao, Long"'
Autor:
Jessica Nunes, Rakeb Tafesse, Charlene Mao, Matthew Purcell, Xiaokui Mo, Liwen Zhang, Meixiao Long, Matthew G. Cyr, Christoph Rader, Natarajan Muthusamy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Siglec-6 is a lectin receptor with restricted expression in the placenta, mast cells and memory B-cells. Although Siglec-6 is expressed in patients with chronic lymphocytic leukemia (CLL), its pathophysiological role has not been elucidated.
Externí odkaz:
https://doaj.org/article/77c2a2030f1740c4a3efc4a6ce473897
Autor:
Po-Lan Su, Karthik Chakravarthy, Naoki Furuya, Jeremy Brownstein, Jianhua Yu, Meixiao Long, David Carbone, Zihai Li, Kai He
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-5 (2024)
Abstract DLL3 acts as an inhibitory ligand that downregulates Notch signaling and is upregulated by ASCL1, a transcription factor prevalent in the small-cell lung cancer (SCLC) subtype SCLC-A. Currently, the therapeutic strategies targeting DLL3 are
Externí odkaz:
https://doaj.org/article/d10fc426c38f4600bcf76fa725a89e1b
Autor:
Zhongyi Hu, Junzhi Zhou, Junjie Jiang, Jiao Yuan, Youyou Zhang, Xuepeng Wei, Nicki Loo, Yueying Wang, Yutian Pan, Tianli Zhang, Xiaomin Zhong, Meixiao Long, Kathleen T. Montone, Janos L. Tanyi, Yi Fan, Tian-Li Wang, Ie-Ming Shih, Xiaowen Hu, Lin Zhang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Targeting histone acetylation modulators (HAMPs) is a promising avenue of drug discovery in cancer research. Here, the authors integrate multi-dimensional genomic profiles to systematically investigate recurrent genomic alterations in HAMPs, identify
Externí odkaz:
https://doaj.org/article/ac4b69723bc14d03a184d8c6e51e4ce5
Autor:
Weiwei Shan, Jiao Yuan, Zhongyi Hu, Junjie Jiang, Yueying Wang, Nicki Loo, Lingling Fan, Zhaoqing Tang, Tianli Zhang, Mu Xu, Yutian Pan, Jiaqi Lu, Meixiao Long, Janos L. Tanyi, Kathleen T. Montone, Yi Fan, Xiaowen Hu, Youyou Zhang, Lin Zhang
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107884- (2020)
Summary: Recurrent copy-number alterations, mutations, and transcript fusions of the genes encoding CDKs/cyclins are characterized in >10,000 tumors. Genomic alterations of CDKs/cyclins are dominantly driven by copy number aberrations. In contrast to
Externí odkaz:
https://doaj.org/article/df0a1c45bad143fc86c58308236cbcb2
Autor:
Nyla A. Heerema, Natarajan Muthusamy, Qiuhong Zhao, Amy S. Ruppert, Heather Breidenbach, Leslie A. Andritsos, Michael R. Grever, Kami J. Maddocks, Jennifer Woyach, Farrukh Awan, Meixiao Long, Amber Gordon, Caitlin Coombes, John C. Byrd
Publikováno v:
Haematologica, Vol 106, Iss 6 (2020)
Mutations of the IGH variable region in patients with chronic lymphocytic leukemia (CLL) are associated with a favorable prognosis. Cytogenetic complexity (>3 unrelated aberrations) and translocations have been associated with an unfavorable prognosi
Externí odkaz:
https://doaj.org/article/c1f8c37f9c954bf6a8dafb620cb0ea2a
Autor:
Jiao Yuan, Kevin H Kensler, Zhongyi Hu, Youyou Zhang, Tianli Zhang, Junjie Jiang, Mu Xu, Yutian Pan, Meixiao Long, Kathleen T Montone, Janos L Tanyi, Yi Fan, Rugang Zhang, Xiaowen Hu, Timothy R Rebbeck, Lin Zhang
Publikováno v:
PLoS Genetics, Vol 16, Iss 2, p e1008641 (2020)
Men of predominantly African Ancestry (AA) have higher prostate cancer (CaP) incidence and worse survival than men of predominantly European Ancestry (EA). While socioeconomic factors drive this disparity, genomic factors may also contribute to diffe
Externí odkaz:
https://doaj.org/article/ccc34b4e3ca34c67b73edf3560795c13
Autor:
Yo-Ting Tsai, Aparna Lakshmanan, Amy Lehman, Bonnie K. Harrington, Fabienne McClanahan Lucas, Minh Tran, Ellen J. Sass, Meixiao Long, Alan D. Flechtner, Florinda Jaynes, Krista La Perle, Vincenzo Coppola, Gerard Lozanski, Natarajan Muthusamy, John C. Byrd, Michael R. Grever, David M. Lucas
Publikováno v:
Blood Advances, Vol 1, Iss 24, Pp 2147-2160 (2017)
Abstract: Mutated mitogen-activated protein kinase (MAPK) pathway components promote tumor survival, proliferation, and immune evasion in solid tumors. MAPK mutations occur in hematologic cancers as well, but their role is less clear and few models a
Externí odkaz:
https://doaj.org/article/c6e0f46b0f7340d6824ced467f0fcaeb
Autor:
Bao Zhao, Weipeng Gong, Anjun Ma, Jianwen Chen, Maria Velegraki, Hong Dong, Zihao Liu, Lingling Wang, Tamio Okimoto, Devin M. Jones, Yu L. Lei, Meixiao Long, Kenneth J. Oestreich, Qin Ma, Gang Xin, David P. Carbone, Kai He, Zihai Li, Haitao Wen
Publikováno v:
Nat Immunol
Dysfunctional CD8(+) T cells, which have defective production of antitumor effectors, represent a major mediator of immunosuppression in the tumor microenvironment. Here, we showed that SUSD2 was a negative regulator of CD8(+) T cell antitumor functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d56f6dc2957f7294b4fa369f7c83b14
https://doi.org/10.1038/s41590-022-01326-8
https://doi.org/10.1038/s41590-022-01326-8
Autor:
Krish Patel, Peter A. Riedell, Hervé Tilly, Sairah Ahmed, Jean-Marie Michot, Herve Ghesquieres, Jean Marc Schiano de Collela, Asher Chanan-Khan, Kamal Bouabdallah, Benoit Tessoulin, Sunil Iyengar, Meixiao Long, Raphael Clynes, Jitendra Kanodia, Lei Bao, Ying Ding, Jianhua Jin, William B Ainsworth, Raman Garcha, Steve Kye, Tycel J. Phillips
Publikováno v:
Blood. 140:9470-9472
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9220b6cc544321c54c0ced9ed3895eb0
https://doi.org/10.1182/blood-2022-159586
https://doi.org/10.1182/blood-2022-159586
Autor:
Janos L. Tanyi, Xiaowen Hu, Junjie Jiang, Mu Xu, Jiao Yuan, Omid Tavana, Kathleen T. Montone, Zhongyi Hu, Youyou Zhang, Yi Fan, Ho Man Chan, Lin Zhang, Meixiao Long
Publikováno v:
Cancer Res
The nuclear receptor (NR) superfamily is one of the major druggable gene families, representing targets of approximately 13.5% of approved drugs. Certain NRs, such as estrogen receptor and androgen receptor, have been well demonstrated to be function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb96c753506f1cb228e9727378ac925
https://doi.org/10.1158/0008-5472.can-20-3458
https://doi.org/10.1158/0008-5472.can-20-3458