Systematical detection of significant genes in microarray data by incorporating gene interaction relationship in biological systems.

Autor: Junwei Wang, Meiwen Jia, Liping Zhu, Zengjin Yuan, Peng Li, Chang Chang, Jian Luo, Mingyao Liu, Tieliu Shi

Publikováno v: PLoS ONE, Vol 5, Iss 10, p e13721 (2010)

Many methods, including parametric, nonparametric, and Bayesian methods, have been used for detecting differentially expressed genes based on the assumption that biological systems are linear, which ignores the nonlinear characteristics of most biolo

Externí odkaz: https://doaj.org/article/0b609ffb736541a688b7275c18fce687

Congenital heart disease risk loci identified by genome-wide association study in European patients

Autor: Harald Lahm, Julie Cleuziou, Markus Krane, I. Neb, James R. Priest, Felix Wirth, Melchior Burri, Peter Lichtner, N. Beck, Elda Dzilic, Johannes A Ziegelmüller, Thomas Meitinger, Zhong Zhang, Bertram Müller-Myhsok, Ralf Gilsbach, Peter Ewert, Olga Bondareva, Stefanie A. Doppler, Bernard Keavney, Jürgen Hörer, Heather J. Cordell, C. Abou-Ajram, Karl C. König, Nazan Puluca, Rüdiger Lange, Gertrud Eckstein, M. Dreßen, Meiwen Jia, Lutz Hein, Elisa Mastantuono

Publikováno v: J. Clin. Invest. 131:e141837 (2021)
J Clin Invest

Genetic factors undoubtedly affect the development of congenital heart disease (CHD) but still remain ill defined. We sought to identify genetic risk factors associated with CHD and to accomplish a functional analysis of SNP-carrying genes. We perfor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b92de8447f7fe27926d377db0d05287
https://doi.org/10.1172/jci141837

Genome-wide association study in European patients with congenital heart disease identifies risk loci for transposition of the great arteries and anomalies of the thoracic arteries and veins and expression of discovered candidate genes in the developing heart

Autor: I. Neb, Thomas Meitinger, F. Wirth, Ralf Gilsbach, Bernard Keavney, Priest, P. Lichtner, P. Ewert, J.A. Ziegelmüller, N. Beck, C. Abou-Ajram, Melchior Burri, Zhong Zhang, Ruediger Lange, Bertram Müller-Myhsok, Julie Cleuziou, G. Eckstein, Harald Lahm, Nazan Puluca, Stefanie A. Doppler, Olga Bondareva, Markus Krane, König Kc, Heather J. Cordell, Meiwen Jia, Lutz Hein, Elisa Mastantuono, Jürgen Hörer, M. Dreßen, E. Dzilic

RationaleGenetic factors undoubtedly contribute to the development of congenital heart disease (CHD), but still remain mostly ill-defined.ObjectiveIdentification of genetic risk factors associated with CHD and functional analysis of SNP-carrying gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f0bea85d27555a8606a18e73ed628a6
https://doi.org/10.1101/2020.06.19.161067

GWAS Analysis Reveals Previously Unknown Genomic Variants Associated with Different Subgroups of Congenital Heart Disease

Autor: Bertram Müller-Myhsok, Ruediger Lange, Harald Lahm, Stefanie A. Doppler, Thomas Meitinger, P. Lichtner, G. Eckstein, N. Beck, Meiwen Jia, M. Dreßen, Markus Krane, Julie Cleuziou, Nazan Puluca, Marcus-André Deutsch

Publikováno v: The Thoracic and Cardiovascular Surgeon. 66:S1-S110

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a229bb09c6d3ed87ba7b26ef2ecdb520
https://doi.org/10.1055/s-0038-1628044

Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-kappa B-driven inflammation and cardiovascular risk

Autor: Jens Baumert, Sonja Kunze, Meiwen Jia, Anthony S. Zannas, Elisabeth B. Binder, Bertram Müller-Myhsok, Maria Roitman, Theo Rein, Rebecca T. Emeny, Kerry J. Ressler, Tobias Wiechmann, Melanie Waldenberger, Susanne Lucae, Katri Räikkönen, Andreas Haehle, Felix Hausch, Julius C. Pape, Maik Ködel, Bekh Bradley, Jari Lahti, Janine Arloth, Simone Röh, Kathrin Hafner, Stella Iurato, Johan G. Eriksson, Christian Gieger, Karl-Heinz Ladwig, Alicia K. Smith, Silvia Martinelli, Simone Wahl, Amanda J. Drake, Tania Carrillo-Roa, Nils C. Gassen

Publikováno v: Proc. Natl. Acad. Sci. U.S.A. 166, 11370-11379 (2019)
Proceedings of the National Academy of Sciences of the United States of America
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Zannas, A S, Jia, M, Hafner, K, Baumert, J, Wiechmann, T, Pape, J C, Arloth, J, Ködel, M, Martinelli, S, Roitman, M, Röh, S, Haehle, A, Emeny, R T, Iurato, S, Carrillo-roa, T, Lahti, J, Räikkönen, K, Eriksson, J G, Drake, A J, Waldenberger, M, Wahl, S, Kunze, S, Lucae, S, Bradley, B, Gieger, C, Hausch, F, Smith, A K, Ressler, K J, Müller-myhsok, B, Ladwig, K, Rein, T, Gassen, N C & Binder, E B 2019, ' Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB–driven inflammation and cardiovascular risk ', Proceedings of the National Academy of Sciences . https://doi.org/10.1073/pnas.1816847116

Significance Diseases of the aging are the leading cause of morbidity and mortality. Elucidating the molecular mechanisms through which modifiable factors, such as psychosocial stress, confer risk for aging-related disease can have profound implicati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa4c9574c1604bcbedcb31030ddb80f
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=56105