Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Meitian Wang"'
Autor:
Filip Leonarski, Jie Nan, Zdenek Matej, Quentin Bertrand, Antonia Furrer, Ishkhan Gorgisyan, Monika Bjelčić, Michal Kepa, Hannah Glover, Viktoria Hinger, Thomas Eriksson, Aleksander Cehovin, Mikel Eguiraun, Piero Gasparotto, Aldo Mozzanica, Tobias Weinert, Ana Gonzalez, Jörg Standfuss, Meitian Wang, Thomas Ursby, Florian Dworkowski
Publikováno v:
IUCrJ, Vol 10, Iss 6, Pp 729-737 (2023)
Serial and time-resolved macromolecular crystallography are on the rise. However, beam time at X-ray free-electron lasers is limited and most third-generation synchrotron-based macromolecular crystallography beamlines do not offer the necessary infra
Externí odkaz:
https://doaj.org/article/c27c457b830e451aab9a87a194dd5a8f
Autor:
Bo Qin, Ziheng Li, Kaiming Tang, Tongyun Wang, Yubin Xie, Sylvain Aumonier, Meitian Wang, Shuofeng Yuan, Sheng Cui
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract SARS-CoV-2 nsp3 is essential for viral replication and host responses. The SARS-unique domain (SUD) of nsp3 exerts its function through binding to viral and host proteins and RNAs. Herein, we show that SARS-CoV-2 SUD is highly flexible in so
Externí odkaz:
https://doaj.org/article/75ccd2be25ba417fa81b08b7af019d98
Autor:
Kate Mary Louise Smith, Ezequiel Panepucci, Jakub Wojciech Kaminski, Sylvain Aumonier, Chia-Yiang Huang, Deniz Eris, Dominik Buntschu, Nathalie Meier, Wayne Glettig, Katherine Evelyn McAuley, Meitian Wang, May Elizabeth Sharpe, Justyna Aleksandra Wojdyla
Publikováno v:
Journal of Synchrotron Radiation, Vol 30, Iss 3, Pp 538-545 (2023)
Recent advances in automation have fostered the development of unattended data collection services at a handful of synchrotron facilities worldwide. At the Swiss Light Source, the installation of new high-throughput sample changers at all three macro
Externí odkaz:
https://doaj.org/article/c49272f676a84bcfa1d6ee239ee49510
Autor:
Maximilian Wranik, Tobias Weinert, Chavdar Slavov, Tiziana Masini, Antonia Furrer, Natacha Gaillard, Dario Gioia, Marco Ferrarotti, Daniel James, Hannah Glover, Melissa Carrillo, Demet Kekilli, Robin Stipp, Petr Skopintsev, Steffen Brünle, Tobias Mühlethaler, John Beale, Dardan Gashi, Karol Nass, Dmitry Ozerov, Philip J. M. Johnson, Claudio Cirelli, Camila Bacellar, Markus Braun, Meitian Wang, Florian Dworkowski, Chris Milne, Andrea Cavalli, Josef Wachtveitl, Michel O. Steinmetz, Jörg Standfuss
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Photopharmacology manipulates the biological activity of small molecules by light. Using an X-ray laser, the authors follow the release of the drug azo-combretastatin A4 from tubulin and the concomitant structural changes over nine orders of magnitud
Externí odkaz:
https://doaj.org/article/31ccc9f5c1c7420b8b23b5fa45bdc9ee
Jungfraujoch: hardware-accelerated data-acquisition system for kilohertz pixel-array X-ray detectors
Autor:
Filip Leonarski, Martin Brückner, Carlos Lopez-Cuenca, Aldo Mozzanica, Hans-Christian Stadler, Zdeněk Matěj, Alexandre Castellane, Bruno Mesnet, Justyna Aleksandra Wojdyla, Bernd Schmitt, Meitian Wang
Publikováno v:
Journal of Synchrotron Radiation, Vol 30, Iss 1, Pp 227-234 (2023)
The JUNGFRAU 4-megapixel (4M) charge-integrating pixel-array detector, when operated at a full 2 kHz frame rate, streams data at a rate of 17 GB s−1. To operate this detector for macromolecular crystallography beamlines, a data-acquisition system c
Externí odkaz:
https://doaj.org/article/7ae0eb7821ae464690f8d2d486462f8b
Autor:
Coilín Boland, Chia-Ying Huang, Shiva Shanker Kaki, Meitian Wang, Vincent Olieric, Martin Caffrey
Publikováno v:
Crystals, Vol 13, Iss 9, p 1402 (2023)
Both intensity and phase information are needed for structure determination by macromolecular X-ray crystallography. The diffraction experiment provides intensities. Phases must be accessed indirectly by molecular replacement, or by experimental phas
Externí odkaz:
https://doaj.org/article/5c89fea58bcb460cbe8b99cd4d1a2b11
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
SARS-CoV-2 orf9b binds to the mitochondrial outer membrane protein TOM70 and has been linked to the suppression of interferon responses. Here, the authors characterize the interactions of SARS-CoV-2 orf9b and human TOM70 biochemically, and they deter
Externí odkaz:
https://doaj.org/article/1afb5a07dd2f43a8bbd098b9cba2c45e
Autor:
Chu Zhang, Fan Yang, Justyna Aleksandra Wojdyla, Bo Qin, Wei Zhang, Min Zheng, Weijun Cao, Meitian Wang, Xiaopan Gao, Haixue Zheng, Sheng Cui
Publikováno v:
Cell Reports, Vol 40, Iss 1, Pp 111030- (2022)
Summary: The foot-and-mouth disease virus (FMDV) 2C protein shares conserved motifs with enterovirus 2Cs despite low sequence identity. Here, we determine the crystal structure of an FMDV 2C fragment to 1.83 Å resolution, which comprises an ATPase d
Externí odkaz:
https://doaj.org/article/39346d7b69924175b126b5f0bbfb7408
Autor:
Fei Gao, Ai Liu, Xing Qi, Meitian Wang, Xiao Chen, Shijun Wei, Shang Gao, Yueqing Sun, Ping Sun, Xi Li, Wenjie Sun, Jiangxia Li, Qiji Liu
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 6 (2022)
Chronic stress is one of the main risk factors for the onset of major depressive disorder. Chronic unpredictable mild stress results in reduced expression of synaptic proteins and depression-like behaviors in rodent models. However, the upstream mole
Externí odkaz:
https://doaj.org/article/58151e0993e34a1a912df04e56deb135
Autor:
Xiaopan Gao, Bo Qin, Pu Chen, Kaixiang Zhu, Pengjiao Hou, Justyna Aleksandra Wojdyla, Meitian Wang, Sheng Cui
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 237-245 (2021)
The pandemic of coronavirus disease 2019 (COVID-19) is changing the world like never before. This crisis is unlikely contained in the absence of effective therapeutics or vaccine. The papain-like protease (PLpro) of severe acute respiratory syndrome
Externí odkaz:
https://doaj.org/article/03d0c88a7d354914834792e402afc344