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pro vyhledávání: '"Meissner Robert S"'
Akademický článek
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Akademický článek
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Autor:
Perkins, James J., McQuade, Paul, Bungard, Christopher J., Diamond, Tracy L., Gantert, Liza T., Gotter, Anthony L., Hanney, Barbara, Hills, Ivory D., Hurzy, Danielle M., Joshi, Aniket, Kern, Jonathan T., Schlegel, Kelly-Ann S., Manikowski, Jesse J., Meng, Zhaoyang, O'Brien, Julie A., Roecker, Anthony J., Smith, Sean M., Uslaner, Jason M., Hostetler, Eric, Meissner, Robert S.
Publikováno v:
ACS Medicinal Chemistry Letters; 7/13/2023, Vol. 14 Issue 7, p986-992, 7p
Autor:
Bungard, Christopher J., Hartman, George D., Manikowski, Jesse J., Perkins, James J., Bai, Chang, Brandish, Philip E., Euler, Danielle H., Hershey, James C., Schmidt, Azriel, Fang, Yulin, Norcross, Ryan T., Rushmore, Tom H., Thompson, Charles D., Meissner, Robert S.
Publikováno v:
In Bioorganic & Medicinal Chemistry 15 December 2011 19(24):7374-7386
Publikováno v:
Science, 1995 Dec 01. 270(5241), 1485-1488.
Externí odkaz:
https://www.jstor.org/stable/2889013
Autor:
Kausik K. Nanda, Yang Yuan, Celina Zerbinatti, Zhongguo Chen, Yingjie Li, Rada Vanessa L, Zhenhua Wu, Jeanine E. Ballard, Meissner Robert S, D. Jonathan Bennett, Mark T. Bilodeau, Edward J. Brnardic, Jian Li, Jill W. Maxwell, Shawn J. Stachel, Michael T. Rudd, Mali Cosden, Peter Wuelfing, Marie A. Holahan, Andrew J. Cooke, Peter Szczerba, Maria S. Michener, Jun Lu, John J. Renger, Keith Wessner, Daniel J. Klein, Victor N. Uebele, Sokreine Suon, Jason M. Uslaner, Yuntae Kim, Jillian DiMuzio, Gopal Parthasarathy, Xavier Fradera
Publikováno v:
Journal of Medicinal Chemistry. 59:3489-3498
Herein, we describe the development of a functionally selective liver X receptor β (LXRβ) agonist series optimized for Emax selectivity, solubility, and physical properties to allow efficacy and safety studies in vivo. Compound 9 showed central pha
Autor:
William J. Ray, Chang Bai, Stephen E. Alves, Tara E. Cusick, Brenda L Pennypacker, Evan E. Opas, Michael J. Chisamore, Carlo J. Gambone, Damien Ferraro, David J. Bettoun, Azriel Schmidt, Hilary A. Wilkinson, Angela Scafonas, Michael A. Gentile, Osvaldo A. Flores, Paul Hodor, Meissner Robert S, James J. Perkins
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 143:29-39
Prostate cancer (PCa) initially responds to inhibition of androgen receptor (AR) signaling, but inevitably progresses to hormone ablation-resistant disease. Much effort is focused on optimizing this androgen deprivation strategy by improving hormone
Publikováno v:
In Tetrahedron Letters 1999 40(6):1103-1106
Autor:
Pascale V. Nantermet, Thomayant Prueksaritanont, William J. Ray, James J. Perkins, Chih-Tai Leu, Fang Chen, Azriel Schmidt, Mark E. Duggan, Viera Kasparcova, Sharon Adamski, Donald B. Kimmel, Leonard P. Freedman, SuJane Rutledge, T. Cusick, Brenda L Pennypacker, George D. Hartman, Jiabing Wang, P. Masarachia, Meissner Robert S, Shun-ichi Harada, Paul Hodor, Robert L. Vogel, Chang Bai, Hai-Zhuan Zhang, Sheila McElwee-Witmer, Helen J. Mitchell, Michael A. Gentile, Evan E. Opas, Angela Scafonas, Yuntae Kim
Publikováno v:
Journal of Biological Chemistry. 285:17054-17064
Selective androgen receptor modulators (SARMs) are androgen receptor (AR) ligands that induce anabolism while having reduced effects in reproductive tissues. In various experimental contexts SARMs fully activate, partially activate, or even antagoniz
Autor:
Soumya P. Sahoo, Donald B. Kimmel, P. Masarachia, Pascale V. Nantermet, Meissner Robert S, Fang Chen, William J. Ray, Dwight A. Towler, Shun Ichi Harada, Chang Bai, Angela Scafonas, Mark E. Duggan, Brenda L Pennypacker, Su Jane Rutledge, Azriel Schmidt, Gideon A. Rodan, Sheila McElwee-Witmer, Robert L. Vogel, Michael A. Gentile, George D. Hartman, Yuntae Kim
Publikováno v:
Journal of Biological Chemistry. 284:36367-36376
Androgen replacement therapy is a promising strategy for the treatment of frailty; however, androgens pose risks for unwanted effects including virilization and hypertrophy of reproductive organs. Selective Androgen Receptor Modulators (SARMs) retain