Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Meisam, Bakhshayeshi"'
Autor:
Vinay Bhatt, Ryan Dickerson, Christopher Argento, John Pieracci, Meisam Bakhshayeshi, Xiaotong Fu, Xiaohui Lu, Peter Clarner, Svetlana Bergelson, George M. Bou-Assaf, Wei-Chiang Chen
Publikováno v:
Human Gene Therapy Methods. 30:144-152
Recombinant adeno-associated virus (rAAV)-mediated gene therapy is a fast-evolving field in the biotechnology industry. One of the major challenges in developing a purification process for AAV gene therapy is establishing an effective yet scalable me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371c8e875f01b80c96012c68505767e2
https://doi.org/10.1089/hgtb.2019.088
https://doi.org/10.1089/hgtb.2019.088
Publikováno v:
Biotechnology journal. 16(1)
The development of recombinant adeno-associated virus (rAAV) gene therapies is becoming an increasing priority in the biotherapeutic landscape. One of the challenges associated with the production of rAAV is the formation of empty AAV particles that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19b99b71dadaf5ee47dafae95c312ac
https://pubmed.ncbi.nlm.nih.gov/33002276
https://pubmed.ncbi.nlm.nih.gov/33002276
Publikováno v:
Journal of Chromatography A. 1663:462744
Recombinant adeno-associated virus (AAV) has been broadly used as a delivery tool for gene therapy applications. The development of a robust purification process is essential for delivering high purity and quality AAV products to clinic. The short cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a272e0c23404aafb353a0d1ca36868f1
https://doi.org/10.1016/j.chroma.2021.462744
https://doi.org/10.1016/j.chroma.2021.462744
Autor:
Rachel Specht, Meisam Bakhshayeshi
Publikováno v:
PDA Journal of Pharmaceutical Science and Technology. 70:462-469
The goal of session 4.1 was to review the application of generic claims for viral clearance including low-pH/ Triton inactivation and viral filtration, as well as implementation of a quality by design (QbD) approach to assess viral clearance within d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4ed990b5d9a0d4a970f11275d5a18a
https://doi.org/10.5731/pdajpst.2016.006957
https://doi.org/10.5731/pdajpst.2016.006957
Autor:
Meisam Bakhshayeshi, Rachel Specht
Publikováno v:
PDA Journal of Pharmaceutical Science and Technology. 70:470-476
Viral clearance studies are an integral part of the downstream process development for purification of therapeutic proteins. Characteristics of the upstream process and the operational mode of the downstream process (e.g., batch vs continuous) can af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1c717e3bb0fa21ed751c6da4e2167c
https://doi.org/10.5731/pdajpst.2016.006965
https://doi.org/10.5731/pdajpst.2016.006965
Autor:
Wei Yuan, Achyuta Teella, Cathryn Ellen Olsen, Meisam Bakhshayeshi, Andrew L. Zydney, Hongyi Zhou
Publikováno v:
Journal of Membrane Science. :32-38
Although dextran retention tests are used extensively for characterizing ultrafiltration membranes, there is no standardization in the test methods or conditions. This is particularly important for hollow fiber membrane modules in which the degree of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa90b0c03933a180b260c64c3542f989
https://doi.org/10.1016/j.memsci.2012.06.020
https://doi.org/10.1016/j.memsci.2012.06.020
Publikováno v:
Journal of Membrane Science. :243-250
Dextran retention tests have become a standard method for characterizing ultrafiltration (UF) membranes. However, most quantitative analyses of dextran transport have been performed with flat sheet membranes using simple stirred cells in which the tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8924db6f550e9144dcfda0dbaf1cf14a
https://doi.org/10.1016/j.memsci.2011.09.047
https://doi.org/10.1016/j.memsci.2011.09.047
Autor:
Andrew L. Zydney, Nigel B. Jackson, Ralf Kuriyel, Dharmesh M. Kanani, Meisam Bakhshayeshi, Robert van Reis, Amit Mehta
Publikováno v:
Journal of Membrane Science. 379:239-248
Dextran sieving (or retention) tests have become a standard method for characterizing the pore size distribution of ultrafiltration membranes. The objective of this work was to extend this methodology to the analysis of parvovirus filtration membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d494152ee24d38a3a6029a006edd5ec7
https://doi.org/10.1016/j.memsci.2011.05.067
https://doi.org/10.1016/j.memsci.2011.05.067
Autor:
Nigel B. Jackson, Robert van Reis, Andrew L. Zydney, Amit Mehta, Ralf Kuriyel, Meisam Bakhshayeshi
Publikováno v:
Journal of Membrane Science. 379:260-267
Virus filtration is used extensively in bioprocessing applications; however, there is currently little fundamental understanding of the capture phenomenon or its dependence on the underlying membrane pore structure. The objective of this study was to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::838a2d4365ed87dead80ac52148341d3
https://doi.org/10.1016/j.memsci.2011.05.069
https://doi.org/10.1016/j.memsci.2011.05.069
Autor:
Scott Estes, Bing Guan, Thomas Ryll, Janet Lau, Sarthak Mane, John Pieracci, Shashi Prajapati, Meisam Bakhshayeshi, Lam Raga A. Markely, Lutfiye Kurt
Publikováno v:
Biotechnology progress. 30(2)
Product quality analyses are critical for developing cell line and bioprocess producing therapeutic proteins with desired critical product quality attributes. To facilitate these analyses, a high-throughput small-scale protein purification (SSP) is r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b4212aa5b61b3219cb62451c86a2dd
https://pubmed.ncbi.nlm.nih.gov/24449619
https://pubmed.ncbi.nlm.nih.gov/24449619