Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Meir Glick"'
Autor:
Elizabeth Joshi, Andy Liaw, Prabha Karnachi, Meir Glick, Yuting Xu, Matthew Tudor, Robert P. Sheridan, Falgun Shah, Juan C. Alvarez, Alan C. Cheng
Publikováno v:
Journal of Chemical Information and Modeling. 60:1969-1982
Given a particular descriptor/method combination, some quantitative structure-activity relationship (QSAR) datasets are very predictive by random-split cross-validation while others are not. Recent literature in modelability suggests that the limitin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fa5563d4937fc0756adda0e983dd47
https://doi.org/10.1021/acs.jcim.9b01067
https://doi.org/10.1021/acs.jcim.9b01067
Autor:
Viktor Pisarenko, Anja Muzdalo, Danny A. Bitton, Petr Mejzlik, Gregory L. Adams, Meir Glick, Kamila Clarova, Esteban Jenkins, Dzianis Hancharyk, Javier L. Baylon, Anna Gromek, Martin Spale, David Bednar, Charlie Chang, Anne Mai Wassermann, Oleg Ursu
Publikováno v:
Journal of chemical information and modeling. 62(5)
Therapeutic peptides offer potential advantages over small molecules in terms of selectivity, affinity, and their ability to target “undruggable” proteins that are associated with a wide range of pathologies. Despite their importance, there are c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ab84df102f573fd0b02fb2bc1cb63e
https://pubmed.ncbi.nlm.nih.gov/35192366
https://pubmed.ncbi.nlm.nih.gov/35192366
Autor:
Kelly Slocum, Jianmei Fan, Michael Dore, Palermo Mark G, Zhan Deng, Bakary-Barry Toure, Jorge Garcia-Fortanet, Dyuti Majumdar, Martin F. Hentemann, Nick Keen, Suzanne Zhu, Christopher Towler, Michael Shultz, William R. Sellers, Simon Mathieu, Denise Grunenfelder, Robert Koenig, Douglas C. Bauer, Shumei Liu, Jay Larrow, Victoriano Tamez, David Dunstan, Andreea Argintaru, Timothy Michael Ramsey, Zhouliang Chen, Gang Liu, Ying-Nan Chen, Rukundo Ntaganda, Bing Yu, Joanna Slisz, Hongyun Wang, Pascal D. Fortin, Christopher Sean Straub, Ji-Hu Zhang, Ping Wang, Laura R. LaBonte, Mitsunori Kato, Matthew J. Meyer, Fan Yang, Patrick James Sarver, Samuel B. Ho, Brant Firestone, Rajesh Karki, John F. Reilly, Troy Smith, Ho Man Chan, Cary Fridrich, John William Giraldes, Julie Boisclair, Chen Christine Hiu-Tung, Meir Glick, Zhao B. Kang, Morvarid Mohseni, Lawrence Blas Perez, Michael G. Acker, Sarah Williams, Matthew J. LaMarche, Martin Sendzik, Michelle Fodor, Huia-Xiang Hao, Peter Fekkes, Minying Pu, Travis Stams, Stanley Spence, Andriana Jouk
Publikováno v:
Journal of medicinal chemistry. 63(22)
SHP2 is a nonreceptor protein tyrosine phosphatase encoded by the PTPN11 gene and is involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also plays an important role in the programed cell death pathway (PD-1/PD-L1). As an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345804676325a445ebbb9ef600ced79a
https://pubmed.ncbi.nlm.nih.gov/32910655
https://pubmed.ncbi.nlm.nih.gov/32910655
Autor:
Victoria Kutilek, Zhao Wang, Rafael Fernandez, James R. Tata, Li Zheng, Xuan Mo, Brian D. Dill, Meir Glick, Nirodhini Siriwardana, Jonathan D. Mortison, Ivan Cornella-Taracido, Brian M. Andresen, Julie Di Bernardo, Yuting Xu, Andy Liaw, Matthew Christopher, Oleg Ursu, Benjamin Ruprecht, Huijun Wang, An Chi
Publikováno v:
Nature chemical biology. 16(10)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fae67c605f7ac45e6ea429f134b9a6
https://pubmed.ncbi.nlm.nih.gov/32690943
https://pubmed.ncbi.nlm.nih.gov/32690943
Autor:
Peter S Kutchukian, Nadya Y Vasilyeva, Jordan Xu, Mika K Lindvall, Michael P Dillon, Meir Glick, John D Coley, Natasja Brooijmans
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48476 (2012)
Medicinal chemists' "intuition" is critical for success in modern drug discovery. Early in the discovery process, chemists select a subset of compounds for further research, often from many viable candidates. These decisions determine the success of
Externí odkaz:
https://doaj.org/article/8278d8c8630b4124807ed15a08836945
Autor:
Meir Glick, Sean J. Fox, Charlie Chang, Erica Cook, Robert P. Sheridan, David M. Tellers, Iain M. Wallace, Dante A. Pertusi, Anne Mai Wassermann, Richard J. O. Barnard, Huijun Wang, Peter S. Kutchukian
Publikováno v:
Drug Discovery Today. 23:151-160
Increasing amounts of biological data are accumulating in the pharmaceutical industry and academic institutions. However, data does not equal actionable information, and guidelines for appropriate data capture, harmonization, integration, mining, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d78092019dfbbf1ee9e4dcfe56025e0
https://doi.org/10.1016/j.drudis.2017.09.004
https://doi.org/10.1016/j.drudis.2017.09.004
Autor:
Michelle F. Homsher, Louis Locco, Shannon L. Stahler, Michael Weber, Jennifer E. Nothstein, Eleftheria N. Finger, Evelyn Boots, Mee Ra Heo, Amita Patel, Gregory O'Donnell, Alex Wolicki, Michael F.A. Finley, J. Christopher Culberson, Paul Zuck, Juncai Meng, Kenneth Roberts, David J. Bell, Peter S. Kutchukian, Gregory C. Adam, Carissa Quinn, Patrick Cocchiarella, Meir Glick, S. Alex May, Victor N. Uebele, Edward Hudak, Brian Squadroni, Daniel Riley, Andrew Rusinko, Kelli Solly, Michelle Hartnett, Dante A. Pertusi, Adam Amoss, Anthony Kreamer, Tara White, Anne Mai Wassermann
Publikováno v:
SLAS Discovery. 22:995-1006
High-throughput screening (HTS) is a widespread method in early drug discovery for identifying promising chemical matter that modulates a target or phenotype of interest. Because HTS campaigns involve screening millions of compounds, it is often desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561e5ff95861fbde45cdff3f2132d673
https://doi.org/10.1177/2472555217706058
https://doi.org/10.1177/2472555217706058
Autor:
Peter Saradjian, John P. Santa Maria, Peter J. Dandliker, Chad Chamberlin, Gregory C. Adam, Nicholas Murgolo, Clifton E. Barry, Elliott B. Nickbarg, Paul Zuck, Peter S. Kutchukian, Charles G. Garlisi, Lihu Yang, Yumi Park, Helena I. Boshoff, Katherine Young, David B. Olsen, Meir Glick, Michael D. Altman
Publikováno v:
ACS Chemical Biology. 12:2448-2456
Though phenotypic and target-based high-throughput screening approaches have been employed to discover new antibiotics, the identification of promising therapeutic candidates remains challenging. Each approach provides different information, and unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b660e8c1c982639dd6ee20c49d515301
https://doi.org/10.1021/acschembio.7b00468
https://doi.org/10.1021/acschembio.7b00468
Autor:
Chris L. Waller, Charlie Zhenyu Chang, Frank K Brown, Farida Kopti, Scott A. Johnson, Meir Glick
Publikováno v:
The AAPS Journal. 19:1255-1263
Merck & Co., Inc., Kenilworth, NJ, USA, is undergoing a transformation in the way that it prosecutes R&D programs. Through the adoption of a “model-driven” culture, enhanced R&D productivity is anticipated, both in the form of decreased attrition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf340b77b7a83ca63e283a902e49730e
https://doi.org/10.1208/s12248-017-0124-2
https://doi.org/10.1208/s12248-017-0124-2
Autor:
Lili Xie, Charles R. Dean, Colin Osborne, Grazia Piizzi, Som Wattanasin, Jade Bojkovic, Francois Lenoir, Eugene Liu, Yipin Lu, Meir Glick, Donghui Yu, Tommasi Ruben A, Lawrence G. Hamann, Bing Wang, John Ryan Kerrigan, David Thomas Parker, Markus Dobler, Srijan Ranjitkar, JoAnn Dzink-Fox, Yunshan Peng, Leanne Lanieri, Hongming Wang, Xia Yang, David McKenney, Jill Nunez, Anup Patnaik, Maria-Dawn Lilly, Elizabeth R. Sprague
Publikováno v:
Journal of Medicinal Chemistry. 60:5002-5014
Over the past several decades, the frequency of antibacterial resistance in hospitals, including multidrug resistance (MDR) and its association with serious infectious diseases, has increased at alarming rates. Pseudomonas aeruginosa is a leading cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094ae843eba8c8bf8c94ae8350980ced
https://doi.org/10.1021/acs.jmedchem.7b00377
https://doi.org/10.1021/acs.jmedchem.7b00377