Výsledky vyhledávání - "Meiquing Liu"

The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:2959-2966

Using a combination of traditional Medicinal Chemistry/SAR analysis, crystallography, and molecular modeling, we have designed and synthesized a series of novel, highly potent NNRTIs that possess broad antiviral activity against a number of key clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f89230b4fd01e13b8d56f9729d01d8e
https://doi.org/10.1016/j.bmcl.2008.03.064

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Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses

Publikováno v: Journal of medicinal chemistry. 51(20)

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) have been shown to be a key component of highly active antiretroviral therapy (HAART). The use of NNRTIs has become part of standard combination antiviral therapies producing clinical outcomes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e02ba1796bf5243d6244803e92e004
https://pubmed.ncbi.nlm.nih.gov/18826204

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Akademický článek

Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses.

Publikováno v: Journal of Medicinal Chemistry; Oct2008, Vol. 51 Issue 20, p6503-6511, 9p

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