Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Meiping Chang"'
Autor:
Steve Huhn, Meiping Chang, Amit Kumar, Ren Liu, Bo Jiang, Michael Betenbaugh, Henry Lin, Gregg Nyberg, Zhimei Du
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104074- (2022)
Summary: Genetic instability of Chinese hamster ovary (CHO) cells is implicated in production inconsistency through poorly defined mechanisms. Using a multi-omics approach, we analyzed the variations of CHO lineages derived from CHO-K1 cells. We iden
Externí odkaz:
https://doaj.org/article/7cea1391b1c1462189adca184eb35fe2
Autor:
Brooks Hopkins, Justin Fisher, Meiping Chang, Xiaoyan Tang, Zhimei Du, William J. Kelly, Zuyi Huang
Publikováno v:
Cells, Vol 11, Iss 10, p 1701 (2022)
The growth of T cells ex vivo for the purpose of T cell therapies is a rate-limiting step in the overall process for cancer patients to achieve remission. Growing T cells is a fiscally-, time-, and resource-intensive process. Cytokines have been show
Externí odkaz:
https://doaj.org/article/cdb45f5adafa4db4bece1b1ef2d96cf7
The use of transposase in cell line development (CLD) programs has experienced increased popularity over the past decade. However, few studies have described the mechanism of action and the genomic and phenotypic characteristics of clones derived fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84c4852a676730d10202d3100c08b7c5
https://doi.org/10.22541/au.165816370.02613398/v1
https://doi.org/10.22541/au.165816370.02613398/v1
Autor:
Kedir N. Turi, Allan Paras, Carolina B. López, Ana María Cárdenas, Agnieszka Jozwik, Kristen A. Feemster, Yan Sun, Sébastien A. Felt, Emna Achouri, Christopher Chiu, Larry J. Anderson, David C. Nickle, Maximillian S. Habibi, Shaon Sengupta, Tina V. Hartert, Meiping Chang
Publikováno v:
Nat Microbiol
Respiratory syncytial virus (RSV) causes respiratory illness in children, immunosuppressed individuals and the elderly. However, the viral factors influencing the clinical outcome of RSV infections remain poorly defined. Defective viral genomes (DVGs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ffb6df3aa59918b9aa027b284290443
https://doi.org/10.1038/s41564-021-00882-3
https://doi.org/10.1038/s41564-021-00882-3
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 119(7)
Robust manufacturing production of natural killer (NK) cells has been challenging in allogeneic NK cell-based therapy. Here, we compared the impact of cytokines on NK cell expansion by developing recombinant K562 feeder cell lines expressing membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372f49e4864a48dc90ad5b34a4011f7c
https://pubmed.ncbi.nlm.nih.gov/35297033
https://pubmed.ncbi.nlm.nih.gov/35297033
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 119(5)
The CDK4/6 inhibitor has been shown to increase recombinant protein productivity in Chinese hamster ovary (CHO) cells. Therefore, we investigated the mechanism that couples cell-cycle inhibitor (CCI) treatment with protein productivity utilizing prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0079ae6b8e16ef531b47a4a3f261f0d
https://pubmed.ncbi.nlm.nih.gov/35112712
https://pubmed.ncbi.nlm.nih.gov/35112712
Autor:
Meiping Chang, Amit Kumar, Swetha Kumar, Steven Huhn, Winston Timp, Michael Betenbaugh, Zhimei Du
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 119(4)
In this study, we examined DNA methylation and transcription profiles of recombinant clones derived from two different Chinese hamster ovary hosts. We found striking epigenetic differences between the clones, with global hypomethylation in the host 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8bfb41415278a76b9b948431de33516
https://pubmed.ncbi.nlm.nih.gov/35028935
https://pubmed.ncbi.nlm.nih.gov/35028935
Autor:
Steve Huhn, Meiping Chang, Amit Kumar, Ren Liu, Bo Jiang, Michael Betenbaugh, Henry Lin, Gregg Nyberg, Zhimei Du
Publikováno v:
iScience. 25(4)
Genetic instability of Chinese hamster ovary (CHO) cells is implicated in production inconsistency through poorly defined mechanisms. Using a multi-omics approach, we analyzed the variations of CHO lineages derived from CHO-K1 cells. We identify an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420dc0e7f1e8b84ae2a945a6788b2cfa
https://pubmed.ncbi.nlm.nih.gov/35355517
https://pubmed.ncbi.nlm.nih.gov/35355517
Autor:
Steve Huhn, Meiping Chang, Amit Kumar, Ren Liu, Bo Jiang, Michael Betenbaugh, Henry Lin, Gregg Nyberg, Zhimei Du
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c314ec04c36a34b5c5e1d0e3a9eba21
https://doi.org/10.2139/ssrn.3940628
https://doi.org/10.2139/ssrn.3940628
Autor:
Meiping Chang, Leah Cuthbertson, Trevor T. Hansel, Christopher Chiu, Tanushree Tunstall, Ryan S Thwaites, Amber Owen, Agnieszka Jozwik, Peter J. M. Openshaw, Augusto Varese, Phillip James, Miriam F. Moffatt, Cecilia Johansson, Allan Paras, Freja C M Kirsebom, Maximillian S. Habibi, David C. Nickle
Publikováno v:
Science. 370
INTRODUCTION Even with intimate exposure to a virus, some people fail to become infected. Variable transmission partly depends on the dose and duration of exposure but is also governed by the immune status of the host, such as the presence of specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a71cf99ff3456573752d348202ac097
https://doi.org/10.1126/science.aba9301
https://doi.org/10.1126/science.aba9301