Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Meindert H. Lamers"'
Polymerization and editing modes of a high-fidelity DNA polymerase are linked by a well-defined path
Autor:
Thomas Dodd, Margherita Botto, Fabian Paul, Rafael Fernandez-Leiro, Meindert H. Lamers, Ivaylo Ivanov
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
In high fidelity DNA polymerases the exonuclease site is distal from the polymerization site and it is unknown how the primer strand travels between the two sites when mis-incorporated nucleotides must be removed. Here, the authors perform MD simulat
Externí odkaz:
https://doaj.org/article/ed53db85cf324dffb2be1a08c1015c86
Autor:
Soledad Baños-Mateos, Anne-Marie M. van Roon, Ulla F. Lang, Sarah L. Maslen, J. Mark Skehel, Meindert H. Lamers
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The polymerase and histidinol phosphatase (PHP) domain in the DNA polymerase DnaE1 is essential for mycobacterial high-fidelity DNA replication. Here, the authors determine the DnaE1 crystal structure, which reveals the PHP-exonuclease mechanism that
Externí odkaz:
https://doaj.org/article/5fc944f0ddb6405aa8447da27bcce74f
Autor:
Joana A. Santos, Meindert H. Lamers
Publikováno v:
Antibiotics, Vol 9, Iss 11, p 776 (2020)
Multidrug resistance is a worldwide problem that is an increasing threat to global health. Therefore, the development of new antibiotics that inhibit novel targets is of great urgency. Some of the most successful antibiotics inhibit RNA transcription
Externí odkaz:
https://doaj.org/article/8c3f0c27b29942b9bc8ee57999680763
Autor:
Sophia Gessner, Zela Alexandria-Mae Martin, Michael A Reiche, Joana A Santos, Ryan Dinkele, Atondaho Ramudzuli, Neeraj Dhar, Timothy J de Wet, Saber Anoosheh, Dirk M Lang, Jesse Aaron, Teng-Leong Chew, Jennifer Herrmann, Rolf Müller, John D McKinney, Roger Woodgate, Valerie Mizrahi, Česlovas Venclovas, Meindert H Lamers, Digby F Warner
Publikováno v:
eLife, Vol 12 (2023)
A DNA damage-inducible mutagenic gene cassette has been implicated in the emergence of drug resistance in Mycobacterium tuberculosis during anti-tuberculosis (TB) chemotherapy. However, the molecular composition and operation of the encoded ‘mycoba
Externí odkaz:
https://doaj.org/article/9340d5204dad4cac96d701c78d904d63
Publikováno v:
ACS Omega. 8:8285-8292
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38d8b518c663dc1b13d3d514225368de
https://doi.org/10.1021/acsomega.2c06577
https://doi.org/10.1021/acsomega.2c06577
Publikováno v:
Nucleic Acids Research, 50(11), 6224-6234. OXFORD UNIV PRESS
Nucleic Acids Research, 50(11), 6224-6234. Oxford University Press
Nucleic Acids Research, 50(11), 6224-6234. Oxford University Press
DNA mismatch repair removes mis-incorporated bases after DNA replication and reduces the error rate a 100–1000-fold. After recognition of a mismatch, a large section of up to a thousand nucleotides is removed from the daughter strand followed by re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992255c41a430229c012cdef4a6dca45
https://doi.org/10.1093/nar/gkac432
https://doi.org/10.1093/nar/gkac432
Autor:
Joana A. Santos, Kęstutis Timinskas, Meindert H. Lamers, Česlovas Venclovas, Digby F. Warner, Sophia J. Gessner
Publikováno v:
bioRxiv
The mycobacterial mutasome – minimally comprising ImuA’, ImuB, and DnaE2 proteins – has been implicated in DNA damage-induced mutagenesis inMycobacterium tuberculosis. ImuB, predicted to enable mutasome function via its interaction with the β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c049ddb68b8fc7110120cb8f84c410
https://doi.org/10.1101/2023.03.28.534377
https://doi.org/10.1101/2023.03.28.534377
Exonucleases are essential enzymes that remove nucleotides from free DNA ends during DNA replication, DNA repair and telomere maintenance. Due to their essential role, they are potential targets for novel anticancer and antimicrobial drugs but have s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d3c40ce112e409935f94c37ff3bf0f6
https://doi.org/10.1101/2022.09.12.507544
https://doi.org/10.1101/2022.09.12.507544
DNA replication introduces thousands of RNA primers into the lagging strand that need to be removed for replication to be completed. In Escherichia coli when the replicative DNA polymerase Pol IIIα terminates at a previously synthesized RNA primer,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4042d094d446903bf42dbc29e017cb80
https://doi.org/10.1101/2022.08.02.502465
https://doi.org/10.1101/2022.08.02.502465
Autor:
Melissa D. Chengalroyen, Mandy K. Mason, Alessandro Borsellini, Raffaella Tassoni, Garth L. Abrahams, Sasha Lynch, Yong-Mo Ahn, Jon Ambler, Katherine Young, Brendan M. Crowley, David B. Olsen, Digby F. Warner, Clifton E. Barry III, Helena I. M. Boshoff, Meindert H. Lamers, Valerie Mizrahi
Publikováno v:
ACS Infectious Diseases, 8(3), 612-625. AMER CHEMICAL SOC
Natural products provide a rich source of potential antimicrobials for treating infectious diseases for which drug resistance has emerged. Foremost among these diseases is tuberculosis. Assessment of the antimycobacterial activity of nargenicin, a na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3fb2ed0c508f40ee8c1ebeb5a93f63a
https://hdl.handle.net/1887/3514350
https://hdl.handle.net/1887/3514350