Zobrazeno 1 - 10
of 483
pro vyhledávání: '"Meindert Danhof"'
Autor:
Heleen J. Blussé van Oud-Alblas, Margreke J. E. Brill, Mariska Y. M. Peeters, Dick Tibboel, Meindert Danhof, Catherijne A. J. Knibbe
Publikováno v:
BMC Anesthesiology, Vol 19, Iss 1, Pp 1-12 (2019)
Abstract Background In adolescents limited data are available on the pharmacokinetics (PK) and pharmacodynamics (PD) of propofol. In this study we derived a PK-PD model for propofol in adolescents undergoing idiopathic scoliosis surgery with an intra
Externí odkaz:
https://doaj.org/article/2e21509f15884249a1bf9c8f16b20547
Autor:
Amit Taneja, An Vermeulen, Dymphy R.H. Huntjens, Meindert Danhof, Elizabeth C.M. De Lange, Johannes H. Proost
Publikováno v:
Data in Brief, Vol 8, Iss , Pp 1433-1437 (2016)
We provide the reader with relevant data related to our recently published paper, comparing two mathematical models to describe prolactin turnover in rats following one or two doses of the dopamine D2 receptor antagonists risperidone, paliperidone an
Externí odkaz:
https://doaj.org/article/64448badcc4a41b9b559f9d8583b6b3d
Autor:
Chi Hse Tang, Mathieu Peyrou, Jonathan P. Mochel, Meindert Danhof, Dean F. Rigel, Jérôme M. Giraudel
Publikováno v:
European Journal of Pharmaceutical Sciences. 128:103-111
Simultaneous blockade of angiotensin receptors and enhancement of natriuretic peptides (NP) by the first-in-class angiotensin receptor neprilysin (NEP) inhibitor sacubitril/valsartan constitutes an effective approach to treating heart failure. This s
Autor:
Meindert Danhof, Sheraz Gul, Dymphy Huntjens, Piet H. van der Graaf, Solene Rolland, Maria Kuzikov, Wilhelmus E. A. de Witte, Victoria Georgi, Amaury Ernesto Fernandez-Montalvan, Philip Gribbon, Joost W Versfelt, Gesa Witt, Elizabeth C. M. de Lange
Publikováno v:
British Journal of Pharmacology
and the cAMP turnover.\n .\n receptor antagonists, it has been hypothesized that fast receptor binding kinetics cause fewer side effects, because part of the dynamics of the dopaminergic system is preserved by displacement of these antagonists.\n rec
Autor:
Meindert Danhof, Piet H. van der Graaf, Elizabeth C. M. de Lange, Lambertus A. Peletier, Vivi Rottschäfer, Wilhelmus E. A. de Witte
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics
Journal of Pharmacokinetics and Pharmacodynamics, 45(4), 621-635
Journal of Pharmacokinetics and Pharmacodynamics, 45(4), 621-635
Drug–target binding kinetics (as determined by association and dissociation rate constants, kon and koff) can be an important determinant of the kinetics of drug action. However, the effect compartment model is used most frequently instead of a tar
Autor:
Julie A. Stone, Huub Jan Kleijn, Eline M. T. van Maanen, Mary J. Savage, Maria S. Michener, Matthew E. Kennedy, Tamara J. van Steeg, Maurice J. Ahsman, Meindert Danhof
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 365:507-518
The abnormal accumulation of amyloid-β (Aβ) in the brain parenchyma has been posited as a central event in the pathophysiology of Alzheimer's disease. Recently, we have proposed a systems pharmacology model of the amyloid precursor protein (APP) pa
Autor:
Huixin Yu, Pyry A. J. Välitalo, Dick Tibboel, Piet H. van der Graaf, Trevor N. Johnson, Amin Rostami-Hodjegan, Elisa A. M. Calvier, Catherijne A. J. Knibbe, Elke H. J. Krekels, Meindert Danhof
Publikováno v:
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
For scaling drug plasma clearance (CLp) from adults to children, extrapolations of population pharmacokinetic (PopPK) covariate models between drugs sharing an elimination pathway have enabled accelerated development of pediatric models and dosing re
Autor:
Nico C. B. de Jager, Meindert Danhof, Sven C. van Dijkman, Oscar Della Pasqua, Willem M. Rauwé
Publikováno v:
Clinical Pharmacokinetics. 57:1039-1053
In this study, we evaluate the performance of allometric concepts to predict the implications of age and size on the pharmacokinetics of lamotrigine, and assess the dose rationale across different age groups from 0.2 to 91 years.An allometrically sca
Publikováno v:
British Journal of Clinical Pharmacology. 84:97-111
Aims Population pharmacokinetic modelling has been widely used across many therapeutic areas to identify sources of variability, which are incorporated into models as covariate factors. Despite numerous publications on pharmacokinetic drug–drug int
Autor:
Dirk-Jan van den Berg, Elizabeth C. M. de Lange, Pyry A. J. Välitalo, Margot W. Beukers, Johan G. C. van Hasselt, Walter Krauwinkel, An Vermeulen, Robin Hartman, Yumi Yamamoto, Meindert Danhof, Yin Cheong Wong, Dymphy Huntjens, Johannes H. Proost
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
Drug development targeting the central nervous system (CNS) is challenging due to poor predictability of drug concentrations in various CNS compartments. We developed a generic physiologically based pharmacokinetic (PBPK) model for prediction of drug