Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function

Autor: Meinders, Marjolein, Kulu, Divine I., van de Werken, Harmen J.G., Hoogenboezem, Mark, Janssen, Hans, Brouwer, Rutger W.W., van Ijcken, Wilfred F.J., Rijkers, Erik-Jan, Demmers, Jeroen A.A., Krüger, Imme, van den Berg, Timo K., Suske, Guntram, Gutiérrez, Laura, Philipsen, Sjaak

Publikováno v: In Blood 19 March 2015 125(12):1957-1967

Characterization and evolutionary origin of novel C2H2 zinc finger protein (ZNF648) required for both erythroid and megakaryocyte differentiation in humans

Autor: Ferguson, Daniel C. J., Mokim, Juraidah Haji, Meinders, Marjolein, Moody, Edmund R. R., Williams, Tom A., Cooke, Sarah, Trakarnsanga, Kongtana, Daniels, Deborah E., Ferrer-Vicens, Ivan, Shoemark, Deborah, Tipgomut, Chartsiam, Macinnes, Katherine A., Wilson, Marieangela C., Singleton, Belinda K., Frayne, Jan

Publikováno v: Haematologica

Human ZNF648 is a novel poly C-terminal C2H2 zinc finger (ZnF) protein identified amongst the most dysregulated proteins in erythroid cells differentiated from induced pluripotent stem cells. Its nuclear localization and structure indicate it is like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8155727071d81d5a85cd43df45e100c
http://europepmc.org/articles/PMC8561289

The RNA-binding protein ATXN2 is expressed during megakaryopoiesis and may control timing of gene expression

Autor: Hansen, Marten, Zeddies, Sabrina, Meinders, Marjolein, di Summa, Franca, van Alphen, Floris P J, Hoogendijk, Arjan J, Moore, Kat S, Halbach, Melanie, Gutiérrez, Laura, van den Biggelaar, Maartje, Thijssen-Timmer, Daphne C, Auburger, Georg W J, van den Akker, Emile, von Lindern, Marieke, Rollmann, Ewa, Anatomie en fysiologie, Afd Pharmaceutics, Pharmaceutics

Publikováno v: International Journal of Molecular Sciences, 21(3). MDPI AG
International Journal of Molecular Sciences
Volume 21
Issue 3
International Journal of Molecular Sciences, Vol 21, Iss 3, p 967 (2020)
International journal of molecular sciences, 21(3):967. Multidisciplinary Digital Publishing Institute (MDPI)
RUO. Repositorio Institucional de la Universidad de Oviedo
instname

Megakaryopoiesis is the process during which megakaryoblasts differentiate to polyploid megakaryocytes that can subsequently shed thousands of platelets in the circulation. Megakaryocytes accumulate mRNA during their maturation, which is required for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6868e9c6ce96a52ff392669db8f2d246
http://www.scopus.com/inward/record.url?scp=85079031986&partnerID=8YFLogxK

An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells

Autor: Trakarnsanga, Kongtana, Griffiths, Rebecca E., Wilson, Marieangela C., Blair, Allison, Satchwell, Timothy J., Meinders, Marjolein, Cogan, Nicola, Kupzig, Sabine, Kurita, Ryo, Nakamura, Yukio, Toye, Ashley M., Anstee, David J., Frayne, Jan

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Nature Communications
Trakarnsanga, K, Griffiths, R E, Wilson, M C, Blair, A, Satchwell, T J, Meinders, M, Cogan, N, Kupzig, S, Kurita, R, Nakamura, Y, Toye, A M, Anstee, D J & Frayne, J 2017, ' An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells ', Nature Communications, vol. 8, 14750 . https://doi.org/10.1038/ncomms14750

With increasing worldwide demand for safe blood, there is much interest in generating red blood cells in vitro as an alternative clinical product. However, available methods for in vitro generation of red cells from adult and cord blood progenitors d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::31f6d2b19bcbbfbb347ebb321ac7ff31
https://doaj.org/article/43660dc1c27e4e12acb966c38920743b

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