Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Meiliana Tjandra"'
Autor:
Cindy Li, Xu Zang, Vijay Sethuraman, Xiaoyu Shen, Johanne Blais, Heinz E. Moser, Kyuto Tashiro, Ellie Growcott, Ramadevi Prathapam, Anthony Casarez, Aregahegn Yifru, Charles Vitt, David McKenney, Tsuyoshi Uehara, Patrick J Rudewicz, Fengxia Li, Hongqiu Guo, Adriana K. Jones, Louis E. Metzger, Wanben Gong, Jacob Shaul, Alun Bermingham, Taryn Cariaga, Richard Colvin, Xiaodong Lin, Dita M. Rasper, Mika Lindvall, Dazhi Tang, Vladimir Capka, Steven Whitebread, Sara Lopez, Meiliana Tjandra, Qingming Zhu, Nancy Turner, Robert Lowell Simmons, Charles R. Dean, Alex Fekete, Folkert Reck
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:748-755
Metallo-β-lactamases (MBLs), such as New Delhi metallo-β-lactamase (NDM-1) have spread world-wide and present a serious threat. Expression of MBLs confers resistance in Gram-negative bacteria to all classes of β-lactam antibiotics, with the except
Autor:
Patrick S. Lee, Guillaume Lapointe, Ann Marie Madera, Robert L. Simmons, Wenjian Xu, Aregahegn Yifru, Meiliana Tjandra, Subramanian Karur, Alice Rico, Katherine Thompson, Jade Bojkovic, Lili Xie, Kyoko Uehara, Amy Liu, Wei Shu, Cornelia Bellamacina, David McKenney, Laura Morris, George R. Tonn, Colin Osborne, Bret M. Benton, Laura McDowell, Jiping Fu, Zachary K. Sweeney
Publikováno v:
Journal of medicinal chemistry. 61(20)
This report summarizes the identification and synthesis of novel LpxC inhibitors aided by computational methods that leveraged numerous crystal structures. This effort led to the identification of oxazolidinone and isoxazoline inhibitors with potent
Autor:
Feng Sun, David Thomas Parker, Friedrich Schuerch, Silvio Roggo, Xiaolin Li, Zachary Kevin Sweeney, Li Cao, Nicole Meier, Bernard Riss, Christian Guenat, Wei Li, Zhaobo Gao, Jiping Fu, Jibin Zhao, Subramanian Karur, Wang Ruidong, Andrew H. Weiss, Regis Denay, Alexey Rivkin, Su Xu, Harald Schroeder, Michael Paul Capparelli, Simon Ng, Quanbing Wu, Xin Xiong, Weikuan Li, Wosenu Mergo, Christopher Becker, Robert Lowell Simmons, Amy Lu, Gai Yu, Wenjian Xu, Peichao Lu, Nicolas Wenger, Christian Zürcher, Thomas Lochmann, Meiliana Tjandra, Alexandre Luneau, Hongyong Kim, Aregahegn Yifru, Yunshan Peng, Fabrice Gallou, Jianguang Zhou, Roger Aki Fujimoto, Michael Wang
Publikováno v:
Bioorganicmedicinal chemistry. 26(4)
Synthetic modification of cyclosporin A at P3-P4 positions led to the discovery of NIM258, a next generation cyclophilin inhibitor with excellent anti-hepatitis C virus potency, with decreased transporter inhibition, and pharmacokinetics suitable for
Autor:
Brigitte Wiedmann, Michael Wang, Andrew H. Weiss, Silvio Roggo, David Thomas Parker, Robert Elling, Jiping Fu, Zachary Kevin Sweeney, Markus Furegati, Kwan Leung, Robert Lowell Simmons, Aregahegn Yifru, Subramanian Karur, Yunshan Peng, Shengtian Yang, Roger Aki Fujimoto, Lili Xie, Alexey Rivkin, Michael Paul Capparelli, Linda Xiao, Imad Hanna, Charlotte Miault, Simon Ng, Christopher Becker, Wosenu Mergo, Theresa Kasprzyk, Dallas Bednarczyk, Peichao Lu, Mark Knapp, Meiliana Tjandra, Bo Zhou, Xiaolin Li, Wenjian Xu
Publikováno v:
Journal of medicinal chemistry. 57(20)
Nonimmunosuppressive cyclophilin inhibitors have demonstrated efficacy for the treatment of hepatitis C infection (HCV). However, alisporivir, cyclosporin A, and most other cyclosporins are potent inhibitors of OATP1B1, MRP2, MDR1, and other importan
Publikováno v:
Journal of the American Chemical Society. 131:9648-9650
We describe the first total synthesis of (-)-himandrine, a member of the class II galbulimima alkaloids. Noteworthy features of this chemistry include a diastereoselective Diels-Alder reaction in the rapid synthesis of the tricycle ABC-ring system in
Publikováno v:
ChemInform. 42
A striking “matched” double asymmetric induction is observed when enantioenriched 2-arylindoles such as (I) are oxidized in the presence of a peptide-catalyst and a coupling agent.
Catalytic enantioselective indole oxidation is a process of particular relevance to the chemistry of complex alkaloids, as it has been implicated in their biosynthesis. In the context of synthetic methodology, catalytic enantioselective indole oxidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e6142b35fc64bcac8e111059b069526
https://europepmc.org/articles/PMC3142352/
https://europepmc.org/articles/PMC3142352/
Autor:
Ronald N. Zuckermann, Kristin M. Brinner, Deborah H. Charych, Margot G. Paulick, Kathryn M. Hart, Meiliana Tjandra
Publikováno v:
Journal of combinatorial chemistry. 8(3)
We have developed a method for the rapid and unambiguous identification of sequences of hit compounds from one-bead-one-compound combinatorial libraries of peptide and peptoid ligands. The approach uses a cleavable linker that is hydrophilic to help
Publikováno v:
Journal of the American Chemical Society. 128:8126-8127
We describe the total synthesis of (+)- and (-)-galbulimima alkaloid 13. The absolute stereochemistry of natural (-)-galbulimima alkaloid 13 is revised to 2S. Sequential use of catalytic cross-coupling and cross-metathesis reactions followed by an in
Publikováno v:
Synfacts. 2009:1305-1305