Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Meilandt WJ"'
Autor:
Le Pichon, CE, Meilandt, WJ, Dominguez, S, Solanoy, H, Lin, H, Ngu, H, Gogineni, A, Ghosh, AS, Jiang, Z, Lee, S-H, Maloney, J, Gandham, VD, Pozniak, CD, Wang, B, Lee, S, Siu, M, Patel, S, Modrusan, Z, Liu, X, Rudhard, Y, Baca, M, Gustafson, A, Kaminker, J, Carano, RAD, Huang, EJ, Foreman, O, Weimer, R, Scearce-Levie, K, Lewcock, JW, Sease, Neurodegenerative
Publikováno v:
Le Pichon, CE; Meilandt, WJ; Dominguez, S; Solanoy, H; Lin, H; Ngu, H; et al.(2017). Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. SCIENCE TRANSLATIONAL MEDICINE, 9(403). doi: 10.1126/scitranslmed.aag0394. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1481v5tb
Hallmarks of chronic neurodegenerative disease include progressive synaptic loss and neuronal cell death, yet the cellular pathways that underlie these processes remain largely undefined. We provide evidence that dual leucine zipper kinase (DLK) is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::ee82a5ec36d230fae12b7afd234dd385
http://www.escholarship.org/uc/item/1481v5tb
http://www.escholarship.org/uc/item/1481v5tb
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Schauer SP; Department of Translational Medicine, Genentech, Inc., South San Francisco, California, USA., Cho CH; Department of Human Pathobiology and OMNI Reverse Translation, Genentech, Inc., South San Francisco, California, USA., Novikova G; Department of Bioinformatics, Genentech, Inc., South San Francisco, California, USA., Roth GA; Department of Preclinical and Translational Pharmacokinetics and Pharmacodynamics, Genentech, Inc., South San Francisco, California, USA., Lee J; Department of Translational Medicine, Genentech, Inc., South San Francisco, California, USA., Sharma AD; Department of Human Pathobiology and OMNI Reverse Translation, Genentech, Inc., South San Francisco, California, USA., Foley AR; Department of BioAnalytical Sciences, Genentech, Inc., South San Francisco, California, USA., Ng C; Department of BioAnalytical Sciences, Genentech, Inc., South San Francisco, California, USA., Shen P; Department of Safety Assessment Pathology, Genentech, Inc., South San Francisco, California, USA., Choi M; Department of Microchemistry, Proteomics, Lipidomics, and Next Generation Sequencing, Genentech, Inc., South San Francisco, California, USA., Ma TP; Department of Microchemistry, Proteomics, Lipidomics, and Next Generation Sequencing, Genentech, Inc., South San Francisco, California, USA., Phu L; Department of Microchemistry, Proteomics, Lipidomics, and Next Generation Sequencing, Genentech, Inc., South San Francisco, California, USA., Budayeva HG; Department of Microchemistry, Proteomics, Lipidomics, and Next Generation Sequencing, Genentech, Inc., South San Francisco, California, USA., Cheung TK; Department of Microchemistry, Proteomics, Lipidomics, and Next Generation Sequencing, Genentech, Inc., South San Francisco, California, USA., Lalehzadeh G; Department of Neuroscience, Genentech, Inc., South San Francisco, California, USA., Imperio J; Department of Neuroscience, Genentech, Inc., South San Francisco, California, USA., Ngu H; Department of Research Pathology, Genentech, Inc., South San Francisco, California, USA., Etxeberria A; Department of Neuroscience, Genentech, Inc., South San Francisco, California, USA., Liang Y; Department of Microchemistry, Proteomics, Lipidomics, and Next Generation Sequencing, Genentech, Inc., South San Francisco, California, USA., Rezzonico MG; Department of Bioinformatics, Genentech, Inc., South San Francisco, California, USA., Dourado M; Department of Neuroscience, Genentech, Inc., South San Francisco, California, USA., Huang K; Department of Translational Medicine, Genentech, Inc., South San Francisco, California, USA., Lai Z; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA., Hokom M; Department of BioAnalytical Sciences, Genentech, Inc., South San Francisco, California, USA., Pandya NJ; Department of Human Pathobiology and OMNI Reverse Translation, Genentech, Inc., South San Francisco, California, USA., Newton D; Roche Informatics, Hoffmann-La Roche, Ltd., Mississauga, Ontario, Canada., Abdel-Haleem AM; Roche Informatics, Hoffmann-La Roche, Ltd., Mississauga, Ontario, Canada., Chan P; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, USA., Lee D; Department of Safety Assessment Toxicology, Genentech, Inc., South San Francisco, California, USA., Tassew NG; Department of Safety Assessment Toxicology, Genentech, Inc., South San Francisco, California, USA., Sangaraju D; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA., O'Connor D; Department of Chemistry, Manufacturing, and Controls, Genentech, Inc., South San Francisco, California, USA., Hötzel I; Department of Antibody Engineering, Genentech, Inc., South San Francisco, California, USA., Stark KL; Department of Neuroscience, Genentech, Inc., South San Francisco, California, USA., Chou C; Department of Safety Assessment Nonclinical Operations, Genentech, Inc., South San Francisco, California, USA., Foreman O; Department of Research Pathology, Genentech, Inc., South San Francisco, California, USA., Easton A; Department of Neuroscience, Genentech, Inc., South San Francisco, California, USA., Wildsmith KR; Department of Translational Medicine, Genentech, Inc., South San Francisco, California, USA., Sperinde G; Department of BioAnalytical Sciences, Genentech, Inc., South San Francisco, California, USA., Rose CM; Department of Microchemistry, Proteomics, Lipidomics, and Next Generation Sequencing, Genentech, Inc., South San Francisco, California, USA., Friedman BA; Department of Bioinformatics, Genentech, Inc., South San Francisco, California, USA., Fuji RN; Department of Safety Assessment Pathology, Genentech, Inc., South San Francisco, California, USA., Weimer RM; Department of Translational Imaging, Genentech, Inc., South San Francisco, California, USA., Meilandt WJ; Department of Neuroscience, Genentech, Inc., South San Francisco, California, USA., Sadekar S; Department of Preclinical and Translational Pharmacokinetics and Pharmacodynamics, Genentech, Inc., South San Francisco, California, USA., Nugent AA; Department of Human Pathobiology and OMNI Reverse Translation, Genentech, Inc., South San Francisco, California, USA., Biever A; Department of Translational Medicine, Genentech, Inc., South San Francisco, California, USA.
Publikováno v:
Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Sep; Vol. 20 (9), pp. 5861-5888. Date of Electronic Publication: 2024 Aug 01.
Autor:
Etxeberria A; Departments of Neuroscience, Genentech, Inc., South San Francisco, California 94080., Shen YA; Departments of Neuroscience, Genentech, Inc., South San Francisco, California 94080., Vito S; Departments of Neuroscience, Genentech, Inc., South San Francisco, California 94080., Silverman SM; Departments of Neuroscience, Genentech, Inc., South San Francisco, California 94080., Imperio J; Departments of Neuroscience, Genentech, Inc., South San Francisco, California 94080., Lalehzadeh G; Departments of Neuroscience, Genentech, Inc., South San Francisco, California 94080., Soung AL; Departments of Neuroscience, Genentech, Inc., South San Francisco, California 94080., Du C; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California 94080., Xie L; Translational Imaging, Genentech, Inc., South San Francisco, California 94080., Choy MK; Translational Imaging, Genentech, Inc., South San Francisco, California 94080., Hsiao YC; Antibody Engineering, Genentech, Inc., South San Francisco, California 94080., Ngu H; Pathology, Genentech, Inc., South San Francisco, California 94080., Cho CH; Human Pathobiology and OMNI Reverse Translation, Genentech, Inc., South San Francisco, California 94080., Ghosh S; Departments of Neuroscience, Genentech, Inc., South San Francisco, California 94080., Novikova G; Bioinformatics, Genentech, Inc., South San Francisco, California 94080., Rezzonico MG; Bioinformatics, Genentech, Inc., South San Francisco, California 94080., Leahey R; Departments of Neuroscience, Genentech, Inc., South San Francisco, California 94080., Weber M; Departments of Neuroscience, Genentech, Inc., South San Francisco, California 94080., Gogineni A; Translational Imaging, Genentech, Inc., South San Francisco, California 94080., Elstrott J; Translational Imaging, Genentech, Inc., South San Francisco, California 94080., Xiong M; Departments of Neuroscience, Genentech, Inc., South San Francisco, California 94080., Greene JJ; Departments of Neuroscience, Genentech, Inc., South San Francisco, California 94080., Stark KL; Departments of Neuroscience, Genentech, Inc., South San Francisco, California 94080., Chan P; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California 94080., Roth GA; Preclinical and Translational Pharmacokinetics and Pharmacodynamics, Genentech, Inc., South San Francisco, California 94080., Adrian M; Pathology, Genentech, Inc., South San Francisco, California 94080., Li Q; Microchemistry Lipidomics and Proteomics, Genentech, Inc., South San Francisco, California 94080., Choi M; Microchemistry Lipidomics and Proteomics, Genentech, Inc., South San Francisco, California 94080., Wong WR; Microchemistry Lipidomics and Proteomics, Genentech, Inc., South San Francisco, California 94080., Sandoval W; Microchemistry Lipidomics and Proteomics, Genentech, Inc., South San Francisco, California 94080., Foreman O; Pathology, Genentech, Inc., South San Francisco, California 94080., Nugent AA; Human Pathobiology and OMNI Reverse Translation, Genentech, Inc., South San Francisco, California 94080., Friedman BA; Bioinformatics, Genentech, Inc., South San Francisco, California 94080., Sadekar S; Preclinical and Translational Pharmacokinetics and Pharmacodynamics, Genentech, Inc., South San Francisco, California 94080., Hötzel I; Antibody Engineering, Genentech, Inc., South San Francisco, California 94080., Hansen DV; Departments of Neuroscience, Genentech, Inc., South San Francisco, California 94080., Chih B; Departments of Neuroscience, Genentech, Inc., South San Francisco, California 94080.; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California 94080., Yuen TJ; Departments of Neuroscience, Genentech, Inc., South San Francisco, California 94080., Weimer RM; Translational Imaging, Genentech, Inc., South San Francisco, California 94080., Easton A; Departments of Neuroscience, Genentech, Inc., South San Francisco, California 94080., Meilandt WJ; Departments of Neuroscience, Genentech, Inc., South San Francisco, California 94080 bohlenc@gene.com williajm@gene.com., Bohlen CJ; Departments of Neuroscience, Genentech, Inc., South San Francisco, California 94080 bohlenc@gene.com williajm@gene.com.
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2024 Jul 17; Vol. 44 (29). Date of Electronic Publication: 2024 Jul 17.
Autor:
Dominguez SL; Department of Neuroscience, Genentech, South San Francisco, CA 94080, USA., Laufer BI; Department of Neuroscience, Genentech, South San Francisco, CA 94080, USA.; Department of OMNI Bioinformatics, Genentech, South San Francisco, CA 94080, USA., Ghosh AS; Department of Neuroscience, Genentech, South San Francisco, CA 94080, USA., Li Q; Department of Microchemistry, Proteomics, and Lipidomics, Genentech, South San Francisco, CA 94080, USA., Ruggeri G; Department of Biochemistry and Cellular Pharmacology, Genentech, South San Francisco, CA 94080, USA., Emani MR; Department of Neuroscience, Genentech, South San Francisco, CA 94080, USA.; Department of Biochemistry and Cellular Pharmacology, Genentech, South San Francisco, CA 94080, USA., Phu L; Department of Microchemistry, Proteomics, and Lipidomics, Genentech, South San Francisco, CA 94080, USA., Friedman BA; Department of Neuroscience, Genentech, South San Francisco, CA 94080, USA.; Department of OMNI Bioinformatics, Genentech, South San Francisco, CA 94080, USA., Sandoval W; Department of Microchemistry, Proteomics, and Lipidomics, Genentech, South San Francisco, CA 94080, USA., Rose CM; Department of Microchemistry, Proteomics, and Lipidomics, Genentech, South San Francisco, CA 94080, USA., Ngu H; Department of Pathology, Genentech, South San Francisco, CA 94080, USA., Foreman O; Department of Pathology, Genentech, South San Francisco, CA 94080, USA., Reichelt M; Department of Pathology, Genentech, South San Francisco, CA 94080, USA., Juste Y; Department of Neuroscience, Genentech, South San Francisco, CA 94080, USA., Lalehzadeh G; Department of Neuroscience, Genentech, South San Francisco, CA 94080, USA., Hansen D; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen, 2970 Hørsholm, DK, Denmark., Nymark H; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen, 2970 Hørsholm, DK, Denmark., Mellal D; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen, 2970 Hørsholm, DK, Denmark., Gylling H; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen, 2970 Hørsholm, DK, Denmark., Kiełpiński ŁJ; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen, 2970 Hørsholm, DK, Denmark., Chih B; Department of Neuroscience, Genentech, South San Francisco, CA 94080, USA.; Department of Biochemistry and Cellular Pharmacology, Genentech, South San Francisco, CA 94080, USA., Bingol B; Department of Neuroscience, Genentech, South San Francisco, CA 94080, USA., Hoogenraad CC; Department of Neuroscience, Genentech, South San Francisco, CA 94080, USA., Meilandt WJ; Department of Neuroscience, Genentech, South San Francisco, CA 94080, USA., Easton A; Department of Neuroscience, Genentech, South San Francisco, CA 94080, USA.
Publikováno v:
IScience [iScience] 2023 Oct 29; Vol. 26 (11), pp. 108362. Date of Electronic Publication: 2023 Oct 29 (Print Publication: 2023).
Autor:
Adrian M; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA.; Department of Pathology, Genentech, Inc., South San Francisco, CA, 94080, USA., Weber M; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA., Tsai MC; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA., Glock C; Department of OMNI Bioinformatics, Genentech Inc., South San Francisco, CA, 94080, USA., Kahn OI; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA., Phu L; Department of Microchemistry, Proteomics and Lipidomics, South San Francisco, CA, 94080, USA., Cheung TK; Department of Microchemistry, Proteomics and Lipidomics, South San Francisco, CA, 94080, USA., Meilandt WJ; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA., Rose CM; Department of Microchemistry, Proteomics and Lipidomics, South San Francisco, CA, 94080, USA., Hoogenraad CC; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, 94080, USA. hoogenraad.casper@gene.com.
Publikováno v:
Nature communications [Nat Commun] 2023 Oct 09; Vol. 14 (1), pp. 6322. Date of Electronic Publication: 2023 Oct 09.
Autor:
Zeng H; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Huang J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Zhou H; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Meilandt WJ; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, USA., Dejanovic B; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zhou Y; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Bohlen CJ; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, USA., Lee SH; Department of Neuroscience, Genentech, Inc., South San Francisco, CA, USA., Ren J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Liu A; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Tang Z; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Sheng H; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA., Liu J; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA., Sheng M; Broad Institute of MIT and Harvard, Cambridge, MA, USA. msheng@broadinstitute.org.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. msheng@broadinstitute.org.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. msheng@broadinstitute.org., Wang X; Broad Institute of MIT and Harvard, Cambridge, MA, USA. wangxiao@broadinstitute.org.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. wangxiao@broadinstitute.org.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. wangxiao@broadinstitute.org.
Publikováno v:
Nature neuroscience [Nat Neurosci] 2023 Mar; Vol. 26 (3), pp. 430-446. Date of Electronic Publication: 2023 Feb 02.
Autor:
Sadekar SS; Genentech Research and Early Development, Genentech, Inc., a Member of the Roche Group, San Francisco, California, USA., Bowen M; Pharma Technical Development, Genentech, Inc., a Member of the Roche Group, San Francisco, California, USA., Cai H; Genentech Research and Early Development, Genentech, Inc., a Member of the Roche Group, San Francisco, California, USA., Jamalian S; Genentech Research and Early Development, Genentech, Inc., a Member of the Roche Group, San Francisco, California, USA., Rafidi H; Genentech Research and Early Development, Genentech, Inc., a Member of the Roche Group, San Francisco, California, USA., Shatz-Binder W; Genentech Research and Early Development, Genentech, Inc., a Member of the Roche Group, San Francisco, California, USA., Lafrance-Vanasse J; Genentech Research and Early Development, Genentech, Inc., a Member of the Roche Group, San Francisco, California, USA., Chan P; Genentech Research and Early Development, Genentech, Inc., a Member of the Roche Group, San Francisco, California, USA., Meilandt WJ; Genentech Research and Early Development, Genentech, Inc., a Member of the Roche Group, San Francisco, California, USA., Oldendorp A; Genentech Research and Early Development, Genentech, Inc., a Member of the Roche Group, San Francisco, California, USA., Sreedhara A; Pharma Technical Development, Genentech, Inc., a Member of the Roche Group, San Francisco, California, USA., Daugherty A; Pharma Technical Development, Genentech, Inc., a Member of the Roche Group, San Francisco, California, USA., Crowell S; Genentech Research and Early Development, Genentech, Inc., a Member of the Roche Group, San Francisco, California, USA., Wildsmith KR; Clinical Pharmacology and Translational Medicine, Neurology Business, Eisai, Nutley, New Jersey, USA., Atwal J; Genentech Research and Early Development, Genentech, Inc., a Member of the Roche Group, San Francisco, California, USA., Fuji RN; Genentech Research and Early Development, Genentech, Inc., a Member of the Roche Group, San Francisco, California, USA., Horvath J; Pharma Technical Development, Genentech, Inc., a Member of the Roche Group, San Francisco, California, USA.
Publikováno v:
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2022 Apr; Vol. 111 (4), pp. 826-834. Date of Electronic Publication: 2022 Feb 23.