Výsledky vyhledávání - "Meike Spiekermann"

The expression of miRNA encoded by C19MC and miR-371-3 strongly varies among individual placentas but does not differ between spontaneous and induced abortions

Autor: Lars Burchardt, Inga Flor, Rolf Nimzyk, Meike Spiekermann, Jörn Bullerdiek, Susanne Feidicker, Marc Langenbuch, Andrea Gottlieb, Burkhard Helmke

Publikováno v: Protoplasma

miRNAs of the largest human miRNA gene cluster at all, i.e., C19MC, are almost exclusively expressed in the placenta. Nevertheless, only little is known about the interindividual variation of their expression and even about possible influence of gest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717e4afd4f44e84d2af67fde19935290
https://doi.org/10.1007/s00709-020-01548-3

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MicroRNA miR-371a-3p in serum of patients with germ cell tumours: evaluations for establishing a serum biomarker

Autor: Thomas Balks, Gazanfer Belge, Raphael Ikogho, Nina Winter, Jörn Bullerdiek, Meike Spiekermann, Klaus-Peter Dieckmann

Publikováno v: Andrology. 3:78-84

Summary As only 60% of the patients with germ cell tumour (GCT) express the classical markers, new markers as for example microRNAs (miRNAs) are required. One promising candidate is miR-371a-3p, but data are sparse to date. We measured serum levels o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6956435151f127c03d610a0989da20b
https://doi.org/10.1111/j.2047-2927.2014.00269.x

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Serum Levels of MicroRNA miR-371a-3p: A Sensitive and Specific New Biomarker for Germ Cell Tumours

Autor: Werner Wosniok, Cord Matthies, Arlo Radtke, Meike Spiekermann, Christoph Oing, Gazanfer Belge, Thomas Balks, Sebastian Melchior, Johannes Hammel, Klaus-Peter Dieckmann, Karin Oechsle, Christian Ruf, Carsten Bokemeyer, Pascal Becker

Publikováno v: European urology. 71(2)

Background Clinical management of germ cell tumours (GCTs) relies on monitoring of serum tumour markers. However, the markers α-fetoprotein (AFP), the β-subunit of human chorionic gonadotropin (bHCG), and lactate dehydrogenase (LDH) are expressed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c89386b276c1fbb67d58dc18c98c54
https://pubmed.ncbi.nlm.nih.gov/28209431

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Expression of microRNAs of C19MC in Different Histological Types of Testicular Germ Cell Tumour

Autor: Inga, Flor, Meike, Spiekermann, Thomas, Löning, Klaus-Peter, Dieckmann, Gazanfer, Belge, Jörn, Bullerdiek

Publikováno v: Cancer genomicsproteomics. 13(4)

Testicular germ cell tumours (TGCTs) are the most common tumours in men aged from 20 to 40 years, with a steadily increasing incidence. This study aimed to characterize the expression of the miRNA cluster C19MC in TGCT and to evaluate the suitability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f3a71dd7e437863034f186bebc77f6e6
https://pubmed.ncbi.nlm.nih.gov/28208526

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MicroRNAs miR-371-3 in serum as diagnostic tools in the management of testicular germ cell tumours

Autor: Thomas Balks, Gazanfer Belge, Jörn Bullerdiek, Meike Spiekermann, Thomas Löning, Klaus-Peter Dieckmann, Inga Flor

Publikováno v: British Journal of Cancer

Background: miRNAs are small noncoding RNA molecules that can be released into body fluids. Germ cell tumours (GCTs) overexpress miRNAs of the miR-371-3 cluster. Thus, serum levels of these miRNAs may correlate with tumour load. Methods: miRNAs of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235861efb714eacfefe7646f74a2881e
http://europepmc.org/articles/PMC3493876

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MicroRNA miR-371a-3p - A Novel Serum Biomarker of Testicular Germ Cell Tumors: Evidence for Specificity from Measurements in Testicular Vein Blood and in Neoplastic Hydrocele Fluid

Autor: Petra Anheuser, Thomas Loening, Werner Wosniok, Thomas Balks, Klaus-Peter Dieckmann, Raphael Ikogho, Gazanfer Belge, Jörn Bullerdiek, Meike Spiekermann

Publikováno v: Urologia internationalis. 97(1)

Background: microRNAs (miRs)-371-3 are suggested to be novel biomarkers of germ cell tumors (GCTs), but their specificity is unresolved. We aimed at clarifying the origin of miR 371a-3p by measuring this miR in peripheral vein blood, and in fluids pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74f904c65e08aae5a38d935d815b1ab
https://pubmed.ncbi.nlm.nih.gov/29677902

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Is relative quantification dispensable for the measurement of microRNAs as serum biomarkers in germ cell tumors?

Autor: Meike, Spiekermann, Klaus-Peter, Dieckmann, Thomas, Balks, Jörn, Bullerdiek, Gazanfer, Belge

Publikováno v: Anticancer research. 35(1)

Classical biomarkers α-fetoprotein, β-human chorionic gonadotropin and lactate dehydrogenase (AFP, bHCG and LDH) are elevated in only 60% of all testicular germ cell tumor (TGCT) patients. microRNAs (miRNAs) are a novel class of useful biomarkers i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f06ad538377391dc24cea30753b1b15d
https://pubmed.ncbi.nlm.nih.gov/25550541

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Is measuring serum levels of microRNA miR-371a-3p superior to the classical biomarkers of testicular germ cell tumors?

Autor: Karin Oechsle, Klaus-Peter Dieckmann, Gazanfer Belge, Christian Ruf, Meike Spiekermann

Publikováno v: Journal of Clinical Oncology. 33:376-376

376 Background: There is need for more serum biomarkers of testicular germ cell tumors (GCTs) because the management of GCT is largely based on marker monitoring but only 60% of patients express the classical markers AFP and beta HCG. We measured ser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82583406d5a78d56fe277e5a01b1c22f
https://doi.org/10.1200/jco.2015.33.7_suppl.376

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