Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Meike Schwarz"'
Autor:
Katrin Fink, Hans-Jörg Busch, Natascha Bourgeois, Meike Schwarz, Dennis Wolf, Andreas Zirlik, Karlheinz Peter, Christoph Bode, Constantin von Zur Muhlen
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e53103 (2013)
OBJECTIVE: The endothelial protein C-receptor (EPCR) is an endothelial transmembrane protein that binds protein C and activated protein C (APC) with equal affinity, thereby facilitating APC formation. APC has anticoagulant, antiapoptotic and antiinfl
Externí odkaz:
https://doaj.org/article/ca8c2e1584b2418c91653ae439a3f9ee
Autor:
Constantin von zur Mühlen, Dominik von Elverfeldt, Robin Paul Choudhury, Janine Ender, Ingo Ahrens, Meike Schwarz, Jürgen Hennig, Christoph Bode, Karlheinz Peter
Publikováno v:
Molecular Imaging, Vol 7 (2008)
Recent progress in molecular magnetic resonance imaging (MRI) provides the opportunity to image cells and cellular receptors using microparticles of iron oxide (MPIOs). However, imaging targets on vessel walls remains challenging owing to the quantit
Externí odkaz:
https://doaj.org/article/25b54783db2f4d37ac1ff87e0d57c097
Publikováno v:
Intensivmedizin up2date. 5:37-44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f1f6a897df914fa5b3a39bdfc279c9e
https://doi.org/10.1055/s-2008-1077462
https://doi.org/10.1055/s-2008-1077462
Autor:
Karlheinz Peter, Robin P. Choudhury, J.A. Moeller, Christoph E. Hagemeyer, Manfred Olschewski, Nicole Bassler, A. K. Becker, Meike Schwarz, Irene Neudorfer, Dominik Paul, Christoph Bode, C. von zur Muhlen, D. von Elverfeldt
Publikováno v:
Circulation. 118:258-267
Background— Platelets are the key to thrombus formation and play a role in the development of atherosclerosis. Noninvasive imaging of activated platelets would be of great clinical interest. Here, we evaluate the ability of a magnetic resonance ima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812824bef38d95d3ce5066c9da349c6c
https://doi.org/10.1161/circulationaha.107.753657
https://doi.org/10.1161/circulationaha.107.753657
Publikováno v:
Nature Protocols. 2:3063-3073
Phage-display of antibody libraries is a powerful tool to select antibodies for specific epitopes. We describe a strategy for selecting highly specific scFv-clones that discriminate between various conformational states of cell surface receptors. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9cf46d0edfb076fa9055c48e9071f78
https://doi.org/10.1038/nprot.2007.455
https://doi.org/10.1038/nprot.2007.455
Autor:
Meike Schwarz, Karlheinz Peter, Benedikt H. J. Pannen, Christoph Bode, Yasuhiro Katagiri, Ingo Ahrens, Yung-Chih Chen, Christoph E. Hagemeyer, Steffen U. Eisenhardt, Patrick Stoll, Rene Schmidt, Nicole Bassler
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 27:1206-1212
Objective—Therapeutic anticoagulation is widely used, but limitations in efficacy and bleeding complications cause an ongoing search for new agents. However, with new agents developed it seems to be an inherent problem that increased efficiency is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a82b18dc1f25e5fb6a30cbb8e6522a
https://doi.org/10.1161/atvbaha.106.138875
https://doi.org/10.1161/atvbaha.106.138875
Publikováno v:
Seminars in Thrombosis and Hemostasis. 33:185-195
Antibodies are the most rapidly growing class of human therapeutics and the second largest class of drugs after vaccines. At present, several antibodies are approved for therapeutic use in diverse clinical settings, including oncology, chronic inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d12e6c24a01a248ae481d05d124d11
https://doi.org/10.1055/s-2007-969033
https://doi.org/10.1055/s-2007-969033
Publikováno v:
Transfusion Medicine and Hemotherapy. 34:44-54
A variety of orally and intravenously administered agents have been made available for anti-platelet therapy. Clinical trials in patients with acute manifestations of cardiovascular disease have sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7b0149ad5a4cb33d66c819005258145
https://doi.org/10.1159/000097664
https://doi.org/10.1159/000097664
Autor:
Karlheinz Peter, Christoph Loeffler, Christoph Bode, Nicole Bassler, Yasuhiro Katagiri, Meike Schwarz, Masaharu Kotani
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 308:1002-1011
Clinically used GPIIb/IIIa blockers are ligand mimetics, and thereby their binding can induce conformational changes of the platelet integrin GPIIb/IIIa. Since the reversibility of these conformational changes may be an important determinant of poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3432b8db0cdb58f73a262da3a62dcac2
https://doi.org/10.1124/jpet.103.058883
https://doi.org/10.1124/jpet.103.058883
Publikováno v:
Thrombosis Research. 107:121-128
Cross-reactivity with integrins other than glycoprotein IIb/IIIa (GP IIb/IIIa) is discussed as a potential reason for the overall clinical benefits of the GP IIb/IIIa-blocking antibody-fragment abciximab. We evaluated whether abciximab binds to the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a8fccf8cd393750579dbb821c999be
https://doi.org/10.1016/s0049-3848(02)00207-4
https://doi.org/10.1016/s0049-3848(02)00207-4