Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Meike Hutt"'
Autor:
Stefan Krämer, Andreas Moritz, Luca Stehl, Meike Hutt, Martin Hofmann, Claudia Wagner, Sebastian Bunk, Dominik Maurer, Günter Roth, Johannes Wöhrle
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Peptide human leukocyte antigen (pHLA) targeting therapeutics like T-cell receptor based adoptive cell therapy or bispecific T cell engaging receptor molecules hold great promise for the treatment of cancer. Comprehensive pre-clinical screen
Externí odkaz:
https://doaj.org/article/98b1712f69d047b39549cb05a8e59194
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Mesenchymal stem cells (MSCs) are currently exploited as gene delivery systems for transient in situ expression of cancer therapeutics. As an alternative to the prevailing viral expression, we here describe a murine MSC line stably expressing a thera
Externí odkaz:
https://doaj.org/article/fbc4ae67d7e64509a170bd80e8ce27ef
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139838 (2015)
Half-life extension strategies have gained increasing interest to improve the pharmacokinetic and pharmacodynamic properties of protein therapeutics. Recently, we established an immunoglobulin-binding domain (IgBD) from streptococcal protein G (SpGC3
Externí odkaz:
https://doaj.org/article/fca76b27d5204ce980fe47c1c1aa865d
Autor:
Roland E. Kontermann, Klaus Pfizenmaier, Dagmar Kulms, Ines Müller, Martin Siegemund, Oliver Seifert, Lisa Marquardt, Meike Hutt
Figure S6 provides data on biochemical and functional characterization of Fc-scTRAIL8M.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400bd3f23d0b0cb556d092cb9342712e
https://doi.org/10.1158/1535-7163.22503223.v1
https://doi.org/10.1158/1535-7163.22503223.v1
Autor:
Roland E. Kontermann, Klaus Pfizenmaier, Dagmar Kulms, Ines Müller, Martin Siegemund, Oliver Seifert, Lisa Marquardt, Meike Hutt
Figure S7 provides data on safety of the treatments with EGFR-targeted scTRAIL fusion proteins and Fc-scTRAIL in combination with bortezomib.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b323e9a08eaaa3688f73b393e377651
https://doi.org/10.1158/1535-7163.22503205
https://doi.org/10.1158/1535-7163.22503205
Autor:
Roland E. Kontermann, Klaus Pfizenmaier, Dagmar Kulms, Ines Müller, Martin Siegemund, Oliver Seifert, Lisa Marquardt, Meike Hutt
Table S1 provides data on biochemical properties of the scTRAIL molecules, Table S2 provides data on binding properties of the scTRAIL molecules, Table 3 provides data on the EC50 values of cell death induction of the scTRAIL molecules in the presenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19023cc347f07321e451b7763dc86504
https://doi.org/10.1158/1535-7163.22503202.v1
https://doi.org/10.1158/1535-7163.22503202.v1
Autor:
Sebastian Bunk, Martin Hofmann, Gabriele Pszolla, Meike Hutt, Felix Unverdorben, Frank Schwoebel, Nadine Aschmoneit, Claudia Wagner, Maike Jaworski, Christoph Schraeder, Heiko Schuster, Sarah Missel, Toni Weinschenk, Dominik Maurer, Carsten Reinhardt
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34190b24ee76bd453e47e8de8297bc7a
https://doi.org/10.1136/jitc-2022-sitc2022.1319
https://doi.org/10.1136/jitc-2022-sitc2022.1319
Autor:
Gloria B. Kim, Jens Fritsche, Sebastian Bunk, Andrea Mahr, Felix Unverdorben, Kevin Tosh, Hong Kong, Colby R. Maldini, Chui Lau, Sriram Srivatsa, Shuguang Jiang, Joshua Glover, Derek Dopkin, Carolyn X. Zhang, Heiko Schuster, Daniel J. Kowalewski, Valentina Goldfinger, Martina Ott, David Fuhrmann, Maike Baues, Hans Boesmueller, Christoph Schraeder, Gisela Schimmack, Colette Song, Franziska Hoffgaard, Michael Roemer, Chih-Chiang Tsou, Martin Hofmann, Thomas Treiber, Meike Hutt, Leonie Alten, Maike Jaworski, Amir Alpert, Sarah Missel, Carsten Reinhardt, Harpreet Singh, Oliver Schoor, Steffen Walter, Claudia Wagner, Dominik Maurer, Toni Weinschenk, James L. Riley
Publikováno v:
Sci Transl Med
T cell receptor (TCR)–based immunotherapy has emerged as a promising therapeutic approach for the treatment of patients with solid cancers. Identifying peptide–human leukocyte antigen (pHLA) complexes highly presented on tumors and rarely express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f6e898b6a4776378ef2a9476f7dac1
https://pubmed.ncbi.nlm.nih.gov/36516272
https://pubmed.ncbi.nlm.nih.gov/36516272
Autor:
Sebastian Bunk, Martin Hofmann, Gabriele Pszolla, Meike Hutt, Frank Schwöbel, Felix Unverdorben, Nadine Aschmoneit, Claudia Wagner, Maike Jaworski, Heiko Schuster, Florian Schwoerer, Christoph Schraeder, Oliver Schoor, Sarah Missel, Toni Weinschenk, Dominik Maurer, Carsten Reinhardt
Publikováno v:
Blood. 140:9089-9090
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7740dec0d52b05e6090141f4e02d38f2
https://doi.org/10.1182/blood-2022-165937
https://doi.org/10.1182/blood-2022-165937
Autor:
Meike Hutt, Dagmar Kulms, Oliver Seifert, Markus Rehm, Christian Praetorius, Vesna Vetma, Friedegund Meier, Roland E. Kontermann, Nathalie Peters, Cristiano Guttà
Publikováno v:
Cell Death and Differentiation
Second generation TRAIL-based therapeutics, combined with sensitising co-treatments, have recently entered clinical trials. However, reliable response predictors for optimal patient selection are not yet available. Here, we demonstrate that a novel a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b22d077dd01505289eb3f325d4eba3
https://doi.org/10.1038/s41418-020-0512-5
https://doi.org/10.1038/s41418-020-0512-5