Výsledky vyhledávání

Akademický článek

Yeast gene KTI13 (alias DPH8) operates in the initiation step of diphthamide synthesis on elongation factor 2

Autor: Meike Arend, Koray Ütkür, Harmen Hawer, Klaus Mayer, Namit Ranjan, Lorenz Adrian, Ulrich Brinkmann, Raffael Schaffrath

Publikováno v: Microbial Cell, Vol 10, Iss 9, Pp 195-203 (2022)

In yeast, Elongator-dependent tRNA modifications are regulated by the Kti11•Kti13 dimer and hijacked for cell killing by zymocin, a tRNase ribotoxin. Kti11 (alias Dph3) also controls modification of elongation factor 2 (EF2) with diphthamide, the t

Externí odkaz: https://doaj.org/article/cbab6fc1de5a40b2b53aba41197cf186

Zobrazit plný text záznamu

Akademický článek

Importance of diphthamide modified EF2 for translational accuracy and competitive cell growth in yeast.

Autor: Harmen Hawer, Koray Ütkür, Meike Arend, Klaus Mayer, Lorenz Adrian, Ulrich Brinkmann, Raffael Schaffrath

Publikováno v: PLoS ONE, Vol 13, Iss 10, p e0205870 (2018)

In eukaryotes, the modification of an invariant histidine (His-699 in yeast) residue in translation elongation factor 2 (EF2) with diphthamide involves a conserved pathway encoded by the DPH1-DPH7 gene network. Diphthamide is the target for diphtheri

Externí odkaz: https://doaj.org/article/8929e9a8a466449f9184002f6ad44762

Zobrazit plný text záznamu

Plný text ve formátu HTML