Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Amiodarone Toxicity

Autor: Bețiu, Alina M., Chamkha, Imen, Gustafsson, Ellen, Meijer, Elna, Avram, Vlad F., Frostner, Eleonor Åsander, Ehinger, Johannes K., Petrescu, Lucian, Muntean, Danina M., Elmér, Eskil

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 11786, p 11786 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 21

Amiodarone is a potent antiarrhythmic drug and displays substantial liver toxicity in humans. It has previously been demonstrated that amiodarone and its metabolite (desethylamiodarone, DEA) can inhibit mitochondrial function, particularly complexes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::70022de903b9a9676ea5bdd845d19f12
https://pubmed.ncbi.nlm.nih.gov/34769217