Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Meihua Han"'
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 117107- (2024)
The development of new effective drugs to treat breast cancer remains a huge challenge. ABT-737 can inhibit Bcl-2 proteins to promote apoptosis. Resiquimod (R848) is a TLR7/8 agonist that is effective in modulating the immunosuppressive microenvironm
Externí odkaz:
https://doaj.org/article/dd477b2f98654b039035d09e95bc7568
Publikováno v:
Drug Delivery, Vol 29, Iss 1, Pp 2539-2548 (2022)
Oleic acid (OA) is a kind of monounsaturated omega-3 fatty acid that abounds in plants and animals which can induce apoptosis and has broad-spectrum inhibitory activity against a variety of tumor cell lines. However, OA is quite insoluble and thus in
Externí odkaz:
https://doaj.org/article/7ce701010e1e4dff996ec703ef11313e
Autor:
Likang Lu, Hui Ao, Jingxin Fu, Manzhen Li, Yaoyao Guo, Yifei Guo, Meihua Han, Rongxing Shi, Xiangtao Wang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 163, Iss , Pp 114870- (2023)
Ginsenosides are the major and key components for ginseng to exert its wide and beneficial therapeutic efficacy in clinic. Meanwhile, many ginsenosides and their metabolites showed in vitro an in vivo anti-tumor activity, among which ginsenoside Rb1
Externí odkaz:
https://doaj.org/article/c5b66139c3f543ada6f7f373cd80b53e
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 162, Iss , Pp 114662- (2023)
Drug delivery systems require that carrier materials have good biocompatibility, degradability, and constructability. Poly(amino acids), a substance with a distinctive secondary structure, not only have the basic features of the carrier materials but
Externí odkaz:
https://doaj.org/article/735474f3888246bfa6ab1ee85f3fceb0
Autor:
Hui Ao, Zhuo Wang, Likang Lu, Hongwei Ma, Haowen Li, Jingxin Fu, Manzhen Li, Meihua Han, Yifei Guo, Xiangtao Wang
Publikováno v:
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-14 (2022)
Abstract Background Most intravenously administered drug-loaded nanoparticles are taken up by liver Kupffer cells, and only a small portion can accumulate at the tumor, resulting in an unsatisfactory therapeutic efficacy and side effects for chemothe
Externí odkaz:
https://doaj.org/article/1865932036184b47ad942349f0dff453
Publikováno v:
Toxins, Vol 15, Iss 9, p 565 (2023)
Ochratoxins are the secondary metabolites of Penicillium and Aspergillus, among which ochratoxin A (OTA) is the most toxic molecule. OTA is widely found in food and agricultural products. Due to its severe nephrotoxicity, immunotoxicity, neurotoxicit
Externí odkaz:
https://doaj.org/article/d3d29bcd340a435388ef03ba140c0e62
Autor:
Changzhi Shi, Jelisaveta Ignjatović, Tingting Liu, Meihua Han, Dongmei Cun, Jelena Đuriš, Mingshi Yang, Sandra Cvijić
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 16, Iss 3, Pp 350-362 (2021)
This study aims to understand the absorption patterns of three different kinds of inhaled formulations via in silico modeling using budesonide (BUD) as a model drug. The formulations investigated in this study are: (i) commercially available microniz
Externí odkaz:
https://doaj.org/article/5b6a4605693e409fa775b852e5033a50
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1335 (2023)
Neutral/negatively charged nanoparticles are beneficial to reduce plasma protein adsorption and prolong their blood circulation time, while positively charged nanoparticles easily transverse the blood vessel endothelium into a tumor and easily penetr
Externí odkaz:
https://doaj.org/article/80983b04a616492ca73713cb4cc82e84
Autor:
Hui Ao, Yijing Li, Haowen Li, Yian Wang, Meihua Han, Yifei Guo, Rongxing Shi, Feng Yue, Xiangtao Wang
Publikováno v:
Drug Delivery, Vol 27, Iss 1, Pp 816-824 (2020)
Hydroxy genkwanin (HGK), a flavonoid compound from natural resources, showed good inhibition against the growth of breast tumor cells. However, the poor solubility restricted the further study and the in vivo drug delivery of HGK. We prepared HGK nan
Externí odkaz:
https://doaj.org/article/d5f502701ef14f48bb9a78f91aaaf68a
Autor:
Yian Wang, Tiantian Huang, Haowen Li, Jingxin Fu, Hui Ao, Likang Lu, Meihua Han, Yifei Guo, Feng Yue, Xiangtao Wang
Publikováno v:
Drug Delivery, Vol 27, Iss 1, Pp 228-237 (2020)
Due to their various biological activities that are beneficial to human health and antitumor effect, flavonoid compounds have attracted much attention in recent years. Hydrous icaritin (HICT) was such a flavonoid that can inhibit the growth of breast
Externí odkaz:
https://doaj.org/article/eb671a5223194b278ebc7d3e679c7e19