Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Meihua Tu"'
Publikováno v:
Letters in Drug Design & Discovery. 20:1372-1379
Background: Epoxide hydrolases comprise an important class of enzymes that have critical functions in the detoxification of xenobiotics and regulation of signaling molecules. In addition to epoxides, oxetanes have recently been identified as novel su
Autor:
Francis Rajamohan, Allan R. Reyes, Meihua Tu, Nicole L. Nedoma, Lise R. Hoth, Adam G. Schwaid, Ravi G. Kurumbail, Jessica Ward, Seungil Han
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 8, Pp 1192-1202 (2020)
Lysosomal acid lipase (LAL) is a serine hydrolase that hydrolyzes cholesteryl ester (CE) and TGs delivered to the lysosomes into free cholesterol and fatty acids. LAL deficiency due to mutations in the LAL gene (LIPA) results in accumulation of TGs a
Externí odkaz:
https://doaj.org/article/84d1fdf5b7d8464b8ffe5b0c44285c5e
Autor:
Thomas J. McCorvie, Paula M. Loria, Meihua Tu, Seungil Han, Leela Shrestha, D. Sean Froese, Igor M. Ferreira, Allison P. Berg, Wyatt W. Yue
Publikováno v:
Nature Structural & Molecular Biology. 29:628-638
Glycogen synthase (GYS1) is the central enzyme in muscle glycogen biosynthesis. GYS1 activity is inhibited by phosphorylation of its amino (N) and carboxyl (C) termini, which is relieved by allosteric activation of glucose-6-phosphate (Glc6P). We pre
Autor:
Brajesh K. Rai, Vishnu Sresht, Qingyi Yang, Ray Unwalla, Meihua Tu, Alan M. Mathiowetz, Gregory A. Bakken
Publikováno v:
Journal of Chemical Information and Modeling. 62:785-800
Fast and accurate assessment of small-molecule dihedral energetics is crucial for molecular design and optimization in medicinal chemistry. Yet, accurate prediction of torsion energy profiles remains challenging as the current molecular mechanics (MM
Autor:
Adam G. Schwaid, Jessica Ward, Nicole L. Nedoma, Lise R. Hoth, Meihua Tu, Ravi G. Kurumbail, Seungil Han, Allan R. Reyes, Francis Rajamohan
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 8, Pp 1192-1202 (2020)
Journal of Lipid Research
Journal of Lipid Research
Lysosomal acid lipase (LAL) is a serine hydrolase that hydrolyzes cholesteryl ester (CE) and TGs delivered to the lysosomes into free cholesterol and fatty acids. LAL deficiency due to mutations in the LAL gene (LIPA) results in accumulation of TGs a
Autor:
Omar L. Francone, Meihua Tu, Lori J. Royer, Jian Zhu, Kimberly Stevens, Joseph J. Oleynek, Zhiwu Lin, Lorraine Shelley, Thomas Sand, Yi Luo, Christopher D. Kane
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 3, Pp 546-555 (2009)
Lectin-like oxidized LDL (ox-LDL) receptor-1 (LOX-1) is a type-II transmembrane protein that belongs to the C-type lectin family of molecules. LOX-1 acts as a cell surface endocytosis receptor and mediates the recognition and internalization of ox-LD
Externí odkaz:
https://doaj.org/article/15d6239d33c843fdaad050cff75c573f
Autor:
Thomas J, McCorvie, Paula M, Loria, Meihua, Tu, Seungil, Han, Leela, Shrestha, D Sean, Froese, Igor M, Ferreira, Allison P, Berg, Wyatt W, Yue
Publikováno v:
Nature structuralmolecular biology. 29(7)
Glycogen synthase (GYS1) is the central enzyme in muscle glycogen biosynthesis. GYS1 activity is inhibited by phosphorylation of its amino (N) and carboxyl (C) termini, which is relieved by allosteric activation of glucose-6-phosphate (Glc6P). We pre
Autor:
Meihua Tu, Alan M. Mathiowetz, Qingyi Yang, Gregory A. Bakken, Vishnu Sresht, Rayomond J. Unwalla, Brajesh K. Rai
TorsionNet: A Deep Neural Network to Rapidly Predict Small Molecule Torsion Energy Profiles with the Accuracy of Quantum Mechanics Brajesh K. Rai*,1, Vishnu Sresht1, Qingyi Yang2, Ray Unwalla2, Meihua Tu2, Alan M. Mathiowetz2, and Gregory A. Bakken3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b7ee673abd4b89ef76942ba7d2dfef
https://doi.org/10.26434/chemrxiv.13483185.v1
https://doi.org/10.26434/chemrxiv.13483185.v1
Autor:
Gang Xing, David Price, Aaron C. Smith, Jayasankar Jasti, Kentaro Futatsugi, Steven B. Coffey, Meihua Tu, Kevin D. Parris, Yan Weng, Dilinie P. Fernando, Kay Ahn, Matthew S. Dowling, Kim Huard, Jayvardhan Pandit, Jeffrey A. Pfefferkorn, Benjamin A. Thuma, Brian Raymer, Tim F. Ryder, Gregory J. Tesz, Andre Shavnya, Amit S. Kalgutkar, Jun Zhou, Hanna M. Wisniewska, Jemy A. Gutierrez, John D. Knafels, Magee Thomas Victor, Ingrid A. Stock, Sylvie Perez, Tsai Andy
Publikováno v:
Journal of medicinal chemistry. 63(22)
Increased fructose consumption and its subsequent metabolism have been implicated in metabolic disorders such as nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH) and insulin resistance. Ketohexokinase (KHK) converts fructose to fruct
Publikováno v:
J Chem Inf Model
Current drug discovery is expensive and time-consuming. It remains a challenging task to create a wide variety of novel compounds that not only have desirable pharmacological properties but also are cheaply available to low-income people. In this wor