Stratified analysis identifies HIF-2 α as a therapeutic target for highly immune-infiltrated melanomas.

Autor: Huang AY; Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Massachusetts Institute of Technology, Cambridge, USA., Burke KP; Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Porter R; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Meiger L; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Fatouros P; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Yang J; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Massachusetts Institute of Technology, Cambridge, USA.; Rutgers University, New Brunswick, NJ, USA., Robitschek E; Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Vokes N; University of Texas MD Anderson Cancer Center, Houston, USA., Ricker C; Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Rosado V; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Tarantino G; Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Chen J; Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Aprati TJ; Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Glettig MC; Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; ETH Zürich, Zurich, Switzerland., He Y; Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Wang C; Massachusetts Institute of Technology, Cambridge, USA., Fu D; Massachusetts Institute of Technology, Cambridge, USA., Ho LL; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Massachusetts Institute of Technology, Cambridge, USA., Galani K; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Massachusetts Institute of Technology, Cambridge, USA., Freeman GJ; Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Buchbinder EI; Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Stephen Hodi F; Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Kellis M; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Massachusetts Institute of Technology, Cambridge, USA., Boland GM; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Massachusetts General Hospital, Boston, MA, USA., Sharpe AH; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Liu D; Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 30. Date of Electronic Publication: 2024 Oct 30.