Neutralizing the Impact of the Virulence Factor LecA from Pseudomonas aeruginosa on Human Cells with New Glycomimetic Inhibitors.

Autor: Zahorska E; Chemical Biology of Carbohydrates (CBCH), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, 66123, Saarbrücken, Germany.; Department of Chemistry, Saarland University, 66123, Saarbrücken, Germany.; Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-, Braunschweig, Germany., Rosato F; Faculty of Biology, University of Freiburg, 79104, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104, Freiburg, Germany., Stober K; Faculty of Biology, University of Freiburg, 79104, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104, Freiburg, Germany., Kuhaudomlarp S; Université Grenoble Alpes, CNRS, CERMAV, 38000, Grenoble, France.; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.; Center for Excellence in Protein and Enzyme Technology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand., Meiers J; Chemical Biology of Carbohydrates (CBCH), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, 66123, Saarbrücken, Germany.; Department of Chemistry, Saarland University, 66123, Saarbrücken, Germany.; Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-, Braunschweig, Germany., Hauck D; Chemical Biology of Carbohydrates (CBCH), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, 66123, Saarbrücken, Germany.; Department of Chemistry, Saarland University, 66123, Saarbrücken, Germany.; Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-, Braunschweig, Germany., Reith D; Faculty of Biology, University of Freiburg, 79104, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104, Freiburg, Germany., Gillon E; Université Grenoble Alpes, CNRS, CERMAV, 38000, Grenoble, France., Rox K; Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-, Braunschweig, Germany.; Department of Chemical Biology (CBIO), Helmholtz Centre for Infection Research (HZI), 38124, Braunschweig, Germany., Imberty A; Université Grenoble Alpes, CNRS, CERMAV, 38000, Grenoble, France., Römer W; Faculty of Biology, University of Freiburg, 79104, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104, Freiburg, Germany.; Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, 79104, Freiburg, Germany., Titz A; Chemical Biology of Carbohydrates (CBCH), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, 66123, Saarbrücken, Germany.; Department of Chemistry, Saarland University, 66123, Saarbrücken, Germany.; Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-, Braunschweig, Germany.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2023 Feb 06; Vol. 62 (7), pp. e202215535. Date of Electronic Publication: 2023 Jan 10.

Lectin-Targeted Prodrugs Activated by Pseudomonas aeruginosa for Self-Destructive Antibiotic Release.

Autor: Meiers J; Chemical Biology of Carbohydrates (CBCH), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, D-66123 Saarbrücken, Germany.; Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, Germany.; Department of Chemistry, Saarland University, D-66123 Saarbrücken, Germany., Rox K; Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, Germany.; Chemical Biology (CBIO), Helmholtz Centre for Infection Research (HZI), Helmholtz Centre for Infection Research, D-38124 Braunschweig, Germany., Titz A; Chemical Biology of Carbohydrates (CBCH), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, D-66123 Saarbrücken, Germany.; Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, Germany.; Department of Chemistry, Saarland University, D-66123 Saarbrücken, Germany.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Oct 27; Vol. 65 (20), pp. 13988-14014. Date of Electronic Publication: 2022 Oct 06.

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Directing Drugs to Bugs: Antibiotic-Carbohydrate Conjugates Targeting Biofilm-Associated Lectins of Pseudomonas aeruginosa .

Autor: Meiers J; Chemical Biology of Carbohydrates (CBCH), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, D-66123 Saarbrücken, Germany.; Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, D-38124 Braunschweig, Germany.; Department of Pharmacy and Department of Chemistry, Saarland University, D-66123 Saarbrücken, Germany., Zahorska E; Chemical Biology of Carbohydrates (CBCH), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, D-66123 Saarbrücken, Germany.; Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, D-38124 Braunschweig, Germany.; Department of Pharmacy and Department of Chemistry, Saarland University, D-66123 Saarbrücken, Germany., Röhrig T; Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, D-38124 Braunschweig, Germany.; Drug Design and Optimization (DDOP), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, D-66123 Saarbrücken, Germany., Hauck D; Chemical Biology of Carbohydrates (CBCH), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, D-66123 Saarbrücken, Germany.; Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, D-38124 Braunschweig, Germany., Wagner S; Chemical Biology of Carbohydrates (CBCH), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, D-66123 Saarbrücken, Germany.; Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, D-38124 Braunschweig, Germany., Titz A; Chemical Biology of Carbohydrates (CBCH), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, D-66123 Saarbrücken, Germany.; Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, D-38124 Braunschweig, Germany.; Department of Pharmacy and Department of Chemistry, Saarland University, D-66123 Saarbrücken, Germany.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Oct 22; Vol. 63 (20), pp. 11707-11724. Date of Electronic Publication: 2020 Oct 02.

Single-Molecule-Level Quantification Based on Atomic Force Microscopy Data Reveals the Interaction between Melittin and Lipopolysaccharide in Gram-Negative Bacteria.

Autor: Huang, Sheng^1,2 (AUTHOR) huangs@cqaa.cn, Su, Guoqi^1,2 (AUTHOR) 13021352791@163.com, Yang, Li² (AUTHOR), Yue, Liangguang² (AUTHOR), Chen, Li^1,2 (AUTHOR) chenliyouxiang8@163.com, Huang, Jinxiu^1,2 (AUTHOR) huangjx@cqaa.cn, Yang, Feiyun^1,2 (AUTHOR) huangjx@cqaa.cn

Publikováno v: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10508. 15p.