Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Meier-Schellersheim Martin"'
T cell receptor signaling must operate reliably under tight time constraints. While assuming quite different mechanisms, two prominent models of T cell receptor activation, kinetic segregation and kinetic proofreading, both introduce a distinct time
Externí odkaz:
http://arxiv.org/abs/2412.06773
Autor:
Zhang Fengkai, Smith Lucian P., Blinov Michael L., Faeder James, Hlavacek William S., Juan Tapia Jose, Keating Sarah M., Rodriguez Nicolas, Dräger Andreas, Harris Leonard A., Finney Andrew, Hu Bin, Hucka Michael, Meier-Schellersheim Martin
Publikováno v:
Journal of Integrative Bioinformatics, Vol 17, Iss 2-3 (2020)
Rule-based modeling is an approach that permits constructing reaction networks based on the specification of rules for molecular interactions and transformations. These rules can encompass details such as the interacting sub-molecular domains and the
Externí odkaz:
https://doaj.org/article/d421821be04f470bbb1e01bec3b7f69d
Biological cells can exchange messages through soluble molecules or membrane-bound receptors. In particular in the latter case, the interaction is usually located in specific regions of the interacting cells and may depend on or induce local morpholo
Externí odkaz:
http://arxiv.org/abs/2312.05703
Publikováno v:
Journal of Integrative Bioinformatics, Vol 15, Iss 1 (2018)
Rule-based modeling is an approach that permits constructing reaction networks based on the specification of rules for molecular interactions and transformations. These rules can encompass details such as the interacting sub-molecular domains (compon
Externí odkaz:
https://doaj.org/article/8fb3b816405943adbf48a7362dd471dc
Cells exhibit a wide variety of different shapes. This diversity poses a challenge for computational approaches that attempt to shed light on the role cell geometry plays in regulating cell physiology and behavior. The simulation platform Simmune is
Externí odkaz:
http://arxiv.org/abs/2003.13634
Autor:
Boughter, Christopher T.1 (AUTHOR) christopher.boughter@NIH.gov, Meier-Schellersheim, Martin1 (AUTHOR) christopher.boughter@NIH.gov
Publikováno v:
PLoS Computational Biology. 10/20/2023, Vol. 19 Issue 10, p1-26. 26p. 6 Graphs.
The path decomposition expansion represents the propagator of the irreversible reaction as a convolution of the first-passage, last-passage and rebinding time probability densities. Using path integral technique, we give an elementary, yet rigorous,
Externí odkaz:
http://arxiv.org/abs/1604.04903
Autor:
Yuan Kueh, Hao, Handel, Andreas, Hoffmann, Alexander, Chowell, Diego, Gottschalk, Rachel A., Singh, Harinder, Germain, Ronald N., Meier-Schellersheim, Martin, Miller-Jensen, Kathryn, Altan-Bonnet, Grégoire
Publikováno v:
Cell Systems; December 2024, Vol. 15 Issue: 12 p1148-1152, 5p
We present a simulation algorithm that accurately propagates a molecule pair using large time steps without the need to invoke the full exact analytical solutions of the Smoluchowski diffusion equation. Because the proposed method only uses uniform a
Externí odkaz:
http://arxiv.org/abs/1509.06810
Building on mathematical similarities between quantum mechanics and theories of diffusion-influenced reactions, we discuss how the propagator of a reacting molecule pair can be represented as a product of three factors in the Laplace domain. This rep
Externí odkaz:
http://arxiv.org/abs/1508.01595