Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Meidan Ying"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/a515e164bbbc46b79ed76c6cae30c2be
Autor:
Yuxiang Hu, Ziqi He, Shuangai Liu, Wenwen Ying, Yifan Chen, Manli Zhao, Min He, Xuan Wu, Yinbing Tang, Weizhong Gu, Meidan Ying, Jinhu Wang, Ting Tao
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110862- (2024)
Summary: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood and adolescence. The availability of appropriate and well-characterized preclinical models for RMS is limited, posing a challenge for investigating the molecular mech
Externí odkaz:
https://doaj.org/article/571bb153e6304b0cb9a29265bd36f474
Autor:
Shaowei Bing, Senfeng Xiang, Zhimei Xia, Yilong Wang, Zhonghai Guan, Jinxin Che, Aixiao Xu, Xiaowu Dong, Ji Cao, Bo Yang, Jinhu Wang, Qiaojun He, Meidan Ying
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 4, Pp 1522-1536 (2023)
While neuroblastoma accounts for 15% of childhood tumor-related deaths, treatments against neuroblastoma remain scarce and mainly consist of cytotoxic chemotherapeutic drugs. Currently, maintenance therapy of differentiation induction is the standard
Externí odkaz:
https://doaj.org/article/b2100f0774934776a8465eff9442a731
Autor:
Xuejing Shao, Yingqian Chen, Wei Wang, Wenxin Du, Xingya Zhang, Minyi Cai, Shaowei Bing, Ji Cao, Xiaojun Xu, Bo Yang, Qiaojun He, Meidan Ying
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 4, Pp 1856-1870 (2022)
In most acute promyelocytic leukemia (APL) cells, promyelocytic leukemia (PML) fuses to retinoic acid receptor α (RARα) due to chromosomal translocation, thus generating PML/RARα oncoprotein, which is a relatively stable oncoprotein for degradatio
Externí odkaz:
https://doaj.org/article/ae8dd000b16248dfac42fc61183a45c5
Autor:
Xiaomeng Gao, Jieqiong You, Yanling Gong, Meng Yuan, Haiying Zhu, Liang Fang, Hong Zhu, Meidan Ying, Qiaojun He, Bo Yang, Ji Cao
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 3, Pp 1225-1239 (2022)
The dysregulation of transcription factors is widely associated with tumorigenesis. As the most well-defined transcription factor in multiple types of cancer, c-Myc can transform cells by transactivating various downstream genes. Given that there is
Externí odkaz:
https://doaj.org/article/9676cfef19674ac88ccbf278689f23d2
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 309-321 (2021)
Cullin-RING ligases (CRLs) recognize and interact with substrates for ubiquitination and degradation, and can be targeted for disease treatment when the abnormal expression of substrates involves pathologic processes. Phosphorylation, either of subst
Externí odkaz:
https://doaj.org/article/834b817a468e4627afd11d5983fb63b1
Autor:
Meng Yuan, Xiaobing Chen, Yitang Sun, Li Jiang, Zhongni Xia, Kaixiong Ye, Hong Jiang, Bo Yang, Meidan Ying, Ji Cao, Qiaojun He
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1426-1439 (2020)
The membrane protein claudin-3 (CLDN3) is critical for the formation and maintenance of tight junction and its high expression has been implicated in dictating malignant progression in various cancers. However, the post-translational modification of
Externí odkaz:
https://doaj.org/article/ca339e61354840a79421abd6901a67c9
Autor:
Ji Cao, Xiaobing Chen, Li Jiang, Bin Lu, Meng Yuan, Difeng Zhu, Hong Zhu, Qiaojun He, Bo Yang, Meidan Ying
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
DJ-1 protects cells from oxidative stress-induced cell death; however its role in ferroptosis is unclear. Here, the authors show that DJ-1 suppresses ferroptosis through the transsulfuration pathway to compensate for the depletion of intracellular cy
Externí odkaz:
https://doaj.org/article/cd84a2a1c9554ac791e7edd5b93d0ee2
Autor:
Tao Yuan, Zibo Chen, Fangjie Yan, Meijia Qian, Hong Luo, Song Ye, Ji Cao, Meidan Ying, Xiaoyang Dai, Renhua Gai, Bo Yang, Qiaojun He, Hong Zhu
Publikováno v:
Molecular Oncology, Vol 14, Iss 1, Pp 197-210 (2020)
Hepatocellular carcinoma (HCC) has emerged as one of the most prevalent life‐threatening cancers, and the high mortality rate is largely due to the metastasis. The sustained activation of Smad4 and transforming growth factor‐β (TGF‐β) is clos
Externí odkaz:
https://doaj.org/article/827e28fc63ba47519fc60a8543d9f7ac
Autor:
Lu Chen, Le Chen, Zhiyuan Qin, Jinxiu Lei, Sheng Ye, Kui Zeng, Hua Wang, Meidan Ying, Jianqing Gao, Su Zeng, Lushan Yu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 1008-1020 (2019)
Renal cell carcinoma (RCC) is one of the most common malignant tumors affecting the urogenital system, accounting for 90% of renal malignancies. Traditional chemotherapy options are often the front-line choice of regimen in the treatment of patients
Externí odkaz:
https://doaj.org/article/fc12bb3436c04f4a9b3c659371c83270