Unc13A dynamically stabilizes vesicle priming at synaptic release sites for short-term facilitation and homeostatic potentiation

Autor: Meida Jusyte, Natalie Blaum, Mathias A. Böhme, Manon M.M. Berns, Alix E. Bonard, Ábel B. Vámosi, Kavya V. Pushpalatha, Janus R.L. Kobbersmed, Alexander M. Walter

Publikováno v: Cell Reports, Vol 42, Iss 6, Pp 112541- (2023)

Summary: Presynaptic plasticity adjusts neurotransmitter (NT) liberation. Short-term facilitation (STF) tunes synapses to millisecond repetitive activation, while presynaptic homeostatic potentiation (PHP) of NT release stabilizes transmission over m

Externí odkaz: https://doaj.org/article/172d957f20e44bc4b773e41acf08f85f

Rapid active zone remodeling consolidates presynaptic potentiation

Autor: Mathias A. Böhme, Anthony W. McCarthy, Andreas T. Grasskamp, Christine B. Beuschel, Pragya Goel, Meida Jusyte, Desiree Laber, Sheng Huang, Ulises Rey, Astrid G. Petzoldt, Martin Lehmann, Fabian Göttfert, Pejmun Haghighi, Stefan W. Hell, David Owald, Dion Dickman, Stephan J. Sigrist, Alexander M. Walter

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

Synaptic plasticity ensures functionality during perturbations and enables memory formation. Here, the authors describe homeostatic functional and nano-modular active zone modifications for immediate and long-lasting enhancement of neurotransmitter r

Externí odkaz: https://doaj.org/article/9733b2fe50774e4e995b69653b092187

Learning and Its Neural Correlates in a Virtual Environment for Honeybees

Autor: Hanna Zwaka, Ruth Bartels, Sophie Lehfeldt, Meida Jusyte, Sören Hantke, Simon Menzel, Jacob Gora, Rafael Alberdi, Randolf Menzel

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 12 (2019)

The search for neural correlates of operant and observational learning requires a combination of two (experimental) conditions that are very difficult to combine: stable recording from high order neurons and free movement of the animal in a rather na

Externí odkaz: https://doaj.org/article/3e0d326bc2ee4a2e8ef746516d4bb95a

Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials

Autor: Andreas T. Grasskamp, Meida Jusyte, Anthony W. McCarthy, Torsten W.B. Götz, Susanne Ditlevsen, Alexander M. Walter

Publikováno v: Grasskamp, A T, Jusyte, M, McCarthy, A W, Götz, T W B, Ditlevsen, S & Walter, A M 2023, ' Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials ', Frontiers in Cellular Neuroscience, vol. 17, 1129417 . https://doi.org/10.3389/fncel.2023.1129417

Synaptic transmission relies on presynaptic neurotransmitter (NT) release from synaptic vesicles (SVs) and on NT detection by postsynaptic receptors. Transmission exists in two principal modes: action-potential (AP) evoked and AP-independent, “spon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1054f2c84fda9009a439f363c9765011
https://doi.org/10.1101/2020.08.28.271742

Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca

Autor: Janus Rl, Kobbersmed, Andreas T, Grasskamp, Meida, Jusyte, Mathias A, Böhme, Susanne, Ditlevsen, Jakob Balslev, Sørensen, Alexander M, Walter

Publikováno v: eLife

Chemical synaptic transmission relies on the Ca2+-induced fusion of transmitter-laden vesicles whose coupling distance to Ca2+ channels determines synaptic release probability and short-term plasticity, the facilitation or depression of repetitive re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::748a912f4b1ea02f38ead6c3b4025aef
https://pubmed.ncbi.nlm.nih.gov/32077852