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pro vyhledávání: '"Meibo Chen"'
Autor:
Michael Jeremy Shapiro, Joshua Anderson, Michael Jonathan Lehrke, Meibo Chen, Molly Nelson Holte, Virginia Smith Shapiro
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
NKAP is a multi-functional nuclear protein that has been shown to be essential for hematopoiesis. Deletion of NKAP in hematopoietic stem cells (HSCs) was previously found to result in rapid lethality and hematopoietic failure. NKAP deficient cells al
Externí odkaz:
https://doaj.org/article/7de0739ec1434095b7b29839cef768b1
Autor:
Virginia Smith Shapiro, Meibo Chen, Michael J. Shapiro, Molly Nelson Holte, Joshua Anderson, Michael Jonathan Lehrke
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
NKAP is a multi-functional nuclear protein that has been shown to be essential for hematopoiesis. Deletion of NKAP in hematopoietic stem cells (HSCs) was previously found to result in rapid lethality and hematopoietic failure. NKAP deficient cells al
Autor:
Rachael Philips, Meibo Chen, Doug McWilliams, Paul Belmonte, Megan Constans, Scott Hiebert, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 194:51.6-51.6
In order to generate functional peripheral T cells, proper gene regulation during T cell development is critical. Development involves both the activation and repression of genes as cells progress through each developmental checkpoint. Histone acetyl
Autor:
Barsha Dash, Fan-Chi Hsu, Paul Belmonte, Megan Constans, Meibo Chen, Douglas McWilliams, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 194:51.16-51.16
T cell development depends on coordinated gene expression changes in order to progress through developmental checkpoints. The loss of transcription factor Runx1 in CD4-cre Runx1 conditional knockout (cKO) mice leads to decreased numbers of CD4 single
Autor:
Puspa Thapa, Meibo Chen, Doug McWilliams, Paul Belmonte, Megan Constans, Scott Hiebert, Derek Sant'Angelo, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 194:62.19-62.19
iNKT cells differentiate into functional subsets defined as NKT1, NKT2 and NKT17, characterized by their expression of transcription factors, T-bet, GATA3 and ROR-γt and production of IFN-γ, IL-4 and IL-17, respectively. In our earlier studies, we
Autor:
Fan-Chi Hsu, Paul Belmonte, Megan Constans, Meibo Chen, Doug McWilliams, Scott Hiebert, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 194:51.8-51.8
Recent thymic emigrants (RTEs) are newly generated T cells that need to undergo post-thymic maturation in the periphery. The mechanism of T cell maturation remains unclear. Histone deacetylase 3 (HDAC3) controls gene regulation, chromatin accessibili
Autor:
Puspa Thapa, Lauren Seaburg, Meibo Chen, Douglas McWilliams, Sarah Tangen, Scott Heibert, Derek Sant' Angelo, Virginia Shapiro
Publikováno v:
The Journal of Immunology. 192:51.3-51.3
Invariant Natural Killer T (iNKT) cells are an innate lineage of lymphocytes that can produce copious amount of cytokines within hours of stimulation. In the thymus, positive selection into the iNKT cell lineage occurs at the double positive (DP) sta
Publikováno v:
The Journal of Immunology. 190:52.36-52.36
Newly generated T cells must undergo phenotypic and functional maturation. Previously, we showed that the absence of NKAP severely curtailed T cell maturation, and NKAP-deficient recent thymic emigrants (RTEs) fail to enter the long-lived naïve per