Výsledky vyhledávání - "Mei-sheng Tai"

Avidity-Mediated Enhancement of In vivo Tumor Targeting by Single-Chain Fv Dimers

Autor: John E. McCartney, James S. Huston, Louis M. Weiner, Mei-Sheng Tai, L. L. Houston, Gregory P. Adams, James D. Marks, Walter F. Stafford

Publikováno v: Clinical Cancer Research. 12:1599-1605

Radiolabeled single-chain Fv (sFv) molecules display highly specific tumor retention in the severe combined immunodeficient (SCID) mouse model; however, the absolute quantity of sFv retained in the tumors is diminished by the rapid renal elimination

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e092d0e4bdc85653ba55ddb1d06ff8b
https://doi.org/10.1158/1078-0432.ccr-05-2217

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Optimization of in vivo tumor targeting in SCID mice with divalent forms of 741F8 anti-c-erbB-2 single-chain Fv: effects of dose escalation and repeated i.v. administration

Autor: Jamie Eisenberg, John E. McCartney, Michael A. Bookman, Gregory P. Adams, E J Wolf, Walter F. Stafford, Mei-Sheng Tai, L. L. Houston, Louis M. Weiner, James S. Huston

Publikováno v: Cancer Immunology, Immunotherapy. 40:299-306

Single-chain Fv molecules in monovalent (sFv) and divalent [(sFv')2] forms exhibit highly specific tumor targeting in mice as a result of their small size and rapid systemic clearance. As a consequence, there is a rapid reversal of the sFv blood/tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902c4531e34f46172e3f31b3a579bc7e
https://doi.org/10.1007/bf01519629

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Preclinical Studies and Optimization of Specific Tumor Delivery for 741F8 sFv, an Anti-c-erbB-2 Single-Chain Species

Autor: John E. McCartney, Axel A. Laminet, James S. Huston, Louis M. Werner, Mei-Sheng Tai, Gregory P. Adams, Sen Liu, Josephine Schultz, Jamie Eisenberg, E J Wolf, Gerald Apell, L. L. Houston, Hermann Oppermann, Walter F. Stafford, Bruce J. Giantonio, Michael A. Bookman

Publikováno v: International Journal of Pharmacognosy. 33:75-91

Single-chain Fv fragments (sFv) that bind tumor-associated antigens exhibit highly specific tumor targeting characteristics, based on studies of intravenous sFv administration to immunodeficient mice bearing human tumor xenografts. These features sug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f14c21278870505fbb9ed0cf1aa4fcca
https://doi.org/10.3109/13880209509067090

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Engineering disulfide-linked single-chain Fv dimers [(sFv')2] with improved solution and targeting properties: anti-digoxin 26–10 (sFv')2 and anti-c-erbB-2 741F8 (sFv')2 made by protein folding and bonded through C-terminal cysteinyl peptides

Autor: Sen Liu, Gregory P. Adams, Mei-Sheng Tai, Hermann Oppermann, Donald Jin, John E. McCartney, James S. Huston, Robert M. Hudziak, Axel A. Laminet, Irwin Fand, Michael A. Bookman, Louis M. Weiner, Walter F. Stafford, L. L. Houston

Publikováno v: "Protein Engineering, Design and Selection". 8:301-314

Single-chain Fv fusions with C-terminal cysteinyl peptides (sFv') have been engineered using model sFv proteins based upon the 26-10 anti-digoxin IgG and 741F8 anti-c-erbB-2 IgG monoclonal antibodies. As part of the 741F8 sFv construction process, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbcb2dd232369614f19186a6586b3647
https://doi.org/10.1093/protein/8.3.301

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Mammalian Cell Expression of Single–Chain Fv (sFv) Antibody Proteins and Their C–terminal Fusions with Interleukin–2 and Other Effector Domains

Autor: James S. Huston, Haimanti Dorai, Mei-Sheng Tai, Hermann Oppermann, Axel A. Laminet, John E. McCartney, L. L. Houston, Robert M. Hudziak

Publikováno v: Nature Biotechnology. 12:890-897

The production of several single-chain Fv (sFv) antibody proteins was examined by three modes of mammalian cell expression. Our primary model was the 741F8 anti-c-erbB-2 sFv, assembled as either the VH-VL or VL-VH, and expressed alone, with C-termina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a79aaa738d4826579e18bc3608925b
https://doi.org/10.1038/nbt0994-890

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Antigen recognition and targeted delivery by the single-chain Fv

Autor: John Mccartney, Hermann Oppermann, Mei-Sheng Tai, James S. Huston, Peter Keck

Publikováno v: Cell Biophysics. 22:189-224

The single-chain Fv (sFv) has proven attractive for immuno-targeting, both alone and as a targeting element within sFv fusion proteins. This chapter summarizes the features of sFv proteins that have sparked this interest, starting with the conservati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7528117f26b3472b7f9d5a2a06d8bd54
https://doi.org/10.1007/bf03033874

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Tumor targeting in a murine tumor xenograft model with the (sFv')2 divalent form of anti-c-erbB-2 single-chain Fv

Autor: James S. Huston, Gregory P. Adams, John E. McCartney, Mei-Sheng Tai, Robert M. Hudziak, Hermann Oppermann, Walter F. Stafford, Sen Liu, Irwin Fand, Gerald Apell, Axel Laminet, Michael A. Bookman, L. L. Houston, Louis M. Weiner

Publikováno v: Cell biophysics.

This investigation has utilized novel forms of the single-chain Fv (sFv), wherein a cysteine-containing peptide has been fused to the sFv carboxyl terminus to facilitate disulfide bonding or specific cross-linking of this sFv' to make divalent (sFv')

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1182b4aa79de85594efb6e2275abef45
https://pubmed.ncbi.nlm.nih.gov/7736532

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Medical applications of single-chain antibodies

Autor: Donald Jin, James S. Huston, Peter C. Keck, Hermann Oppermann, John Mccartney, Cristina Mottola-hartshorn, Mei-Sheng Tai, Frederick Warren

Publikováno v: International reviews of immunology. 10(2-3)

A single-chain antibody or single-chain Fv (sFv) incorporates the complete antibody binding site in a single polypeptide chain of minimal size, with an approximate molecular weight of 26,000. In antibodies, the antigen combining site is part of the F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7808fa2730c6b67b1a31b403bf77458e
https://pubmed.ncbi.nlm.nih.gov/8360586

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[3] Protein engineering of single-chain Fv analogs and fusion proteins

Autor: Meredith Mudgett-Hunter, Frederick Warren, Edgar Haber, Hermann Oppermann, James S. Huston, Mei-Sheng Tai, John Mccartney

Publikováno v: Methods in Enzymology ISBN: 9780121821043

Publisher Summary This chapter describes the minimal antibody binding site through the protein engineering of single-chain Fv analog and fusion proteins. In this approach, the genes encoding VH and VL domains of a given monoclonal antibody are connec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2315b9cef81fe78eb01eb97b141c576
https://doi.org/10.1016/0076-6879(91)03005-2

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Perturbation of ribosome subunit interaction by glutaraldehyde fixation

Autor: Michael C. Crossin, Gerson Kegeles, Mei-sheng Tai

Publikováno v: Biophysical Chemistry. 20:95-105

Ultracentrifugal analysis of ribosomal purity is complicated by the rapid reequilibration of ribosomes with their subunits, and this is further enhanced by the effects of hydrostatic pressure. Fixation of the ribosome system prior to ultracentrifugal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49780d6dd73ae4ebd55daacea5485176
https://doi.org/10.1016/0301-4622(84)80009-5

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