Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Mei-fang Jin"'
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Hypoxia-ischemia (HI) is the most common acute brain threat in neonates and a leading cause of neurodevelopmental impairment. Exploring the new molecular mechanism of HI brain injury has important clinical translational significance for the next clin
Externí odkaz:
https://doaj.org/article/1f8d9bc56df14c1ba7a0cc3dd16a24fa
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
IntroductionEpileptogenesis is understood as the plastic process that produces a persistent reorganization of the brain’s neural network after a precipitating injury (recurrent neonatal seizures, for instance) with a latent period, finally leading
Externí odkaz:
https://doaj.org/article/28c98704b9b248c9b16a9125f99ef8be
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Adipokines, including leptin, visfatin, adiponectin, and interleukin-6 (IL)-6, play multiple roles in the pathophysiology of epilepsy and febrile seizures (FS). We aimed to investigate the associations among plasma adipokines, mainly leptin, visfatin
Externí odkaz:
https://doaj.org/article/19f586d8023549ceaa409b013ebce3be
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
The ketogenic diet (KD) demonstrates antiepileptogenic and neuroprotective efficacy, but the precise mechanisms are unclear. Here we explored the mechanism through systematic proteomics analysis of the lithium chloride-pilocarpine rat model. Sprague-
Externí odkaz:
https://doaj.org/article/8de9b2fe081945bbad3bf6ecfcaeb62c
Autor:
Li-xiao Xu, Xiao-juan Tang, Yuan-yuan Yang, Mei Li, Mei-fang Jin, Po Miao, Xin Ding, Ying Wang, Yan-hong Li, Bin Sun, Xing Feng
Publikováno v:
Neural Regeneration Research, Vol 12, Iss 3, Pp 417-424 (2017)
Autophagy has been suggested to participate in the pathology of hypoxic-ischemic brain damage (HIBD). However, its regulatory role in HIBD remains unclear and was thus examined here using a rat model. To induce HIBD, the left common carotid artery wa
Externí odkaz:
https://doaj.org/article/609d9760bac24d038f51f7470d427547
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Recent evidence indicates that autophagy-mediated mitochondrial homeostasis is crucial for oxidative stress-related brain damage and repair. The highest concentration of melatonin is in the mitochondria of cells, and melatonin exhibits well-known ant
Externí odkaz:
https://doaj.org/article/adf223cfb1154851a75772e67d0429f5
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
The role of leptin in the pathogenesis of epilepsy is getting more and more attention in clinical and basic research. Although there are data indicating neuroprotective effects of elevated serum/brain leptin levels following acute seizures, no study
Externí odkaz:
https://doaj.org/article/ff73c72dc5e44610b652ee8d17071e40
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Developmental seizure-induced long-term neuronal hyperexcitation is partially mediated by regenerative mossy fiber sprouting in hippocampus. Yet, there are no effective drugs available to block this pathological process. Recently, leptin has been sho
Externí odkaz:
https://doaj.org/article/f0875740106d4257858eaa10bea7e57c
Autor:
Na-Na Wang, Zhi-Heng Li, He Zhao, Yan-Fang Tao, Li-Xiao Xu, Jun Lu, Lan Cao, Xiao-Juan Du, Li-Chao Sun, Wen-Li Zhao, Pei-Fang Xiao, Fang Fang, Guang-Hao Su, Yan-Hong Li, Gang Li, Yi-Ping Li, Yun-Yun Xu, Hui-Ting Zhou, Yi Wu, Mei-Fang Jin, Lin Liu, Jian Ni, Jian Wang, Shao-Yan Hu, Xue-Ming Zhu, Xing Feng, Jian Pan
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 1, Pp 1266-1292 (2015)
Polo-like kinase 1 (PLK1) is highly expressed in many cancers and therefore a biomarker of transformation and potential target for the development of cancer-specific small molecule drugs. RO3280 was recently identified as a novel PLK1 inhibitor; howe
Externí odkaz:
https://doaj.org/article/734192c36d9241a2821a94c5fc240ac6
Publikováno v:
Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 13, Iss 10, Pp 886-889 (2013)
Carotid atherosclerosis is closely related with ischemic stroke occurrence, development and recurrence. This study aims to make an evaluation of the effects of rosuvastatin on inflammatory factors, serum lipid and carotid atherosclerotic plaque in pa
Externí odkaz:
https://doaj.org/article/39f37b257558435a98b400300a612911