Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mei-Mann Hsueh"'
Autor:
Timothy W. Harper, Danshi Li, Huabin Sun, Mei-Mann Hsueh, Alexander Kover, Paul Levesque, Heather Finlay, James A. Johnson, John Lloyd, Ruth R. Wexler, Mary Lee Conder, Ningning Xu, Jeon Yoon T
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3018-3022
Phenethylaminoheterocycles have been prepared and assayed for inhibition of the Kv1.5 potassium ion channel as a potential approach to the treatment of atrial fibrillation. A diverse set of heterocycles were identified as potent Kv1.5 inhibitors and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72fef5b55ecd47e4b988296865f4c6b5
https://doi.org/10.1016/j.bmcl.2014.05.035
https://doi.org/10.1016/j.bmcl.2014.05.035
Autor:
Dezhi Xing, John Lloyd, Karnail S. Atwal, Mei Mann Hsueh, Yolanda Caringal, Ruth R. Wexler, Alexander Kover, Paul Levesque, Ji Jiang, Timothy W. Harper, Mary Lee Conder, Heather Finlay, Michael A. Blanar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1743-1747
Previously disclosed C6 amido and benzimidazole dihydropyrazolopyrimidines were potent and selective blockers of IKur current. Syntheses and SAR for C6 triazolo and imidazo dihydropyrazolopyrimidines series are described. Trifluoromethylcyclohexyl N(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e51799a21b73f50199fc9a444acca4
https://doi.org/10.1016/j.bmcl.2013.01.064
https://doi.org/10.1016/j.bmcl.2013.01.064
Autor:
Kan He, Stephen Johnson, Saeho Chong, Timothy W. Harper, Gang Luo, Baomin Xin, Mei-Mann Hsueh, Hong Cai, Joanna Zheng
Publikováno v:
Drug Metabolism and Disposition. 38:422-430
Evaluating biliary excretion, a major elimination pathway for many compounds, is important in drug discovery. The bile duct-cannulated (BDC) rat model is commonly used to determine the percentage of dose excreted as intact parent into bile. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43850231fd3652d3ba65b0020e0a457
https://doi.org/10.1124/dmd.108.026260
https://doi.org/10.1124/dmd.108.026260
Publikováno v:
Chemical research in toxicology. 18(5)
A sensitive and quantitative method was developed for the estimation of reactive metabolite formation in vitro. The method utilizes reduced glutathione (GSH) labeled with a fluorescence tag as a trapping agent and fluorescent detection for quantitati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88bb5d41cc88ea8821392706a749a368
https://pubmed.ncbi.nlm.nih.gov/15892584
https://pubmed.ncbi.nlm.nih.gov/15892584
Publikováno v:
HortScience. 25:1079c-1079
The effect of root mass on tomato fruit size in tissue culture was studied. The root mass of the ovaries was changed either by growing in culture media containing different concentrations of NAA (α– napthaleneacetic acid) or by culturing the ovari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f2e34cc854a5494686eaaa5083a766e
https://doi.org/10.21273/hortsci.25.9.1079c
https://doi.org/10.21273/hortsci.25.9.1079c
Publikováno v:
HortScience. 25:1079b-1079
Growing tomato fruits in tissue culture, using ovaries, could be used as a model system to study fruit development and sink strength/activity. Producing a “normal and healthy” fruit is essential in developing this system. Many factors affect the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9fe0d8653cfef0b2dfd89783c36c48f
https://doi.org/10.21273/hortsci.25.9.1079b
https://doi.org/10.21273/hortsci.25.9.1079b