Výsledky vyhledávání - "Mei-Ling Siu

Metabolism of 2-Methyl Analogs of 1α,25-Dihydroxyvitamin D3 in Rat Osteosarcoma Cells (UMR 106)

Autor: Hiroaki Takayama, Lynn Gennaro, Toshie Fujishima, Katsuhiro Konno, H Sekimoto, G.S. Reddy, Devara Sunita Rao, Mei-Ling Siu-Caldera, Paul Vouros

Publikováno v: Biological & Pharmaceutical Bulletin. 25:845-852

Several novel A-ring modified analogs of 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3] have been synthesized in order to investigate the structure-function relationships of 1alpha,25(OH)2D3. We synthesized A-ring modified analogs which contain a m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5999b1ce373f1c04982f2df565c4869
https://doi.org/10.1248/bpb.25.845

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1α,25-Dihydroxy-16-ene-23-yne-vitamin D3 and 1α,25-Dihydroxy-16-ene-23-yne-20-epi-vitaminD3: Analogs of 1α,25-Dihydroxyvitamin D3 That Resist Metabolism through the C-24 Oxidation Pathway Are Metabolized through the C-3 Epimerization Pathway

Autor: Norbert Astecker, D.Sunita Rao, Paul Vouros, Gino J. Sasso, Mei-Ling Siu-Caldera, Milan R. Uskokovic, Percy S. Manchand, A. Weiskopf, G. Satyanarayana Reddy

Publikováno v: Archives of Biochemistry and Biophysics. 383:197-205

The secosteroid hormone 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3] is metabolized in its target tissues through modifications of both the side chain and the A-ring. The C-24 oxidation pathway, the previously well established main side chain mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2bfdcedb4c00fee8f2da4814bc38c4b
https://doi.org/10.1006/abbi.2000.2074

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Isolation and identification of 1α-hydroxy-24-oxovitamin D 3 and 1α,23-dihydroxy-24-oxovitamin D 3

Autor: Mei-Ling Siu-Caldera, Kou-Yi Tserng, G. Satyanarayana Reddy, D.Sunita Rao, Seiichi Ishizuka, Edward A. Weinstein, Milan R. Uskokovic

Publikováno v: Biochemical Pharmacology. 58:1965-1973

1alpha,24(R)-Dihydroxyvitamin D3 [1alpha,24(R)(OH)2D3], a synthetic vitamin D3 analog, has been developed as a drug for topical use in the treatment of psoriasis. At present, the target tissue metabolism of 1alpha,24(R)(OH)2D3 is not understood compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9454c77a956227d216bc0ad6a756b3e
https://doi.org/10.1016/s0006-2952(99)00293-2

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Isolation and identification of 4,25-dihydroxyvitamin D2: a novel A-ring hydroxylated metabolite of vitamin D2

Autor: Kou-Yi Tserng, Mei-Ling Siu-Caldera, Milan R. Uskokovic, G. Satyanarayana Reddy, Ronald L. Horst, Ramesh Dayal, D.Sunita Rao

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 71:63-70

Vitamin D 2 is less toxic in rats when compared to vitamin D 3 . Our laboratory has been involved in research projects which were directed towards identifying the possible mechanisms responsible for the toxicity differences between vitamins D 2 and D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed5ed11808d960d18df771e07d4d818
https://doi.org/10.1016/s0960-0760(99)00125-9

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Physiological Significance of C-28 Hydroxylation in the Metabolism of 1α,25-Dihydroxyvitamin D2

Autor: G. Satyanarayana Reddy, D.Sunita Rao, Mei-Ling Siu-Caldera, Milan R. Uskokovic, Ronald L. Horst

Publikováno v: Archives of Biochemistry and Biophysics. 368:319-328

In our previous study, we indicated for the first time that C-28 hydroxylation plays a significant role in the metabolism of 1alpha, 25-dihydroxyvitamin D(2) [1alpha,25(OH)(2)D(2)] by identifying 1alpha,24(S),25,28-tetrahydroxyvitamin D(2) [1alpha,24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c66c3c8d4ef44311f82b917da09e2447
https://doi.org/10.1006/abbi.1999.1308

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Metabolism of 1α,25(OH)2D3 and its 20-epi analog integrates clonal expansion, maturation and apoptosis during HL-60 cell differentiation

Autor: Mark T. Drayson, Mei Ling Siu-Caldera, Reddy Gs, Lisa A. Wallington, Jennifer Durham, Moray J. Campbell, Geoffrey Brown

Publikováno v: Molecular and Cellular Endocrinology. 149:169-183

Induction of growth arrest and monocyte differentiation of HL-60 leukemia cells by 1alpha,25 dihydroxyvitamin D3 (1alpha,25(OH)2D3) is well established. By contrast, we have observed, that 1alpha,25(OH)2D3 and its metabolites play separate roles in c

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https://doi.org/10.1016/s0303-7207(98)00245-7

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1α,25-dihydroxy-24-oxo-16-ene vitamin D3, a metabolite of a synthetic vitamin D3 analog, 1α,25-dihydroxy-16-ene vitamin D3, is equipotent to its parent in modulating growth and differentiation of human leukemic cells

Autor: Anabela Santos-Moore, Mei-Ling Siu-Caldera, G. Satyanarayana Reddy, Yan Yun Liu, Sara Peleg, Milan R. Uskokovic, Surendra Sharma, Jeffrey Clark

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 59:405-412

1alpha,25(OH)2-16-ene-D3, a synthetic analog of the steroid hormone, 1alpha,25(OH)2D3, has great potential to become a drug in the treatment of leukemia and other proliferative disorders, because of its minimal in vivo calcemic activity associated wi

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https://doi.org/10.1016/s0960-0760(96)00134-3

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A Low-Calcemic Vitamin D Analog (Ro 25-4020) Inhibits the Growth of LNCaP Human Prostate Cancer Cells with Increased Potency by Producing an Active 24-Oxo Metabolite (Ro 29-9970)

Autor: Srilatha Swami, Mei-Ling Siu-Caldera, David Feldman, Satya G. Reddy, S F Sarabia, Milan R. Uskokovic, Xiao-Yan Zhao

Publikováno v: Recent Results in Cancer Research ISBN: 9783642624353

In this study, we have characterized a novel less-calcemic vitamin D analog Ro 25-4020 (1α, 25 dihydroxy-16-ene-5,6-trans-vitamin D3) and investigated the mechanisms underlying its enhanced growth inhibitory properties. We found that Ro 25-4020 (IC5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6401f2f6bed619e0828a9d044189ea31
https://doi.org/10.1007/978-3-642-55580-0_24

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Metabolism of 2-methyl analogs of 1alpha,25-dihydroxyvitamin D3 in rat osteosarcoma cells (UMR 106)

Autor: Devara, Sunita Rao, Mei-Ling, Siu-Caldera, Hiroko, Sekimoto, Lynn, Gennaro, Paul, Vouros, Hiroaki, Takayama, Katsuhiro, Konno, Toshie, Fujishima, Gudimetla Satyanarayana, Reddy

Publikováno v: Biologicalpharmaceutical bulletin. 25(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4fe8ee8e62ba7bdd04257dd48985e115
https://pubmed.ncbi.nlm.nih.gov/12132655

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Differential activities of 1alpha,25-dihydroxy-16-ene-vitamin D(3) analogs and their 3-epimers on human promyelocytic leukemia (HL-60) cell differentiation and apoptosis

Autor: Kimie Nakagawa, Yoshiko Sowa, Mayuko Kurobe, G. Satyanarayana Reddy, Toshio Okano, Mei-Ling Siu–Caldera, Keiichi Ozono, Milan R. Uskokovic

Publikováno v: Steroids. 66(3-5)

To clarify physiological role of the carbon 3 (C-3) epimerization of 1alpha,25(OH)(2)D(3) and biologic significance of a 3-epi metabolite of 1alpha,25(OH)(2)D(3), we examined biologic activities of the 3-epimers of 1alpha,25(OH)(2)D(3) and 1alpha,25(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3926ee89d5e24bacad17cd31ace7ce
https://pubmed.ncbi.nlm.nih.gov/11179741

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