Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Mei-Ling Le"'
Publikováno v:
Expert Opinion on Therapeutic Patents. 32:423-439
PDE1 has been demonstrated to be a potential drug target for a variety of diseases, such as Alzheimer's disease and cardiovascular disease. In the past decades, numerous PDE1 inhibitors with structural diversities have been developed and patented by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::775ebf65c3e8b3befd7b2322f412da5c
https://doi.org/10.1080/13543776.2022.2027910
https://doi.org/10.1080/13543776.2022.2027910
Autor:
Chen Zhang, Mei-Ling Le, Yi-Jing Tian, Mei-Yan Jiang, Hai-Bin Luo, Bei Zhang, Sirui Zhang, Meng-Xing Huang, Yinuo Wu
Publikováno v:
Journal of medicinal chemistry. 63(14)
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and devastating lung disease lacking effective therapy. To identify whether phosphodiesterase-1 (PDE1) inhibition could act as a novel target for the treatment of IPF, hit-to-lead structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e84e89dda7a315df1a6724f1897636a
https://pubmed.ncbi.nlm.nih.gov/32603117
https://pubmed.ncbi.nlm.nih.gov/32603117
Autor:
Hai-Bin Luo, Yinuo Wu, Chen Zhang, Mei-Yan Jiang, Qian Zhou, Pei Zhang, Bei Zhang, Mei-Ling Le
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(14)
Phosphodiesterase-9 (PDE9) is a promising target for the treatment of Alzheimer’s disease (AD). To discover efficient PDE9 inhibitors with good metabolic stability and solubility, a series of novel pyrazolopyrimidinone derivatives have been designe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8906ef05e90bdcbf97298b16e2fc90
https://pubmed.ncbi.nlm.nih.gov/32527553
https://pubmed.ncbi.nlm.nih.gov/32527553
Autor:
Yinuo Wu, Mei-Yan Jiang, Bei Zhang, Meng-Xing Huang, Hai-Bin Luo, Chen Zhang, Qian Zhou, Chuan Han, Mei-Ling Le
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 41:128016
The multi-target-directed-ligand (MTDL) strategy has been widely applied in the discovery of novel drugs for the treatment of Alzheimer’s disease (AD) because of the multifactorial pathological mechanisms of AD. Phosphodiesterase-2 (PDE2) has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cdb8a784e9049c0574b61f815bf2a8f
https://doi.org/10.1016/j.bmcl.2021.128016
https://doi.org/10.1016/j.bmcl.2021.128016
Autor:
Yinuo Wu, Yi-Jing Tian, Mei-Ling Le, Si-Rui Zhang, Chen Zhang, Meng-Xing Huang, Mei-Yan Jiang, Bei Zhang, Hai-Bin Luo
Publikováno v:
Journal of Medicinal Chemistry; 7/23/2020, Vol. 63 Issue 14, p7867-7879, 13p
Autor:
Mei-Ling Lee, 李美玲
101
Many experts have tried to promote students’ reading habit in elementary schools by proposing different reading researches. However, because of a lack of a systematic guide framework, teachers cannot effectively confirm the promoting effec
Many experts have tried to promote students’ reading habit in elementary schools by proposing different reading researches. However, because of a lack of a systematic guide framework, teachers cannot effectively confirm the promoting effec
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/n4r5zj
Autor:
Mei-Ling Lee, 李美玲
100
The second overall review of urban plan in Xinyi district, adjusting the functional position of the Xinyi district in Taipei City, emphasized in improving and unfolding the urban space’s "quality" and "feasibility". With an urban developme
The second overall review of urban plan in Xinyi district, adjusting the functional position of the Xinyi district in Taipei City, emphasized in improving and unfolding the urban space’s "quality" and "feasibility". With an urban developme
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/6hj3m4
Autor:
Mei-Ling Lee, 李美玲
100
Lao She was famed for the《Rickshaw Boy》, but Lao She said the《Divorce》 more than he like the《Rickshaw Boy》.《Divorce》under a book from character Of shaping, language of using, human seeking survival of all acts, and all mood,
Lao She was famed for the《Rickshaw Boy》, but Lao She said the《Divorce》 more than he like the《Rickshaw Boy》.《Divorce》under a book from character Of shaping, language of using, human seeking survival of all acts, and all mood,
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/97236781325363738976
Autor:
MEI-LING LEE, 李美玲
99
The government performance evaluation can not be evaluated by the relationship between governments』 expenditure and the outcomes of providing service for a long time. In this study、we try to form the relationship between the local governm
The government performance evaluation can not be evaluated by the relationship between governments』 expenditure and the outcomes of providing service for a long time. In this study、we try to form the relationship between the local governm
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/cg7drv
Autor:
Mei-Ling Lee, 李美玲
99
Facing the competitive environment of globalization, the application capacity of informationization, cyberization and digitization along the development of digital and information technology directly influence national competitiveness. Online
Facing the competitive environment of globalization, the application capacity of informationization, cyberization and digitization along the development of digital and information technology directly influence national competitiveness. Online
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/69896809869779340290