Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Mei-Lin Go"'
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Persistence of infection despite extensive chemotherapy with antibiotics displaying low MICs is a hallmark of lung disease caused by Mycobacterium abscessus (Mab). Thus, the classical MIC assay is a poor predictor of clinical outcome. Discovery of mo
Externí odkaz:
https://doaj.org/article/ec78e81d4a1e46769b82abb3867c231e
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT The dioxonaphthoimidazolium scaffold is a novel, highly bactericidal redox cycling antituberculosis chemotype that is reliant on the respiratory enzyme Type II NADH dehydrogenase (NDH2) for the generation of reactive oxygen species (ROS). He
Externí odkaz:
https://doaj.org/article/1e5c6baba743469489cb102c6f5f8064
Publikováno v:
Expert Opinion on Drug Discovery. 18:363-370
Autor:
Kevin Timothy Fridianto, Gregory Adrian Gunawan, Kiel Hards, Jickky Palmae Sarathy, Gregory M. Cook, Thomas Dick, Mei-Lin Go, Yulin Lam
Publikováno v:
RSC Medicinal Chemistry. 13:1605-1613
Herein, we establish the antimycobacterial activity of trialkylphosphonium-containing naphthoquinoneimidazoles, which exhibited limited redox activity but extensive membrane depolarization that resulted in depletion of ATP.
Autor:
Dereje Abate Negatu, Yulin Lam, Gregory M. Cook, Ming Li, Thomas Dick, Mei-Lin Go, Kevin T. Fridianto, Kiel Hards
Publikováno v:
Journal of Medicinal Chemistry. 64:15991-16007
Disruption of redox homeostasis in mycobacteria causes irreversible stress induction and cell death. Here, we report the dioxonaphthoimidazolium scaffold as a novel redox cycling antituberculosis chemotype with potent bactericidal activity against gr
Publikováno v:
Antibiotics, Vol 9, Iss 2, p 72 (2020)
Clarithromycin (CLR) is the corner stone in regimens for the treatment of lung disease caused by Mycobacterium abscessus (Mab). However, many strains harbor the CLR-inducible CLR resistance gene erm41, encoding a ribosome methylase. Induction of erm4
Externí odkaz:
https://doaj.org/article/dff4cfd3646e492786a8ea18e33b5547
Autor:
Jian Wei Teng, Mei Lin Go, Lloyd Wei Tat Tang, Hao Fan, Ravi Kumar Verma, Eric Chun Yong Chan, Lei Zhou, Siew Kwan Koh
Publikováno v:
Drug Metabolism and Disposition. 49:856-868
Infigratinib (INF) is a promising selective inhibitor of fibroblast growth factor receptors 1-3 that has recently been accorded both orphan drug designation and priority review status by the U.S Food and Drug Administration for the treatment of advan
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178168 (2017)
The dioxonapthoimidazolium YM155 is a survivin suppressant which has been investigated as an anticancer agent in clinical trials. Here, we investigated its growth inhibitory properties on a panel of immortalized and patient derived renal cell carcino
Externí odkaz:
https://doaj.org/article/a23f33d3bd1c43fcadfde7947ebc518c
Publikováno v:
Molecular Neurobiology
The SARS-CoV-2 virus that is the cause of coronavirus disease 2019 (COVID-19) affects not only peripheral organs such as the lungs and blood vessels, but also the central nervous system (CNS)—as seen by effects on smell, taste, seizures, stroke, ne
Autor:
Kevin Timothy Fridianto, Gregory Adrian Gunawan, Kiel Hards, Jickky Palmae Sarathy, Gregory M. Cook, Thomas Dick, Mei-Lin Go, Yulin Lam
Publikováno v:
SSRN Electronic Journal.