Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mei-Li Wen"'
Autor:
Ching Kim Tye, Chunhong Yan, Sarah C. Traeger, Wayne Vaccaro, Yingru Zhang, Gerry Everlof, Jianqing Li, Henry Yip, Peng Li, John T. Hunt, Michael A. Poss, Gregory D. Vite, Mussari Christopher P, Steven Sheriff, Asoka Ranasinghe, Haiying Zhang, Richard A. Westhouse, Dharmpal S. Dodd, Richard Rampulla, Zheng Yang, Frank Marsilio, Derek J. Norris, Wen-Ching Han, Tram N. Huynh, Yufen Zhao, Patrice Gill, Nirmala Raghavan, Lalgudi S. Harikrishnan, Ashvinikumar V. Gavai, Susan Wee, John S. Tokarski, Dauh-Rurng Wu, Arvind Mathur, Mei-Li Wen, Huiping Zhang, David R. Tortolani, George V. Delucca, Krista Menard, Francis Y. Lee, Claude A. Quesnelle, Dawn Sun, Vijay T. Ahuja, Daniel O'malley, Christine Huang, Muthoni G. Kamau
Publikováno v:
Journal of Medicinal Chemistry. 64:14247-14265
Inhibition of the bromodomain and extra-terminal (BET) family of adaptor proteins is an attractive strategy for targeting transcriptional regulation of key oncogenes, such as c-MYC. Starting with the screening hit 1, a combination of structure-activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6552024d7da4fe4ccaa968fbe1cf079
https://doi.org/10.1021/acs.jmedchem.1c00625
https://doi.org/10.1021/acs.jmedchem.1c00625
Publikováno v:
Applied Mechanics and Materials. 826:40-44
The purpose of this paper is to study the conceptual design and optimization of a compound coaxial helicopter. At the conceptual design phase, the compound coaxial helicopter design work was based on the conventional helicopter and fix-wing aircraft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c87f1a2b2fc8157e1bd0aed2527b83a3
https://doi.org/10.4028/www.scientific.net/amm.826.40
https://doi.org/10.4028/www.scientific.net/amm.826.40
Autor:
George L. Trainor, Jun Dai, Arvind Mathur, Francis Y. Lee, Sunilkumar Mandal, Yingru Zhang, Richard Rampulla, Kiran Babu Gona, Patrice Gill, Raja Thiruvenkadam, Victor R. Guarino, Wen-Ching Han, Ding Ren Shen, Aaron Balog, Mary Ellen Cvijic, Dauh-Rurng Wu, Gregory D. Vite, Krista Menard, Anne Rose, Sathiah Kandula, Ashvinikumar V. Gavai, Weifang Shan, John T. Hunt, Asoka Ranasinghe, Kelly McGlinchey, Richard A. Westhouse, Claude A. Quesnelle, Derek J. Norris, Mei-Li Wen, Ronald E. White, Kamalraj Thiyagarajan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1905-1909
This Letter describes synthesis, SAR, and biological activity of (2-oxo-1,4-benzodiazepin-3-yl)-succinamides as inhibitors of γ-secretase mediated signaling of Notch receptors. Optimization of this series led to the identification of BMS-871 (compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8122d9a6071f4288b3ad5fa62172ff7c
https://doi.org/10.1016/j.bmcl.2015.03.038
https://doi.org/10.1016/j.bmcl.2015.03.038
Autor:
Claude A. Quesnelle, Patrice Gill, Richard Rampulla, Ching Su, Gerry Everlof, George L. Trainor, Ke Chen, Vinod Arora, Richard A. Westhouse, Celia D’Arienzo, Andrew J. Tebben, Weifang Shan, John T. Hunt, Derek J. Norris, Louis J. Lombardo, Zheng Yang, Arvind Mathur, Mei-Li Wen, Yingru Zhang, Dauh-Rurng Wu, Wen-Ching Han, Krista Menard, Victor R. Guarino, Asoka Ranasinghe, Richard E. Olson, Ashvinikumar V. Gavai, Bruce S. Fischer, Phil S. Baran, Anne Rose, Lan Xiao, Ronald E. White, Mary Ellen Cvijic, Gregory D. Vite, Ding Ren Shen, Jere E. Meredith, Haiqing Wang, Francis Y. Lee, Aaron Balog
Publikováno v:
ACS Medicinal Chemistry Letters. 6:523-527
Structure-activity relationships in a series of (2-oxo-1,4-benzodiazepin-3-yl)-succinamides identified highly potent inhibitors of γ-secretase mediated signaling of Notch1/2/3/4 receptors. On the basis of its robust in vivo efficacy at tolerated dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3995231a45ba8104a424851cf0a94b
https://doi.org/10.1021/acsmedchemlett.5b00001
https://doi.org/10.1021/acsmedchemlett.5b00001
Autor:
Craig R. Fairchild, Francis Y. Lee, Anne Lewin, Kelly L. Covello, Rolf-Peter Ryseck, Mei-Li Wen, Donald R. Hawken, Robert A. Kramer, David Kan, Joseph Fargnoli, Stephen Castaneda
Publikováno v:
Clinical Cancer Research. 14:8123-8131
Purpose: Angiogenesis is a critical step in the establishment, growth, and metastasis of solid tumors, and combination of antiangiogenic agents with chemotherapy is an attractive therapeutic option. We investigated the potential of ixabepilone, the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfaa4a117b00a2f221ecd8bf889097b
https://doi.org/10.1158/1078-0432.ccr-08-0025
https://doi.org/10.1158/1078-0432.ccr-08-0025
Autor:
Dan You, Simone Oppenheimer, Brian E. Fink, Francis Y.F. Lee, Kristen A. Kellar, Bruce Rowley, Rolf P. Ryseck, Ching Ping Ho, David Bol, Chiang Yu, Mei-Li Wen, Matthew V. Lorenzi, Tai W. Wong, Gregory D. Vite
Publikováno v:
Molecular Cancer Therapeutics. 5:1571-1576
Receptor tyrosine kinases (RTK) remain an area of therapeutic interest because of their role in epithelial tumors, and experimental models specific to these targets are highly desirable. Chimeric receptors were prepared by in-frame fusion of the CD8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fb27ea3060c91c3d6561d069291438
https://doi.org/10.1158/1535-7163.mct-06-0078
https://doi.org/10.1158/1535-7163.mct-06-0078
Autor:
Cindy Wang, Joan M. Carboni, Marco M. Gottardis, Ann Greer, David Bol, Amy Camuso, Aixin Li, Bruce Rowley, Warren Hurlburt, Brent A. Rupnow, Francis Y.F. Lee, Darryl L. Hadsell, Mark D. Wittman, Saulnier Mark G, Upender Velaparthi, Tai W. Wong, Mei-Li Wen, Kurt Zimmermann, Richard A. Westhouse, Adrian V. Lee, Ching Ping Ho
Publikováno v:
Cancer Research. 65:3781-3787
The insulin-like growth factor I receptor (IGF-IR) is a transmembrane tyrosine kinase that is essential to growth and development and also thought to provide a survival signal for the maintenance of the transformed phenotype. There has been increasin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c86c8d67f12be593606f26753f4d4c
https://doi.org/10.1158/0008-5472.can-04-4602
https://doi.org/10.1158/0008-5472.can-04-4602
Autor:
John Wityak, Amrita Kamath, Louis J. Lombardo, Ping Chen, John T. Hunt, Ivan Inigo, Stephen Castaneda, Joel C. Barrish, Herbert E. Klei, Robert J. Schmidt, John S. Tokarski, Sidney Pitt, Derek J. Norris, Francis Y. Lee, Jagabandhu Das, Craig Fairchild, Kathy A. Johnston, Punit Marathe, Robert M. Borzilleri, Cornelius Lyndon A M, Suhong Pang, Mei-Li Wen, Russell Peterson, Gary L. Schieven, Kamelia Behnia, David Kan, Arthur M. Doweyko
Publikováno v:
Journal of Medicinal Chemistry. 47:6658-6661
A series of substituted 2-(aminopyridyl)- and 2-(aminopyrimidinyl)thiazole-5-carboxamides was identified as potent Src/Abl kinase inhibitors with excellent antiproliferative activity against hematological and solid tumor cell lines. Compound 13 was o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368da0e6e3d35ffae3cb0ff13f42526f
https://doi.org/10.1021/jm049486a
https://doi.org/10.1021/jm049486a
Autor:
Feng Roger Luo, Robert A. Wild, Anne Blackwood-Chirchir, Francis Y. Lee, Holly Palme, Yu Chen Barrett, Amy Camuso, Richard Smykla, Zheng Yang, Susan Galbraith, Krista Fager, Mei-Li Wen, Kelly McGlinchey
Publikováno v:
Cancer chemotherapy and pharmacology. 62(6)
Dasatinib (BMS-354825) is a potent, oral multi-targeted kinase inhibitor. It is an effective therapy for patients with imatinib-resistant or -intolerant Ph+ leukemias,. It has demonstrated promising preclinical anti-tumor activity, and is under clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79448555c9793d95601df5fba937a33d
https://pubmed.ncbi.nlm.nih.gov/18301894
https://pubmed.ncbi.nlm.nih.gov/18301894
Autor:
Patrice Gill, Daniel O'malley, Mary Ellen Cvijic, George L. Trainor, Gregory D. Vite, Yingru Zhang, Richard Rampulla, Richard A. Westhouse, Celia D’Arienzo, Derek J. Norris, Wen-Ching Han, Ching Su, Mei-Li Wen, Libing Chen, Arvind Mathur, Andrew J. Tebben, Brian E. Fink, Bruce S. Fischer, Robin Moore, Francis Y. Lee, David Rodrigues, Qian Ruan, Gerry Everlof, Weifang Shan, John T. Hunt, Claude A. Quesnelle, Soong-Hoon Kim, Krista Menard, Dauh-Rurng Wu, Asoka Ranasinghe, Zheng Yang, Yufen Zhao, Ashvinikumar V. Gavai, Aaron Balog, Haiqing Wang, Ching Kim Tye, Melissa Yarde
Publikováno v:
Cancer Research. 74:1643-1643
Deregulation of the Notch pathway has been shown to be oncogenic in numerous tissue types including T-cell acute lymphoblastic leukemia (T-ALL), breast cancer, non-small cell lung cancer, and colorectal carcinoma. Notch signal activation can cause un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::761271a037a354d0d93f3b39b4fca9c3
https://doi.org/10.1158/1538-7445.am2014-1643
https://doi.org/10.1158/1538-7445.am2014-1643